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Biomedical subjects

W H Binnie

Publications and source records attributed to W H Binnie.

At least 19 recordsLinked to original sources
PubMed1997

Amlexanox oral paste: a novel treatment that accelerates the healing of aphthous ulcers.

Five percent Amlexanox oral paste is a novel treatment for aphthous ulcers. In 3 controlled clinical studies that evaluated 1,124 immunocompetent patients with mild to moderate aphthous ulcers, 5% Amlexanox oral paste (Aphthasol) was shown to accelerate healing of these ulcers. Treatment with Aphthasol reduced the median time to ulcer healing and to complete pain resolution in a statistically significant manner. This was true both when treatment with 5% Amlexanox oral paste was compared to treatment with a vehicle and when treatment with the Amlexanox paste was compared to no treatment. Study results after 3 days comparing treatment with the paste and no treatment indicated complete healing of ulcers for 21% and 8% of patients, respectively. Complete resolution of pain after 3 days was reported for 44% and 20% of patients, respectively.

Administration, Topical↗
PubMed1996

Recurrent aphthous stomatitis.

Recurrent aphthous stomatitis (RAS) is the most common oral mucosal disease in North America. In some instances, RAS represents the central feature of the multisystem disease complex Behcet's syndrome. This article reviews the clinical features, contributing etiologic factors, and etiopathogenesis of RAS and Behcet's syndrome and describes therapeutic considerations and strategies essential to management of patients suffering from recurrent mouth ulcers.

Humans↗
PubMed1992

Mucous membrane pemphigoid. Treatment experience at two institutions.

The initial oral findings and treatment in 50 cases of mucous membrane pemphigoid are presented. Histologic and immunologic studies were undertaken in each case to confirm the clinical diagnosis. The treatments prescribed are summarized and illustrate that topical steroids are effective, but in some cases systemic steroid therapy with or without other immunologically active drugs is required. A significant number of patients had extraoral manifestations of the disorder.

Administration, Topical↗
PubMed1992

Oral presentation of pemphigus vulgaris and its response to systemic steroid therapy.

This article reviews our experience during a 20-year period with patients with oral lesions of pemphigus vulgaris. Of the 30 patients, 20 were women and 10 were men, with an age range of 24 to 68 years. The soft palate was involved in 80% of cases at initial presentation. Direct immunofluorescence studies were positive for IgG in the intercellular region in all cases where lesional tissue was histologically studied. Systemic steroid therapy alone controlled the disease in 24 patients, one patient was given no treatment, and the remaining five required additional treatment with either azathioprine, cyclophosphamide, or gold. Steroid therapy was continued in the long-term at a reduced dose, but side effects such as diabetes mellitus, hypertension, and duodenal ulcers were observed. Long-term steroid therapy is therefore the treatment of choice for the oral lesions of pemphigus vulgaris, but in some cases alternative treatment options may be required.

Adult↗
PubMed1992

Oral lesions in patients with psoriasis: a controlled study.

Stomatitis areata migrans was found in 5.4 percent of patients with psoriasis compared to 1 percent of control patients, while benign migratory glossitis was identified in 10.3 percent of patients with psoriasis and 2.5 percent of control patients. The association of these disorders with psoriasis indicates that they may be manifestations of psoriasis of the oral mucosa.

Female↗
PubMed1990

Sensitivity reaction to the cinnamonaldehyde component of toothpaste.

Sixteen patients developed a variety of oral lesions following a change in the toothpaste they used. Mucosal biopsy demonstrated features consistent with application of a topical medicament and patch testing, towards the constituents of the toothpastes, indicated the flavouring agent cinnamonaldehyde as being the likely responsible agent. Avoidance of the implicated toothpastes resulted in a considerable improvement in clinical signs and symptoms, whereas rechallenge in ten patients resulted in recurrence of symptoms in eight patients. It is concluded that sensitivity to the cinnamonaldehyde constituent of certain toothpastes, although uncommon, should be considered as a possible aetiological factor in patients presenting with non-specific oral changes.

Cinnamomum zeylanicum↗
PubMed1989

The effect of citrus limonoids on hamster buccal pouch carcinogenesis.

Two citrus limonoids, limonin and nomilin, were tested for their effects on the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced buccal pouch epidermoid carcinomas. Forty-five female Syrian hamsters were divided into three equal groups. The left buccal pouches of the animals in each group were pretreated topically with two applications of dimethylsulfoxide (DMSO) (group I), a 2.5% solution of limonin dissolved in DMSO (group II) or a 2.5% solution of nomilin dissolved in DMSO (group III). After this initial treatment, 11 hamsters from each group were selected. The left buccal pouches of these animals were painted 2 or 3 times weekly with a 0.5% solution of DMBA in mineral oil. On alternate days the pouches were painted with DMSO (I), the 2.5% solution of limonin (II) or the 2.5% solution of nomilin (III). The 12 remaining hamsters were used as controls and were painted with mineral oil and DMSO (I), mineral oil and the 2.5% solution of limonin (II), or mineral oil and the 2.5% solution of nomilin (III). After 15 weeks the hamsters were killed, the pouches were excised and the tumors were counted and measured. Tumors of variable size were common in the animals treated with DMBA. However, the animals receiving topical applications of limonin exhibited a 60% reduction in tumor burden. Further comparisons between groups I and II showed that this reduction in tumor burden was due to a 20% decrease in tumor number and a 50% decrease in tumor mass. The results for group III showed that nomilin was considerably less effective as an inhibitor of DMBA-induced neoplasia.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1984

Epidemiological and diagnostic aspects of oral squamous cell carcinoma.

Available data in United States on morbidity, mortality and survival is reviewed and trends discussed. Oral squamous cell carcinoma is a small problem in numerical terms, but is a highly lethal disease. The diagnosis is not difficult for the competent pathologist but problems arise in the diagnosis and prognosis of potentially malignant conditions. Our understanding of the behavior of dysplastic lesions is limited and any attempts to determine individuals "at risk" should be encouraged.

Carcinoma, Squamous Cell↗
PubMed1983

Etiology of oral squamous cell carcinoma.

The traditional list of etiological factors related to oral squamous cell carcinoma namely, tobacco, alcohol, syphilis, and oral sepsis has been expanded to include iron deficiency, chronic candidosis, and herpes simplex virus. The development of current concepts in these areas is discussed. In evaluating the need for future research, special emphasis is given to the concepts of multifactorial etiology and the role of mutagens. Suggestions for future research are discussed.

Alcoholic Beverages↗
PubMed1983

Recent advances in oral mucosal research.

Major progress in investigation of the normal structure and function of the oral mucosa has been made within the last ten years and has come principally from the application of various techniques developed in basic science disciplines to specific mucosal problems. However, it is apparent that many gaps still exist in our knowledge of the oral mucosa and, although it is to be expected that different workers will have distinct views on which of these are the most significant, some basic areas for further investigation can clearly be identified. For example, little is known about epithelial control systems and their disturbance by epithelial disease processes, about the nature of the interactions occurring during development and maintenance of the oral mucosal epithelia, or about the epithelial cell surface and its role in normal function. The specific properties and behavior of the cell populations of the subepithelial connective tissues appears to be poorly understood and the existence and significance of functional changes in mucosa with age and malnutrition are uncertain. It is increasingly apparent that successful progress in such investigations involves approaches using diverse methodologies. For example, epithelial-mesenchymal interactions are likely to involve multiple mesenchymal factors acting in concert to establish and maintain epithelial form and, because of this complexity, the nature of the inductive influences is not likely to be elucidated in model systems unless individual variables can be rigidly controlled. Defining the cellular and acellular elements in mesenchyme and reconstructing a functional mesenchyme from purified components may not be a simple task, but with current methods for cultivating mucosal keratinocytes and fibroblasts, as well as for purifying various components of the ground substance, it should be possible to initiate such a program of study. Some of the most dramatic advances made over the past 5-6 years in epidermal research have come about through the utilization of newly developed biochemical investigative techniques, examples of which include the use of gene cloning to study the organization of the keratin gene family, and the use of immuno-fluorescence with monoclonal antibodies to discern when various keratin proteins appear during differentiation.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1983

Intraoral melanoacanthoma.

Two cases of melanoacanthoma occurring on oral mucous membranes are presented. Melanoacanthoma is considered to be a benign mixed tumor of keratinoacytes admixed with pigment-laden dendritic melanocytes. All intraoral melanoacanthomas reported thus far have been pigmented lesions of the buccal mucosa and have occurred in young to middle-aged black females. These tumors may grow rapidly and therefore they often mimic the radial growth phase of an intraoral melanoma. Because melanocanthomas have no distinguishing clinical features, biopsy is mandatory.

Adult↗
PubMed1979

Applications of xeroradiography in dentistry-a review.

Xeroradiography is the technique in which electrostatically charged plates sensitive to X-rays are used in diagnostic radiology in place of conventional film. There has however been anxiety that radiation dosage for xeroradiography may be at unacceptably high levels. James et al., however, in 1973 showed that by increasing the kilovoltage to at least 120 the exposure could be reduced by 60 per cent. Using higher kV lateral oblique jaw and lateral and anteroposterior skull xeroradiographs have been produced with lower radiation exposure than conventional film. Bony detail is much more sharply delineated on xeroradiographs and soft tissues are visible on the same picture without use of a grid or wedge filter. These features are of obvious advantage in cephalometrics and orthognathic surgery. Panoramic techniques are potentially the most useful way of applying xeroradiography. The combination of full jaw coverage with the sharp definition only possible at present with intra-oral radiographs would provide more information for the dentist, save time for the radiographer and reduce the dose to the patient. Excellent results have been obtained with autopsy specimens on machines which develop 90kVp, but optimal exposure for a normal adult requires a panoramic X-ray machine development 120 kVp. Xeroradiography has the advantage, therefore, of providing more detail of diagnostic value with lower radiation exposure to the patient. The process requires no silver, which is in increasingly short supply.

Humans↗
PubMed1977

The advantages of xeroradiography for panoramic examination of the jaws and teeth.

Xeroradiography is an electrostatic imaging method which was significant advantages over conventional radiographic techniques. This article introduces the use of xeroradiography for panoramic examination of the jaws. The resultant images not only contain superior local contrast and detail when compared to conventional panoramic radiographs but also correlate well with histopathologic changes. The investigation indicates that xeroradiography is an important new diagnostic tool for detection of disease of the jaws and teeth.

Adolescent↗