PubMed Health⌕ Search

Biomedical subjects

W H Hackeng

Publications and source records attributed to W H Hackeng.

13 recordsLinked to original sources
PubMed1978

[Acute rise in serum calcitonin concentration during haemodialysis (author's transl)].

Calcium and calcitonin concentrations were measured at the beginning, during and at the end of haemodialysis in 31 unselected patients on chronic intermittent haemodialysis. Blood samples were drawn at the end of dialysis under two different conditions: first, at the end of dialysis during which dialysate calcium concentration was always at 1.75 mmol/1 and secondly, at the end of dialysis with dialysate concentration elevated to 3.0 mmol/1 for the last third of the dialysis period. There was a highly significant increase in serum calcium concentration during haemodialysis, due to transmembranous calcium transfer in all instances. Calcitonin was detectable in free dialysis blood samples of 30 among the 31 patients. In 14 patients there was a significant increase in calcitonin concentration due to increasing calcium concentration during haemodialysis, while in 17 patients there was no change in the calcitonin concentration. Where calcitonin secretion could be stimulated there was a highly significant positive linear correlation, on a percentage basis, between calcium and calcitonin concentrations (r = 0.83, P less than 0.001).

Adult↗
PubMed1978

Ectopic secretion of calcitonin.

In 7 out of 25 unselected patients (28%) with a malignant disease, the circulating calcitonin level had increased. Pentagastrin i.v. gave no elevation of the calcitonin level comparable to the response in patients with medullary carcinoma of thyroid.

Aged↗
PubMed1977

[Parathyroid function in patients on chronic intermittent hemodialysis (author's transl)].

In three groups of hemodialysis patients the effects of an acute elevation of the serum calcium concentration on the predialysis parathyroid hormone concentration was studied. In the first group (13 patients) the predialysis parathyroid hormone (PTH) concentrations were normal, in the second group (11 patients) slightly elevated, in the third group (5 patients) highly elevated. Calcium was determined by atomic absorption-spectrophotometry, PTH by radioimmunological methods. In hemodialysis patients with normal predialysis PTH concentrations a correlation between the serum calcium concentration and the serum PTH concentration could not be detected. In hemodialysis patients with slightly as well as with highly elevated predialysis PTH concentrations a significant, linear, negative correlation was found between the calcium and the PTH concentration. This correlation, however, was only strong within groups of similar parathyroid hyperfunction. If instead of the absolute PTH concentration calcium is correlated with the changes of the PTH concentration in per cent, a strong correlation between these two parameters can be detected, it is independent of the degree of parathyroid hyperfunction.

Calcium↗
PubMed1976

Preoperative localization of enlarged parathyroid glands: indication for and criteria in the evaluation of venous sampling.

The results of 45 non-selective and 26 selective preoperative localization examinations in patients with primary hyperparathyroidism are compared with the findings at operation. First operations are distinguished from re-operations. On the basis of personal observations and data from the literature, indications for preoperative localization examination are established. Criteria are formulated for the evaluation of the result of preoperative localization examination as correct, erroneous or inconclusive.

Calcium↗
PubMed1975

Metabolic bone disease in the elderly. Biochemical studies in three different racial groups living in South Africa.

In an attempt to detect biochemical evidence of metabolic bone disease in the aged, we measured plasma parathyroid hormone (PTH) concentrations, in addition to plasma calcium, phosphorus, alkaline phosphatase and creatinine levels, in elderly White, Black and Indian women. All three ethnic groups demonstrated raised mean PTH concentrations. The Black patients, however, showed the greatest mean PTH elevation and the lowest plasma calcium level. Increased PTH secretion in elderly females may reflect either an age-related decline in renal function or subclinical osteomalacia. Elderly Black women seem particularly susceptible to the latter disorder, probably because of dietary and environmental factors.

Black or African American↗