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Biomedical subjects

W Höbel

Publications and source records attributed to W Höbel.

17 recordsLinked to original sources
PubMed1991

Cimetidine suspension in patients with stage 0 gastro-oesophageal reflux disease.

One hundred and twenty-five patients with symptoms of heartburn and acid regurgitation but without endoscopic abnormalities were randomized to receive 200 mg cimetidine suspension four times daily or placebo for two weeks. Daily dairy cards were kept to evaluate the frequency and degree of symptoms. At two weeks cimetidine was significantly more effective than placebo. It is concluded that placebo suspension has a considerable effect on gastro-oesophageal reflux disease symptoms, but cimetidine suspension provides significantly better relief.

Adolescent↗
PubMed1987

[Treatment of uncomplicated duodenal ulcer using cimetidine alone and in combination with pirenzepine. A comparative study].

In a double-blind, randomised trial two drug regimens were compared in a group of 129 patients with uncomplicated duodenal ulcers, 64 receiving cimetidine (800 mg) and pirenzepine (50 mg) at bed-time, 65 receiving cimetidine (800 mg) and a placebo at bed-time. Neither statistically nor clinically was there an important difference in effectiveness and tolerance between the two drug regimens.

Adult↗
PubMed1986

Double-dummy comparison of suprofen and indometacin sustained release formulations.

In a randomized double-dummy study a new dosage form of alpha-methyl-4-(2-thienyl-carbonyl)phenylacetic acid (suprofen, Suprol), i.e., suprofen sustained release 600 mg tablets, was compared with indometacin sustained release 75 mg capsules. The test population included 60 hospitalized subjects in severe chronic pain requiring analgesic treatment. The treatment groups were homogeneous as to their anamnestic data. Treatment was given for 3 weeks; the drugs were uniformly administered in the morning and in the evening. The intensity of pain was assessed using a visual analog scale (VAS) prior to administration of the first dose on day 1 of the therapy, and then for up to 10 h. Further assessments of pain intensity and pain relief were obtained after 1, 2, and 3 weeks of therapy. Comparison of the mean pain intensity (VAS) at the individual rating times revealed statistically significant better pain relief with suprofen than with indometacin already 1 h after the administration (p less than 0.05, multivariate analysis of variance). This statistically significant difference as compared with indometacin was confirmed at all subsequent time points. The weekly assessments of pain intensity showed that the results obtained with suprofen were superior to those with indometacin, although they were not statistically significant. However, pain relief after 2 weeks' treatment with suprofen was significantly superior (p = 0.0061, exact test) to the result observed with indometacin. The results obtained with suprofen in weeks 1 and 3 were superior to those with indometacin, but they were not statistically significant.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1985

Effect of thymopentin on the mortality and immune response after an experimental herpes simplex infection in mice.

The effect of thymopentin on the mortality rate of mice treated with lethal doses (LD90) of herpes virus 2 and on the cytotoxic T cell activity after sublethal doses (LD10) of herpes virus was investigated in two series of experiments. Doses of 1, 0.1 or 0.01 ng of thymopentin per g/mouse were administered i.p. in each experiment, either 3 days before, 3 days (66 h) after, or 3 and 6 days after the herpes virus infection. The cumulative mortality rate was evaluated 10 days after the infection. Cytotoxic T cell activity was measured 3, 7 and 14 days after the infection. The 0.1-ng dose of thymopentin reduced the mortality rate to less than 50% (p = 0.0000) if it was administered 3 days before the infection. A single injection of any dose after infection did not reduce the mortality at all, while two injections of 0.1 ng reduced it by about 25% (p = 0.0038). A 1-ng dose showed a mild but significant reduction (p = 0.0313) if it was applied 3 days before the infection. The cytotoxic T cell activity was either not influenced or significantly modified (p less than 0.05), i.e. increased or decreased as compared to the control, depending on the dose and timing of thymopentin. A correlation between increased cytotoxic T cell activity and protection against mortality can be demonstrated, while no protection was observed in dose regimens where the cytotoxic T cell activity became reduced. The results are discussed in connection with earlier clinical studies in which the beneficial effect of thymopentin has been demonstrated in frequently relapsing herpes labialis and herpes genitalis patients.

Adjuvants, Immunologic↗
PubMed1985

Clinical effect of rectal application of suprofen in children. An open controlled study.

Antipyretic effect, tolerability, and acceptance of alpha-methyl-4-(2-thienylcarbonyl)-phenyl acetic acid (suprofen, Suprol) suppositories were tested in an open study including 90 hospitalized children with fever of various etiology. The mean rectal temperature prior to treatment was 39.3 degrees C. The dose regimen was chosen depending upon the body weight: Up to 4 suppositories were administered for maximally 4 days. Body temperature as well as pulse and respiratory rates were recorded prior to insertion of the suppository and 0.5, 1, 1.5, 2, 3, 4, 5 and 6 h following first application of the preparation. Regardless of sex and age the temperature was reduced in 85.5% of the cases; as compared to the initial values this reduction was after first application statistically significant at all rating times. The only adverse reaction - vomiting - was seen in 3 cases.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1983

Comparison of Papanicolaou staining and Feulgen staining for automated prescreening.

Feulgen staining is considered to be a quantitative DNA-specific cytochemical procedure. The applicability of this staining in high-resolution cytometry was tested in comparison with a regressive Papanicolaou staining. Papanicolaou-stained or Feulgen-stained intermediate and carcinoma cells selected by a cytologist were examined with a Zeiss scanning microscope photometer at 546 and 560 nm, respectively. After cell image segmentation and feature extraction, a statistical data evaluation was carried out by computer. Cell distributions with respect to four selected nuclear features demonstrated the influence of the staining procedure on cell feature measurements. The discriminatory power of the classification system as related to both staining procedures was studied using discriminant analysis. Using only nuclear features, a 7.3% improvement of the overall correct classification rate (from 85.0% to 92.3%) was achieved using Feulgen staining. The misclassification rate was simultaneously reduced by 50%. Using cytoplasmic as well as nuclear features, a 98% rate of correct classification was achieved.

Cell Nucleus↗
PubMed1977

Reappraisal of the clinical and etiologic significance of immunoglobulin deviations in autoimmune hemolytic anemia ('warm type').

56 patients with autoimmune hemolytic anemia ('warm type') (AIHA) were investigated for immunoglobulin deviations. Of these, 43 were repeatedly analyzed (mean 4 times). The mean observation time was 20 months. The immunoglobulin values were correlated with clinical (degree of hemolysis) and serological (immunoglobulin class of autoantibodies; strength of antiglobulin reaction) parameters and statistically evaluated by variance analysis. Although no significant deviations of immunoglobulins in AIHA were found as compared to a normal control group, the immunoglobulin disturbance most frequently seen was an elevation of IgM. This is interpreted as a possible lack or functional impairment of immunoregulatory T cells in AIHA.

Analysis of Variance↗
PubMed1976

[The lh-rh-test in men with fertility disorders (author's transl)].

89 mal patients with fertility disorders underwent a test with 50 mug synthetic LH-RH. The basal levels of FSH and LH are elevated in patients with azoospermia, with testicular atrophy, varicocele and Klinefelters syndrome. They increase with age. After stimulation with LH-RH the highest relative peaks (maximal value divided by control value) of LH are seen younger patients, in those with varicocele, and oligozoospermia. The FSH-values do not differ significantly between these groups. Low relative peaks of LH are seen in older patients. In Klinefelter's syndrome the relative peaks of FSH and LH are significantly lowered.

Adolescent↗
PubMed1976

Activation of intravascular coagulation by endotoxin: the significance of granulocytes and platelets.

The importance of granulocytes and/or platelets in endotoxin-induced generalized intravascular coagulation was studied as well as thrombocytopenic rabbits. Neutropenia and thrombocytopenia were induced by oral administration of busulphan. Generalized intravascular coagulation, as indicated by renal glomerular microclot formation, was initiated by two intravenous injections of endotoxin. Granulocyte counts before the second injection of endotoxin were most significantly related to activation of intravascular coagulation whereas platelet counts either before the first or second injection of endotoxin were not definitely related to the activation process. Renal glomerular microclots occurred in rabbits after two injections of endotoxin even when the platelet counts were between 500 and 5000/mul. These experiments indicated that granulocytes but not platelets are essential to the activation of endotoxin-induced intravascular coagulation.

Animals↗
PubMed1976

Oxygen consumption, heart rate, respiratory rate and rectal temperature in healthy newborns during the first two hours after birth.

A report is made on the continuous registration of oxygen consumption, heart rate, respiratory rate and rectal temperature in 32 neonates during the first two hours of life. A short account of the registration technique is given. A comparative study shows, that oxygen consumption, heart rate and respiratory rate fall during the period of observation, whereas the rectal temperature rises. 26 out of the 32 neonates demonstrated a approximately linear fall of each of the oxygen consumption values during the period of observation. There is a similar relationship, which is statistically verified, between the oxygen uptake and heart rate. Oxygen consumption and heart rate can be correlated with each other after the first 60 minutes of life. This close and direct relationship between the oxygen consumption and the heart rate, an important parameter of the heart and circulatory system, stresses clearly the importance of the continuous registration of oxygen consumption for monitoring the general condition of the neonate. A change from this situation means a risk for the neonate which must be clarified by blood-gas analysis. A continuous registration of oxygen uptake for the surveillance of the neonate includes numerous vital functions and appears to be a more suitable parameter than single parameters which include only partial functions. The application of the method is simple and safe for the infant.

Age Factors↗
PubMed1975

The effect of pindolol on exercise-induced cardiac acceleration in relation to plasma levels in man.

The correlation between the beta receptor blocking activity of pindolol and plasma level was studied in 8 subjects after a 10-mg oral dose. Exercise tachycardia was markedly reduced over a period of at least 6 hr. Significant effects were recorded 30 min after the drug. For each individual there was a close correlation between log plasma level and beta blockade. The regression lines were parallel as shown by analysis of covariance; the intercepts, however, were significantly different. It can be concluded that there is a correlation between plasma level and beta adrenergic blockade by pindolol, but the data failed to establish in different individuals the blood levels necessary to achieve effective adrenergic blockade.

Adult↗
PubMed1975

[Diagnostic errors and their reasons in tumors and preblastomatoses of the skin. Results of a statistical evaluation].

Clinical and histological findings and other available data of 6 521 skin excisates were compared with regard to differential diagnosis. It appears from our findings, that "naive" experience must be replaced by secured knowledge concerning frequencies of wrong diagnoses in definite situations, possible causes of errors, age-, sex-, and local distribution of different skin tumours. This knowledge may be a contribution to the improvement of clinical diagnoses.

Bowen's Disease↗