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W H Denner

Publications and source records attributed to W H Denner.

7 recordsLinked to original sources

Colourings and preservatives in food.

Colours and preservatives are only two of the many classes of additives in food but they are of interest because many reported cases of sensitivity involve these two groups of substances. Preservatives present the greatest potential health hazard being, by definition, biologically active. Colours and other additives are required to perform a technological function whilst remaining as biologically inert as possible. Food additives are controlled by the Food and Drugs Act 1955 on the basis of advice from the Food Advisory Committee (FAC). Lists of the permitted preservatives and colourings are available, together with details of restrictions on their uses; this information is continually being updated. Food labelling regulations mean that some information about additives can be determined from the labelling--but even if an additive is not listed on the package, one cannot always assume that it is not present in the product, since additives coming through in the original ingredients need not always be listed. Other exemptions also exist, so there can be no absolute certainty about the presence, or absence, of a specific additive. That information can only be obtained by contacting the manufacturer.

Food Coloring Agents↗

The metabolism of potassium dodecyl [35-S]sulphate in the rat.

The metabolic fate of potassium dodecyl [(35)S]sulphate was studied in rats. Intraperitoneal and oral administration of the ester into free-ranging animals were followed by the excretion of the bulk of the radioactivity in the urine within 12hr., approximately 17% being eliminated as inorganic [(35)S]sulphate. Similar results were obtained in experiments in which potassium dodecyl [(35)S]sulphate was injected intravenously into anaesthetized rats with bile-duct and ureter cannulae. Analysis of urinary radioactivity revealed the presence of a new ester sulphate (metabolite A). This metabolite was isolated, purified and subsequently identified as the sulphate ester of 4-hydroxybutyric acid by paper, thin-layer and gas chromatography, by paper electrophoresis and by comparison of its properties with those of authentic butyric acid 4-sulphate. The identity of the metabolite was confirmed by isotope-dilution experiments. When either purified metabolite A or authentic potassium butyric acid 4[(35)S]-sulphate was administered to free-ranging rats the bulk of the radioactivity was eliminated unchanged in the urine within 12hr., approx. 20% of the dose appearing as inorganic [(35)S]sulphate. Whole-body radioautography and isolated-liver-perfusion experiments implicated the liver as the major site of metabolism of potassium dodecyl [(35)S]sulphate. It is suggested that butyric acid 4-sulphate probably arises by omega-oxidation of dodecyl sulphate to a fatty acid-like compound, which is then degraded by beta-oxidation.

Animals↗

Ammonia caramels: specifications and analysis.

Twenty three UK commercially produced ammonia caramels and eight experimentally produced ammonia caramels have been analysed by a range of physical and chemical tests, which include solids content, nitrogen levels, colour intensity and pH. A statistical treatment of the results is reported.

Ammonia↗