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Biomedical subjects

W Handrick

Publications and source records attributed to W Handrick.

At least 55 records · Page 3Linked to original sources
PubMed1988

[Principles of modern antibiotic therapy in the general practice and clinic. Discussion of the contribution by Walter Siegenthaler and Gertrude Siegenthaler-Zuber published in Z. gesamte inn. Med. 42 (1987) 614-618].

W. Siegenthaler's and G. Siegenthaler-Zuber's opinion, according to which in the majority of infections in practice an etiological (microbiological) diagnosis may be renounced and the guiding slogan "before therapy the gods have placed the diagnosis" should be relativized for the situation in the practice in contrast to the situation in the clinic, is opposed. Microbiological findings represent an unrenouncable basis for a rational antimicrobial chemotherapy in practice and clinic. In the individual case this does not exclude a calculated chemotherapy on account of a clinical and microbiological tentative diagnosis made by the physician in charge. But at the latest when the empiric therapy fails an efficient microbiologic diagnostics must be at our disposal.

Anti-Bacterial Agents↗
PubMed1988

[Staphylococcal endocarditis in the mitral valve prolapse syndrome].

A girl, aged 13 8/12 years, in whom has been known a syndrome of the mitral valve prolapse since the 10th year of age, fell ill with an acute endocarditis by staphylococcus aureus. As the therapy with antibiotics remained without any effects and due to an early embolic dispersion including the brain an operative approach was no more possible death occurred. The pathologic-anatomical investigations resulted in a distinct ulceropolypous endocarditis of the mitral valve. At the instance of this case report the most important facts nowadays known about the relation between the syndrome of mitral valve prolapse and endocarditis are summed up.

Adolescent↗
PubMed1988

Diagnostics of septicaemia in childhood by coagulation parameters.

The diagnostic importance of coagulation parameters was tested in 438 children with septicaemia by discriminant analysis. The values of 756 patients with other diseases had been analysed for comparison. After the selection of the parameters by multivariate analyses discriminant functions were calculated for different subgroups. The best discriminant functions were found for septic newborns up to the age of 3 days. Their use may be helpful for diagnostics in practice. A more weak discrimination power was evident in newborns beyond the 3rd day of life. A simultaneous comparison of 7 subgroups of newborns with different illnesses by 3 discriminant functions led to lower sensitivity rate and don't suit for practice. Beyond the postnatal period the diagnostic importance of coagulation parameters for septicemia is even lower. The low reparation capacity of thrombopoiesis in neonates may be a cause for the good discriminant functions for septicaemia. The reason for the better discrimination in the newborns up to the 3rd day could be the more profound defects in the coagulation system.

Blood Coagulation Tests↗
PubMed1988

[Listeriosis of the central nervous system in children beyond the neonatal period].

Observations on three children with neurolisteriosis (one case of meningitis, two cases of meningoencephalitis, each Serovar 4 b), show that even after the neonatal period, listeriosis must not be ignored in the process of diagnosis and therapy. It is the bacteriological examination of the cerebrospinal fluid, together with the blood culture, and not clinical symptoms and serology that guarantee a timely diagnosis and therapy (ampicillin and gentamicin).

Anti-Bacterial Agents↗
PubMed1988

[Neonatal infections caused by Haemophilus influenzae and Haemophilus parainfluenzae].

Haemophilus influenzae is a frequent causal agent of serious infections in infants. Mostly these infections occur at the age of 3 months to 3 years. Reports about infections in the neonatal period were rare in the past and most of them were single cases. In the last years an increase of neonatal infections due to Haemophilus influenzae had been reported. In the period from June 1980 to January 1986 we saw 5 newborns with severe infections due to Haemophilus influenzae and one neonate infected by Haemophilus parainfluenzae. By discussion of our cases and by review of the literature we want to show important aspects of pathogenesis, clinical symptoms, diagnostics and therapy of neonatal infections due to bacteria of the genus Haemophilus.

Haemophilus Infections↗
PubMed1988

[Haemophilus cellulitis--a contribution to the differential diagnosis of cheek swelling in childhood].

The Haemophilus influenzae cellulitis in infancy is a disease with special features in relation to early clinical recognition and treatment. We describe three such cases seen in our hospital with Haemophilus influenzae as etiological agent. One patient died in consequence of a purulent meningitis recognized not in time and developing under antibiotic therapy not suitable for H. i. cellulitis. After review of the most important data from the literature suggestions were made for adequate diagnostic and therapeutic procedures in patients with H. i. cellulitis.

Anti-Bacterial Agents↗