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Biomedical subjects

W H Weidman

Publications and source records attributed to W H Weidman.

15 recordsLinked to original sources
PubMed1978

Cholesterol and triglycerides in serum lipoproteins of young persons in Rochester, Minnesota.

Cholesterol and triglyceride levels in whole sera and in the major lipoprotein fractions are presented for 2,421 children and youths in Rochester, Minnesota, ranging in age from 6 to 18 years. This cross-sectional study revealed subtle changes associated with puberty and the occurrence of certain additional sex-specific changes related to age. Hyperlipoproteinemia was detected in 101 youngsters; those cases exemplified types IIa (61 cases), IIb (5 cases), III (5 cases), and IV (30 cases). One case of type V hyperlipoproteinemia was observed in a second and comparable population sample of 1,245 young persons.

Adolescent↗
PubMed1977

Clinical course in adults with ventricular septal defect.

The 38 adult patients admitted to the Natural History Study with a small ventricular defect had a generally favorable course, similar to that noted in children and adolescents. None died under medical or surgical management, and none deteriorated. Among patients treated medically, complete closure was demonstrated during the course of follow-up in one, and in the others, wo were catheterized, the shunt remained the same or decreased slightly. Significant vascular disease did not develop in any of the patients. Among seven surgically-treated patients for whom data were complete, the defect was completely closed in six. In 18 patients who had large ventricular septal defects and mild or moderate pulmonary vascular disease, no significant change occurred in the four who were managed medically. Of 14 who underwent surgery, two died; six of eight who were recatheterized had normal pulmonary arterial pressure, with no residual shunt in four and a trivial shunt in two. Two patients who had had moderate vascular disease preoperatively (RP/RS was 0.4 in both) had open defects and slightly higher resistance ratios at final catheterization. Of the 18 patients with Eisenmenger's syndrome, eight died during the study, including one of two who underwent surgery. The other surgical patient survived and showed significant hemodynamic improvement at final catheterization.

Adult↗
PubMed1976

Comparison of serum cholesterol in children fed high, moderate, or low cholesterol milk diets during neonatal period.

The long-term effects of milk diets in infancy on the blood serum cholesterol concentrations were studied in 97 school children 7-12 yr of age. Detailed histories were available for these children with respect to their diets during infancy. The major criterion for inclusion in the study was milk (human milk, cow's milk, or commercial formula) as the exclusive source of diet cholesterol during the first 3 mo of life. Fasting blood cholesterol and triglycerides were measured in these 97 school children, and the current diets of 29 of the 97 were evaluated for daily cholesterol intake. A 7-day diet diary was recorded, the food intake was measured and analyzed for nutrients, and validity of the diets was verified by determination of urinary nitrogen excretion. Results of the study showed that the school children fed a low cholesterol formula during infancy had a mean serum cholesterol value 7-12 yr later that was lower than the mean values of the groups fed greater amounts of cholesterol in infancy. Analysis of current diets of 29 of the 97 school children showed that their current dietary intake of cholesterol was low. Dietary intake of cholesterol did not have a noticeable effect on the serum cholesterol levels of the 29 children.

Animals↗
PubMed1975

Etiology of right bundle-branch block pattern after surgical closure of ventricular-septal defects.

An incidence of 60 per cent of postoperative RBBB in the ECG's and available VCG's of 26 patients with isolated muscular VSD repaired was noted after ventriculotomy. In the 38 patients with VSD's near the membranous septum who underwent repair via the tricuspid valve, the incidence of postoperative RBBB was 44 per cent. Results suggested that either ventriculotomy or injury to the right bundle near the VSD can cause RBBB after surgical closure of the defect. Changes in the initial 0.02 second electrovectocardiographic forces in patients with postoperative RBBB were thought to result from central injury to the specialized conduction tissue supplying the interventricular septum. Peripheral RBBB, therefore, could be separated from central RBBB, by the appearance of the initial electrovectorcardiographic forces. For detection of these changes in initial forces, both the ECG recorded at 50 mm. per second and the Frank VCG were useful.

Adolescent↗
PubMed1975

Computer interpretation of Frank vectorcardiogram in normal infant: Longitudinal and cross-sectional observations from birth to 2 years of age.

The evolution of the Frank vectorcardiogram (VCG) was studied from longitudinal observations (60 normal infants) and from cross-sectional observations (231 normal infants) from birth to two years of age. Age specific normal values for the Cartesian coordinates of 14 vectors including maximal QRS-T and timed vectors in the horizontal and frontal plane were determined with both methods of analysis. In longitudinally followed infants the most significant involution of right ventricular forces occurred between the newborn period and 7-14 weeks of age. These changes included disappearance of clockwise horizontal loop rotation and a leftward shift of maximal and terminal forces as well as a rightward shift of initial vectors. Longitudinal observations were useful for prediction of the normal Frank VCG in the 7 to 14-week-old infant from values observed in the newborn period and for prediction of the horizontal loop rotation throughout infancy. Cross-sectional data showed a wider range of normal values than longitudinal data in the same 7 to 14-week-old infants, but age specific normal values were well reflected between 4 and 24 months of age from cross-sectional data.

Age Factors↗
PubMed1975

The association of scoliosis and congenital heart defects.

The effects of cardiac surgery on patients with congenital heart defects and the subsequent development of scoliosis were studied. A group of 998 patients with congenital heart defects who were less than sixteen years old were operated on at the Mayo Clinic during the ten-year period 1950 through 1959. Standing roentgenograms of the spine were made of 377 of the patients ten years or more after surgery. The ages of the patients at follow-up ranged from ten years and seven months to thirty-five years and three months, with a mean age of twenty-one years and four months. The average length of follow-up was fourteen years and eleven months. Of the 377 patients, thirty-two (8.5 per cent) had curves greater than 20 degrees. The female:male ratio of patients with congenital heart defects was 1:1, whereas of those who developed scoliosis it was 5:3. There was no correlation between scoliosis and the following: patient's sex, cardiac abnormality, size or side of the heart, side of the aortic arch, presence of cyanosis, age at surgery, number and type of surgical incisions, number and side of ribs removed, or number and type of surgical procedures.

Adolescent↗
PubMed1975

Inheritance of very low serum dopamine-beta-hydroxylase activity.

Serum dopamine-beta-hydroxylas (DBH) activity was measured in blood samples obtained from 841 children ages 6-12, 277 adults subjects, and 114 relatives of children with serum DBH activity of less than 50 units. Approximately 4% of the children and 3% of the adult subjects tested had very low sweum DBH activity (50 units or less). Because these subjects appeared to make up a separate subgroup within the population and because of a striking familial aggregation of subjects with very low enzyme activity, serum DBH activity was measured in blood obtained from members of 22 families of probands with very low serum enzyme activity. The results of sibship and pedigree analyses of the data were compatible with autosomal recessive inheritance of very low serum DBH activity. Unaffected parents of probands had serum DBH activity intermediate between that found in affected individuals and in control population. No significant correlation of serum DBH activity with either systolic or diastolic blood pressure was found in this randomly selected population of children.

Adult↗
PubMed1975

Hypoventilation secondary to chronic upper airway obstruction in childhood.

A 6-year-old child manifested symptoms and signs of alveolar hypoventilation and signs of cor pulmonale caused by obstruction of the upper airway. These symptoms and signs disappeared after tonsillectomy and adenoidectomy. The relationship of upper airway obstruction to hypoventilation and cor pulmonale is discussed in the hope of renewing interest in this problem and alerting physicians to think of this possiblity early in the evaluation of such patients.

Adenoidectomy↗