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Biomedical subjects

W Hölzel

Publications and source records attributed to W Hölzel.

At least 19 recordsLinked to original sources
PubMed1995

CYFRA 21-1--clinical applications and analytical requirements.

CYFRA 21-1 has proved to be a useful marker for non-small-cell lung cancer (NSCLC), which is the major form of lung cancer. Its most effective application is in monitoring. CYFRA 21-1 provides diagnostic information about the success of primary surgery, the response to chemotherapy and the detection of relapse. It is also an independent prognostic factor. The diagnostic potential may not be fully used because decision-making is currently based on group reference ranges. It seems useful to carry out systematic studies to investigate if the application can be improved and extended by using individual reference ranges for decision-making. In contrast to most of the other tumour markers the comparability of the commercial CYFRA 21-1- assays currently available on the market is good. The high degree of comparability should be maintained by international standardization. The analytical performance of the currently available commercial CYFRA 21-1 tests meets requirements derived from its current clinical applications. However, there are no data available about the analytical performance under field conditions. CYFRA 21-1, an established tumour marker for lung cancer, should be included in external quality assurance schemes.

Biomarkers, Tumor↗
PubMed1991

Analytical variation in immunoassays and its importance for medical decision making.

The analytical variation of immunoassays is at present significantly larger than that of other methods in clinical chemistry. The main sources of this large variation are variation between methods, lot to lot variation, and the large imprecision between-runs and within-runs when the methods are not performed on automated instruments. The variation can be substantially reduced by standardization, by ensuring the comparability between lots, and by automation of the analytical procedure. The extent to which the variation should be reduced is determined by the needs of medical decision making. It is demonstrated using the analytes TSH and CA 15-3 as examples that quality requirements have to be individually specified for each analyte. Such guidelines should be established by teams of international experts. They should include suggestions for reference methods, guidelines on the extent of comparability between routine methods, the maximum allowable deviations from lot to lot, and the minimum requirements for between-run precision. Such guidelines could form the basis for improvements which are directed towards the medical requirements.

Analysis of Variance↗
PubMed1985

[Principles of cooperation between the specialties of internal medicine, pathology and clinical biochemistry].

The optimal utilization of the knowledge and possibilities of pathological and clinical biochemistry presumes a close cooperation between it and the clinical specialties. The common working team of the GDR Society of Internal Medicine and the GDR Society for Clinical Chemistry and Laboratory Diagnostics makes theses of the central points of the cooperation in care, education, further education and postgraduate study and in research a subject for discussion. As essential tasks in the process of medical care are regarded the balance of the examination programme standing at the disposal, the establishment of diagnostic programmes, the establishment of organisational measures, the ascertainment of a use according to indication, the guarantee of the representance of examination material, the control of plausibility and the interpretation of test results. Since the realization of the tasks to a large extent depends on the cooperation of the specialities in education, further education and postgraduate study during the further education the clinician should become acquainted with the possibilities, the limits and the prerequisites for the performance of laboratory diagnostic investigations, the clinical biochemist with the problems of medical care and the value of the laboratory diagnosis in the total process of the treatment. In the field of research the result is a necessary cooperation in the clarification of patho-biochemical mechanisms, in the search for suitable laboratory diagnostic parameters for diagnostics and control of the course as well as in the statement of the validity of laboratory diagnostic parameters and parameter combinations taking into consideration the factors expenses, benefit and risk as well as further diagnostic possibilities.

Biochemistry↗
PubMed1975

[Information value of 2 color tests in the determination of alanine and aspartate-aminotransferases in liver and biliary tract diseases].

On the basis of examinations of altogether 197 patients the results of the changes of GOT and GPT were compared with the old and new colour tests of the AWD Dresden in normal histology, virus hepatitis, fatty liver, liver cirrhosis and posthepatic occlusion. Though the new colour test reveals a higher sensitivity, the differential diagnosis between selected liver diseases, especially virus hepatitis and posthepatic occlusion syndrome have become more difficult. The cause for this is the less significant separability between the individual regions of reference.

Alanine Transaminase↗
PubMed1975

[Old and new standardized color test for the determination of aspartate aminotransferase in the differential diagnosis of heart infarct and angina pectoris].

The usability of the new and old standardized colour test for the determination of the aspartate aminotransferase (GOT) (set of test instruments VEB Arzneimittelwerk Dresden) in the differential diagnosis between acute myocardial infarction and angina pectoris are compared. Concerning this problematics the new colour test does not evoke a better separation effect than the old one. Since with the change-over there were connected considerable uncertainties in the clinic it is recommended in case of a future standardisation to publish the regions of reference and first clinical experiences before the change-over.

Angina Pectoris↗