Biomedical subjects

W H Jennings

Publications and source records attributed to W H Jennings.

12 recordsLinked to original sources

PubMed1986

Aplastic anemia due to tocainide.

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Aged↗

PubMed1983

Concomitant myelofibrosis with agnogenic myeloid metaplasia and malignant lymphoma.

The concomitant occurrence of non-Hodgkin's lymphoma and agnogenic myeloid metaplasia with myelofibrosis in one patient is described for the first time. Oral therapy with an alkylating agent resulted in partial remission.

Busulfan↗

PubMed1982

Alternate g-g- conformation for dinucleoside phosphates in solution.

An alternative g-g- conformation (conformer I') for dinucleosides in solution has been deduced, based on potential energy calculations and nuclear magnetic resonance spectroscopy. This conformation is characterized by larger glycosidic torsional angles (chi = 94-111 degrees) than those of conformer I (chi = 8-35 degrees), although the other torsional angles are similar. There are thus four stable conformers (I, I', II and III) for dinucleosides in equilibrium with the open forms. The structure of conformer I' supports that of the 'vertical' double helix constructed by Olson (W.K. Olson, Proc. Natl. Acad. Sci. U.S.A. 74, (1977) 1775). Our data may suggest the possibility of interconversion between the vertical double helix and the regular double helix of A-form DNA, RNA or A'-form RNA.

Dinucleoside Phosphates↗

PubMed1976