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Biomedical subjects

W H Annesley

Publications and source records attributed to W H Annesley.

47 records · Page 3Linked to original sources
PubMed1975

Nonfluorescent malignant melanoma of the choroid diagnosed with the radioactive phosphorus uptake test.

A 57-year-old white woman presented with a small malignant melanoma of the choroid in the macular area of the right eye. The lesion failed to produce a visual field defect or to show fluorescence with angiography, but the radioactive phosphorus uptake(P) test was positive. Histologically, the retinal pigment epithelium was intact over the tumor and the sensory retina was normal. This unusual finding was the most likely explanation for the normal visual field. The intact retinal pigment epithelium over this nonfluroescent melanoma suggests that the destruction of the retinal pigment epithelium occurring with most choroidal melanomas may partially explain why these tumors usually demonstrate fluorescence. This case emphasizes the great accuracy of the P test for diagnosing small malignant tumors of the choroid, even before other popular diagnostic modalities indicate the malignancy of the lesion.

Choroid↗
PubMed1975

Angioid streaks. I. Ophthalmoscopic variations and diagnostic problems.

Fifty-six patients with angioid streaks were evaluated ophthalmologically. Most had repeated fundus photography and fluorescein angiography during a follow-up period of 6 months to 7 years. The ophthalmoscopic variations and diagnostic difficulties which occurred were noted. In most instances, the angioid streaks were not initially recognized and the patient was referred with another diagnosis. In several cases, the peripapillary, macular, and peripheral changes seen with angioid streaks were found to simulate other better known fundus conditions, resulting in the erroneous diagnosis and improper treatment. In some cases, the angioid streaks were so subtle that they were overlooked and in others they were observed, but initially interpreted as something else. Because of the medical significance of angioid streaks, ophthalmologists should be aware of their variable features. These are discussed, with emphasis upon those subtleties which differentiate angioid streaks from other conditions which they may simulate. On the basis of these observations, an ophthalmoscopic differential diagnosis of angioid streaks is proposed.

Adolescent↗
PubMedDate not supplied

Lipofuscin pigment over benign and malignant choroidal tumors.

This study has shown that lipofuscin pigment may accumulate in RPE cells and macrophages over several types of benign and malignant choroidal tumors. The color of the pigment, however, varies with the nature and color of the underlying lesion. On the surface of deeply pigmented tumors the lipofuscin pigment may produce an orange color, whereas over amelanotic lesions it may appear brown or reddish-brown. On the surface of vascular tumors, such as choroidal hemangiomas, the lipofuscin is almost invisible ophthalmoscopically but may be demonstrated with fluorescein angiography. Although the presence of such pigment accumulation is suggestive of a malignant melanoma, it is not diagnostic and may occur over benign simulating lesions as well.

Choroid↗
PubMedDate not supplied

Fifteen year review of treated cases of retinal angiomatosis.

This study describes the experience of the Wills Eye Hospital Retina Service in the treatment of 125 eyes with retinal angiomatosis, with follow-up ranging from 1 to 15 years. The results of several treatment modalities are compared. In lesions smaller than 2.5 DD, xenon arc photocoagulation, argon laser photocoagulation, and cryotherapy all appear to be effective in eradicating the tumor and salvaging useful visual acuity. For lesions larger than 2.5 DD, cryotherapy appeared to offer the best results. The advantages and disadvantages of the various treatment modalities are discussed.

Adult↗