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W H Elliott

Publications and source records attributed to W H Elliott.

111 records · Page 7Linked to original sources

Bile acids, LXXIX. Synthesis and reduction of 1,4-dien-3-ones of various bile acids.

1,4-Dien-3-ones of various bile acids (IIa-d), their methyl esters (IIe-h), and their formylated derivatives (IIi-k) were synthesized and their reduction investigated by both catalytic and chemical methods as an alternative route to the synthesis of allo bile acids. Lithium-ammonia reduction proved to be the better method for the reduction of these 1,4-dien-3-ones producing the 3-keto- and 3 beta-hydroxy-allo bile acids (Vb-d) and (VIb-d) in 66-72% yields.

Ammonia↗