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W H PRUSOFF

Publications and source records attributed to W H PRUSOFF.

At least 37 records · Page 2Linked to original sources
PubMed1961

Effect of reserpine on the 5-hydroxytryptamine and adenosinetriphosphate of the dog intestinal mucosa.

Homogenates were prepared of the mucous membrane of the small intestine from dogs previously treated with high doses of reserpine. The granular material sedimented from these homogenates was centrifuged over a density gradient. The dense fraction usually rich in adenosinetriphosphate and 5-hydroxytryptamine contained little amine and no nucleotide; on the other hand, the less dense material, believed to consist mainly of mitochondria, contained amounts of adenosinetriphosphate similar to those found in animals not treated with reserpine.

Adenine Nucleotides↗
PubMed1960

The distribution of 5-hydroxytryptamine and adenosinetriphosphate in cytoplasmic particles of the dog's small intestine.

The distribution of 5-hydroxytryptamine, adenosinetriphosphate, and succinic dehydrogenase in sucrose homogenates of the dog's small intestine has been studied. The adenosinetriphosphate was present in two different layers which could be separated by density gradient centrifugation. The upper layer contained also much succinic dehydrogenase, but no amine; it is probably composed of mitochondria. The lower layer contained not only adenosinetriphosphate but also the major portion of the particle-held 5-hydroxytryptamine. The mean molar ratio, amine: adenosinetriphosphate, in the lower layer was 2.6. The experiments suggest that adenosinetriphosphate in the intestine is of importance in the storage of 5-hydroxytryptamine, resembling the function of adenosinetriphosphate in the storage of the catechol amines of the adrenal medulla.

Adenine Nucleotides↗