Biomedical subjects
W H Replogle
Publications and source records attributed to W H Replogle.
Cancer prevention: national directions--local realities.
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Potential error in assessing accuracy of blood glucose monitoring systems.
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Onychomycosis: improved cure rates with itraconazole and terbinafine.
Onychomycosis is a disease that is important to our patients. Based on the current literature, recent developments of newer antifungal agents have improved cure rates of onychomycosis in the past few years (Table 3). No significant differences in safety and tolerability between itraconazole and terbinafine exist. Terbinafine does appear to have a preferable drug interaction profile. Daily therapy with either agent at standard doses has been shown to be effective when compared with placebo. When studies have directly compared daily administration of terbinafine and itraconazole, both medications have shown similar efficacy. Daily terbinafine therapy, however, appears to be more effective than pulse therapy with itraconazole. In addition, one small study showed a trend in favor of continuous rather than intermittent terbinafine therapy and similar efficacy of intermittent itraconazole and intermittent terbinafine therapy. Furthermore, terbinafine is more cost-effective than itraconazole. Finally, as quality-of-life data suggest, onychomycosis is important to our patients and affects both physical and psychosocial components of our patients' lives.
Evidence-based advertising?
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Chaperone use in primary care.
Two recently published surveys showed that a significant number of male adolescent medicine specialists performed unchaperoned pelvic examinations. Since this is a surprising finding, primary care physicians in Mississippi were surveyed to assess their use of chaperones during patient examinations. The survey found that male physicians typically did use chaperones for pelvic examinations. The frequency of chaperone use among male physicians when performing pelvic examinations did not vary by physician specialty. There was considerable variability in chaperone use by female physicians for both male and female patients.