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W Gottwald

Publications and source records attributed to W Gottwald.

At least 19 recordsLinked to original sources
PubMed1999

[Not Available].

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Germany↗
PubMed1999

[Not Available].

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Germany↗
PubMed1998

[Expression of CD44 and isoforms v4, v5, v6, v7, v10--new prognostic parameters in ductal pancreatic carcinoma?].

UNLABELLED: Prognostically relevant factors based on the histological assessment of the resected pancreas are known. However, additional parameters, such as biological staging of the intrinsic malignant potentiality of the tumor, would be useful. There has been no uniform finding of a relationship between CD44 variant expression and tumor progression. METHOD: We assessed the expression pattern and prognostic impact of CD44 standard and CD44 isoforms v4, v5, v6, v7 and v10 in 40 ductal pancreatic carcinomas by immunochemistry on paraffin-embedded tumor material in patients after tumor resection. At the time of the investigation neither histomorphological parameters nor the survival time were known. RESULTS: There was no correlation between the histomorphological parameter and the expression of CD44 splice variants. CD44 splice variants v4-v10 were almost only expressed in tumor tissue. In ductal pancreatic carcinoma, patients with an overexpression of CD44 splice variants had a worse prognosis. However, because of the small number of cases this was statistically not significant. CONCLUSION: CD44 splice variants may have an influence on prognosis in ductal pancreatic carcinoma. However, further investigation on a larger number of patients is necessary to confirm these results.

Adenocarcinoma↗
PubMed1995

[Not Available].

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Germany↗
PubMed1990

[Not Available].

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Germany↗
PubMed1981

[Melkersson-Rosenthal syndrome. 2: Diagnosis, differential diagnosis, course, prognosis, neuropathology, therapy].

The diagnosis of Melkersson-Rosenthal syndrome (MRS) is rarely established, mainly because abortive cases are common. The principal symptoms are recurrent circumscribed swelling mostly of the orofacial region, peripheral facial paralysis and lingua plicata, which is nowadays no longer regarded as pathognostic. The syndrome is defined best as general disorder respectively "recurrent edematous granulomatosis" with specific pathoclisis to "angioneurotic intermittent edemas". The--non obligatory--classical histological finding is cheilitis granulomatosa. Etiopathogenesis, clinic, symptomatology and therapy are dealt with. Disorders of the function of the salivary glands, vegetative marginal symptoms, extrafacial intermittent edemas, cranial nerve syndromes and mostly mild peripheral neural and/or CNS syndromes along with psychiatric disorders are communicated. Atypical constellations of symptoms, differential diagnosis and neuropathological results are discussed. Finally neurovegetative, pathophysiological and phylogenetic aspects as well as therapeutic principles are mentioned.

Diagnosis, Differential↗