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Biomedical subjects

W Handrick

Publications and source records attributed to W Handrick.

At least 55 records · Page 3Linked to original sources
PubMed1991

[Some clinical aspects of therapeutic administration of iron preparations in childhood: iron and infections].

Iron is one of the most important metals for living organisms. There are many different reasons for an iron deficiency, which can lead to an iron deficiency anemia and can be treated by iron-containing drugs. But there are also some reasons leading to an iron overload, which can impair the defense against bacterial infections. An anemia in the course of an infection is usually not a result of iron deficiency but a physiological reaction against the invading microorganisms. A treatment with iron-containing drugs is only indicated in the case of an undoubtedly proven iron deficiency.

Anemia, Hypochromic↗
PubMed1991

[Urinary tract infection in childhood--an overview. 2. Therapy].

The prevention of pyelonephritic scarring is the main aim of the treatment of urinary tract infections (UTI) in children. Therefore, an early diagnosis and an immediate and effective antibiotic therapy of acute pyelonephritis is necessary, especially in the first years of life. Furthermore, recurrences of UTI should be prevented in children at high risk of developing renal scarring (vesicoureteric reflux, obstruction of the urinary tract, injured kidneys, bladder dysfunction). In the present paper recommendations are given for antibiotic therapy of acute UTI, antibacterial prophylaxis of reinfections and treatment of bladder dysfunctions.

Anti-Bacterial Agents↗
PubMed1991

[Liver abscess caused by Aeromonas hydrophila].

Because of the rare incidence of liver abscess in childhood and of extremely rare observed Aeromonas hydrophila as pathogen of such a disease we report on a 14 7/12 year old girl with a liver abscess. For the last 4 years she had to be enrolled in chronic hemodialysis. The treatment comprised opening of the abscess cavity and drainage, and antibiotic therapy with cefotiam. We were unable to isolate Aeromonas hydrophila in the environment of the hemodialysis center. Some aspects of clinical importance of liver abscess in childhood and of Aeromonas spp. as pathogens in human infections are discussed.

Adolescent↗
PubMed1991

[Bacteriologic diagnosis in suspicion of bacterial infection in newborn infants--a review].

The present paper gives a survey about bacteriological examinations, which had proved worthwhile in relation to own experiences and to the literature. Besides methods of preliminary diagnostics cultural examinations of samples from normally sterile body sites are in the center of discussion. The value of body surface cultures, however, especially swabs used for possible prediction of threatening infection is also discussed.

Bacteria↗
PubMed1990

Typing of multiple isolates of coagulase-negative staphylococci from blood cultures and cerebrospinal fluid in neonates and children: an approach to discriminate contaminants.

From eight neonates and children suspicious for suffering from septicemia and/or meningitis, coagulase negative staphylococci (CNS) were isolated from multiple blood cultures and from cerebrospinal fluids originating from different punctures. S. epidermidis was the predominant species. By a further typing using plasmid-profiles and exoprotein patterns besides the resistance phenotype, contaminants could be discriminated from the isolates as the probable etiologic agent exhibiting unique reaction patterns. CNS isolated from cases of septicemia together with other bacterial pathogens or from cases of presumed but not confirmed septicemia revealed as different.

Adolescent↗
PubMed1990

[Growth rate of glioblastoma multiforme].

The velocity of events in cases of glioblastomas is well known. In spite of modern methods of examination the perceivability can miss. By one's own experiences the value of the unchanged role of clinical and neurological examination is point out.

Brain Neoplasms↗
PubMed1990

[Recommendations for the diagnosis and therapy of meningitis, Waterhouse-Friderichsen syndrome and encephalitis in childhood].

Representatives of the working group of "Neuropaediatrics" and "Infectology" like to present recommendations on diagnostics and treatment of infectious diseases on the CNS. Individual opinions can not be considered in recommendations always. Therefore we have to understand these recommendations in this way that individual decisions will not be restricted in special situations.

Child↗
PubMed1990

[The differential diagnosis of hemarthrosis--septic arthritis in patients with hemophilia].

A 12-year-old boy with severe hemophilia A fell ill with high fever and painful swelling of joints. There was a delay of four days in the diagnosis of septic arthritis. The course of the disease shows some important distinguishing criteria, speaking in favour of septic arthritis: 1. longlasting temperature above 39 degree C; 2. an elevated peripheral leukocyte count; 3. increasing complaints despite normalisation of the coagulation defect.

Arthritis, Infectious↗
PubMed1990

[The significance of various hematological parameters for the early diagnosis of bacterial infection in premature and full-term neonates. 1. Patients and study methods, normal values for the blood picture of newborn infants].

We examined the white blood count in 101 premature infants and full-term neonates on their first day of life (before or within the 12th hour), on 2nd, 3rd, 4th, 5th, 10th, 15th and 20th day of life. Infection was suspected in the course in 31 infants (without demonstration of pathogenic organisms). In 73 infants without infections we were therefore able to establish normal values. We could establish reference limits corresponding to the standard deviation for all kinds of white blood cells, except the whole leucocyte count. Because of considerable individual differences of the whole white blood cell count in newborns without infections we fixed for this reference limits from 5 to 20 Gpt/l. The means of leucocyte and neutrophil counts reached their maximum in the 12th hour after birth, decreased until the 5th day of life and leveled off then. The segmented neutrophils and the lymphocyte counts crossed over after the 5th day of life resulting in a relative lymphocytosis. The physiologic left shift decreased in the first days of life. These described changes after birth were significant.

Bacterial Infections↗
PubMed1990

[The significance of various hematological parameters for the early diagnosis of bacterial infections in premature and full-term neonates. 2. The blood picture in premature and full-term neonates with suspicion of existing infection or with confirmed infection].

We compared the normal values of white blood counts in premature infants and full-term neonates, as described in part one of this paper, with blood counts of 31 infants with suspected infections and 81 infants with sepsis and/or meningitis. The half of these infected infants had leucocyte and neutrophil counts beyond the reference limits. The values tended to leucopenia in diseases beginning within the first five days of life and to leucocytosis later on. More than 80% of the patients had a left shift. One is able to predict a sepsis with a probability of 16.3%, according to our experiences, with leucocyte counts below 5 or above 20 Gpt/l. In the case of left shift the probability is about 25%. Combining these parameters the predictive value is even mounting to 56.1%. We were able to make a prognosis too referring to the blood count of infants with sepsis.

Bacterial Infections↗
PubMed1990

[The significance of various hematological parameters for the early diagnosis of bacterial infections in premature and full-term neonates. 3. Discussion of the study results].

Haematological examinations may contribute, especially by repeated investigations of parameters changing dynamically, to a greater safety of decisions concerning the beginning or termination of chemotherapy in neonates with suspected infections. We recommend to check the blood count every 6-12 h in such cases. A normal blood count does not exclude a sepsis but haematological changes may precede clinical symptoms for hours. We can confirm the good experiences of some authors with "screening-scores" to detect early infants with sepsis. Such a score should include I/T-Quotient, thrombocyte count, CRP and micro-ESR. This contributes to a greater predictive probability of an infection.

Bacterial Infections↗
PubMed1990

[Development and organization of breast milk collection centers in East Germany].

Human milk banking has a longstanding tradition in the GDR. We report on the main data of a survey carried out in 1987, actualized in 1989. Whereas human milk banking was widespread during the 1950s, it reached it's lowest level in 1972. In 1988 the amount of collected milk was nearly 200,000 litres (60 milk banks). Thus, the supply met the demand approximately. The development of the human milk banks is characterized by an increase of the number of milk banks (mostly the banks are affiliated to a children's hospital) and the collecting capacity. Half of the milk banks carries out the collection on a daily basis. This makes it possible to provide fresh milk with it's clear-cut advantages, especially in immunological respect. Otherwise the milk is stored after boiling, freezing or pasteurization. The feeding of very low birth weight newborns with fresh human milk is steadily increasing with corresponding consequences for the quality control of donated milk and the management of milk banks.

Germany, East↗
PubMed1990

[Bacterial heart diseases in childhood. An overview of diseases 1971-1987].

The authors give a review of patients with bacterial cardiac disease treated in the Paediatric Clinic of Karl-Marx-University Leipzig between 1971 and 1987. During this period 32 patients were observed, which amounts to about 2 to 3 patients per year. The majority of patients had congenital heart disease. Despite antibiotic therapy the prognosis of this infection is still serious: One third of the patients died, and diagnosis is made with considerable delay in some cases. Problems and diagnostic and therapeutic approaches are discussed.

Bacteria↗
PubMed1989

[Infections caused by Candida krusei in newborn infants].

Experiences are described about systemic infections with fungaemia due to Candida krusei in seven newborns treated in a department of neonatology because of several perinatal problems. The origin of this outbreak cold not be established. In six patients the infection was early detected and successfully treated with miconazole and/or ketoconazole, all six newborns recovered. Infections due to Candida krusei are extremely rare in humans. This report demonstrates the clinical picture of this infection in newborns.

Antifungal Agents↗
PubMed1989

[Pneumococcal infections in children: hemolytic-uremic syndrome].

By the example of a case-report diagnostic and therapeutic features of the haemolytic-uraemic syndrome are discussed within the frame of infections by pneumococci. In case of infections by pneumococci but also of those ones caused by other bacteria or viruses neuraminidase may be set free, that on its part may lead to an enzyme-induced haemolysis and in some cases also to a damage of other cell systems. In case of an active share of the kidney a haemolytic-uraemic syndrome may be the consequence.

Hemolytic-Uremic Syndrome↗
PubMed1989

[Clinically relevant pathogens isolated from blood cultures of inpatient treated children (1972 to 1985)].

Blood cultures are extremely useful in diagnosing various bacteremic diseases in childhood. The results obtained in this study are presented in relation to two periods of equal length (1972-1978, 1979-1985). At the present time there are about 22 relevant isolates from blood cultures per 1000 admitted children and year in the Department of Pediatrics, and about 3 isolates per 1000 admitted children and year in the Department of Pediatric Surgery, respectively. From newborns we isolated most frequently E. coli, Staph. aureus, B-Streptococci, Pseudomonas aeruginosa, Klebsiella pneumoniae, and yeasts. From children beyond the first month of life Haemophilus influenzae, Streptococcus pneumoniae, other streptococci, Neisseria meningitidis, and Staph. aureus were the most frequent identified etiologic agents. The main factors influencing the spectrum of agents causing bacteremia are: age of patients, status of hospitals, and applicated diagnostic and therapeutic procedures.

Bacteria↗