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Biomedical subjects

W H Lu

Publications and source records attributed to W H Lu.

At least 19 recordsLinked to original sources
PubMed2001

[Preliminary studies on process and ultramicro-pulverization on pharmacodynamics of Leech].

OBJECTIVE: To compare pharmacodynamics of decoction and powder of Leech; To identify effect of pharmacodynamics of Leech with new methods of process and ultrmicro-pulverization. METHOD: The size of ultramicor-powder of Leech and new method processed Leech is determined by BT-1500 size distributive instrument. It is compared that the pharmacodynamics of Leech decoction and powder as well as ultramicro-powder with new method processed of 1/2 decoction dose by anticoagulation and antithrombus action of mice. The safety of different samples is identified. RESULT: The pharmacodynamics of samples is as ultramicro-powder of Leech with new method processed > ultrmicro-powder of Leech > powder of Leech > decoction of Leech. CONCLUSION: The ultramicro-powder of Leech with new method processed has better pharmacodynamic effect and the smell of Leech is improved.

Animals↗
PubMed2001

[Detection of residual antibiotics in honey with capillary electrophoresis].

Five antibiotics compounds, tetracycline (TC), oxytetracycline (OTC), doxycycline (DOC), chlortetracycline (CTC) and chloramphenicol (CP), were successfully separated and determined by high performance capillary electrophoresis(HPCE). Effects of buffer pH, various organic additives and temperature on electrophoretic separation of antibiotics were investigated. Satisfactory separation of these five antibiotics was achieved in the buffer of pH 3.2, 0.02 mol/L Na2HPO4-0.01 mol/L citric acid with addition of 4% (V/V) N-methylmorpholine and 12% (V/V) acetonitrile within 20 minutes. The calibration graphs were linear by plotting the peak area against the sample concentration over the range of 150 micrograms/L to 750 micrograms/L and the correlation coefficients were greater than 0.9917. The detection limits were 10 micrograms/L for CP, 20 micrograms/L for TC, OTC and DOC and 40 micrograms/L for CP (signal to noise ratio > 5). HPCE method was successfully applied to the analysis of trace antibiotics in honey.

Doxycycline↗
PubMed2000

An evaluation of trauma team response in a major trauma hospital in 100 patients with predominantly minor injuries.

BACKGROUND: A prospective study of trauma team response and performance at a major trauma service was undertaken between June and September 1998. METHODS: Following activation of the trauma team, the timing of the trauma team's arrival, the subsequent early management of the patient, time to monitoring, X-ray investigation and procedures performed were documented. RESULTS: The study evaluated 100 activations, 76% male, mean age 32 years and 65% were due to road trauma. The team leader, airway doctor and surgical registrar were present on patient arrival in 96%, 90% and 76% of cases, respectively. The airway, procedure and scribe nurses were present on patient arrival in 77%, 97% and 95% of cases, respectively. The radiographer was present in 69% of cases. Comparison between normal and after-hour response revealed little difference in medical and radiographer response, but the after-hour nurse response was significantly worse (P < 0.001). The median time to achieve electrocardiogram monitoring, blood pressure reading, and oxygen saturation tracing was 3 (range: 1-13), 4 (range: 2-20) and 3 (range: 1-21) min, respectively. Intravenous cannulation, phlebotomy and dispatch of bloods occurred at median times of 5 (range: 2-22), 6 (range: 3-23) and 17 (range: 7-40) min. The median times for intubation, chest tube and splintage of fracture were 10 (range: 3-19), 10 (range: 6-14) and 26 (range: 19-55) min, respectively. CONCLUSIONS: The present study identified an excellent multidisciplinary trauma response and provides a template to improve performance in early trauma management.

Accidents, Traffic↗
PubMed1997

[The significance of sIL-2R detection in various hepatic diseases].

To study the alteration of the level of sIL-2R in acute and chronic hepatic diseases and its relation between alteration and the extent of damage to liver, the level of sIL-2R with hepatic disease was measured by a monoclonal and polyclonal Antibody ELISA. The result showed that the level increased differently in various hepatic diseases. The level of sIL-2R decreased when turning into severe hepatitis, acute hepatitis, active cirrhosis, chronic active hepatitis, hepatocarcinoma, compensative cirrhosis, chronic persistent hepatitis. It was suggested that the level of sIL-2R be considered of clinical value to estimate the extent of damage to liver in patients with progressive liver damage.

Adult↗
PubMed1993

[A preliminary experimental study on processing of peach kernel].

Contents of water, alcohol, ether soluble components and amygdalin of differently processed peach kernel (raw drug, scalded, stir-baked and steamed) were determined. The security of the decoctions from the four processed samples was compared. This paper provides a preliminary experimental basis for the rational utilization of peach kernel.

Amygdalin↗
PubMed1989

[Effects of huperzine A on electroencephalography power spectrum in rabbits].

Huperzine A (Hup-A) is a new alkaloid extracted from Huperzia serata in China. The effects of Hup-A on learning and memory are superior to those of physostigmine (Phys). The purpose of this paper is to observe the effects of Hup-A on EEG and EEG power spectrum in rabbits with micro-computer analysis. Hup-A 0.1 mg/kg iv in conscious rabbits produced, after 0.5 min, an alert EEG pattern, which showed decreases of lower frequency components and the total EEG power in cortical area, and the dominant frequency transferred from delta rhythm to theta rhythm in hippocampus. The same effects were seen with Phys 0.1 mg/kg. Scopolamine (Scop, 0.2 mg/kg iv) reversed significantly these effects of Hup-A (10 micrograms/rabbit, icv), but Scop butylbromide (0.4 mg/kg, iv) which can not pass the blood-brain barrier did not. Hup-A 0.2 mg/kg iv or Phys 0.3 mg/kg iv antagonized the EEG effects of Scop 0.3 mg/kg iv. The results indicate that the effects of Hup-A are closely related to the action on the central cholinergic system.

Alkaloids↗
PubMed1986

[Changes in protein in bile excretion from rat liver inoculated with BERH-2 hepatoma].

Rocket immunoelectrophoresis was used to assay the change in alpha fetoprotein (AFP) and albumin (Alb) in bile of rats 10 to 14 days after intrahepatic or intraperitoneal inoculation of BERH-2 hepatoma. The bile was collected from the common bile duct cannula. Total protein was determined by the Lowry method. The results showed that the excretion of total protein and Alb was reduced to 54% and 24% of the control in the intrahepatic group, and 65% and 56% of the control in the intraperitoneal group. Bile-AFP can be detected in rats in both groups and its concentration increased gradually during the tumor progression. In the hepatic group, the bile-AFP content per gram of tumor tissue was 29% of that in the intraperitoneal group. It suggests that decreased excretion of AFP, Alb and total protein in bile of rat bearing tumor in the liver be related to local obstruction of excretion by the tumor mass leading to constriction of biliary canaliculi.

Albumins↗
PubMed1982

The effect of accelerated release of rat neutrophil polymorphonuclear leucocytes from bone marrow on cell accumulation in inflammatory exudates.

The purpose of this study was to establish whether there was enhancement or impairment of the migratory abilities of polymorphonuclear leucocytes (PMN) released prematurely into the circulation during the inflammatory response, as a consequence of their shortened bone-marrow transit time. Sixteen healthy young adult male Sprague-Dawley rats received an i.v. injection of 1 microCi (methyl-3H) thymidine per g body wt, followed 40 h later by the i.p. injection of 2 ml of a mixture of Brain Heart Infusion/Proteose Peptone (BHI/PP). Four, 8 and 12 h after injection of BHI/PP, isotope incorporation in blood and peritoneal exudates was compared by liquid scintillation counting. During the first 12 h of the inflammatory response there was no significant difference between levels of isotope incorporation in blood and peritoneal exudates. Thus the accelerated release of cells from the bone marrow did not affect their ability to emigrate into the local lesions during this period.

Animals↗