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Biomedical subjects

W Handrick

Publications and source records attributed to W Handrick.

At least 109 records · Page 6Linked to original sources
PubMed1987

[Sodium homeostasis in neonatal infection of eutrophic premature infants].

In 14 premature infants suffering from bacterial sepsis during the first week of life the daily renal sodium and potassium losses as well as the concentrations in serum of both electrolytes were measured before and during the period of infection. 24 hours before appearance of first clinical symptoms of sepsis the sodium concentration in urine increases and the balance becomes negative. Hyponatraemia occurs later and is in correlation with the clinical course of the disease. Thus, the hyponatraemia is caused more by shifting of sodium from the extracellular space than by renal sodium excretion. To prevent this hyponatraemia the sodium intake has to be increased to 6 mmol/kg X 24 h as a minimum and the fluid intake has to be decreased to 80 ml/kg X 24 h as a maximum in the same time when antibiotic treatment is started. A short-term control of serum electrolytes is an important premise for a sufficient treatment. Increased sodium concentrations in urine of more than 50 mmol/l or again increasing concentrations beyond the second day of life can be appreciated as early signs of neonatal sepsis.

Humans↗
PubMed1987

[Pathogen spectrum in bacterial meningitis in childhood and subsequent therapeutic strategy].

In a total of 223 children over one month old suffering from purulent meningitis, there was a predominance (n = 96) of meningococci over hemophilus influenzae (n = 68) and pneumococci (n = 59). Crucial to therapeutic strategy for purulent meningitis is early diagnosis, in our laboratory covering both liquor and blood cultures. Initial therapy has to take account of these three chief causal agents. We have not as yet observed any resistance to penicillin from meningococci or pneumococci, and none of the liquor-cultivated hemophilus influenzae stock has been resistant to ampicillin. In the first two years of life, initial therapy for bacterial meningitis should include ampicillin, a liberal (300-400 mg/kg KM/d) dosage continuing to be important after the onset of improvement. In view of the lack of resistance of the causal agents cultivated, we had hitherto no cell to deploy modern cephalosporins in cases of bacterial meningitis in children.

Anti-Bacterial Agents↗
PubMed1986

[Mycoplasma etiology of acute pancreatitis].

In a 10 year-old girl the clinical and laboratory findings led to the diagnosis of pancreatitis. At the same time an infection by mycoplasma pneumoniae was serologically stated. Since there could not be found another cause for pancreatitis, a relation between pancreatitis and infection by mycoplasms is very probable.

Child↗
PubMed1986

Effects of bacterial sepsis on protein metabolism in infants during the first week.

In the presence of bacterial infection during the first week of life a catabolic state evolves more rapidly than in the later life. Hyperaminoacidaemia and subsequent hyperaminoaciduria, elevated urea concentrations in serum, and increased renal nitrogen losses are the most important metabolic changes. These findings correlate with the clinical course of the disease and refer to the primary disturbance of cell metabolism as the cause of the metabolic changes observed. While no relation could be observed between metabolic response and bacterial species, there is a significant dependence on the time interval from the occurrence of first clinical symptoms at the beginning of antibiotic treatment. If this period is longer than 8 h, serious metabolic disturbances will usually be found. Due to the limited amino acids utilization, especially by the liver, an adequate energy intake should be the primary aim of nutrition, whereas a protein intake of more than 2.0 to 2.5 g/kg X day may further aggravate the metabolic imbalance.

Bacterial Infections↗
PubMed1986

Pneumococcal infections during childhood: serotyping of pneumococcal strains from forty-six children.

The results of serotyping of forty-six strains of pneumococci isolated from children aged 3/12 to 14 9/12 years and diagnosed as having pneumonia, meningitis, primary peritonitis, otitis media, lymphadenitis, osteomyelitis, bacteraemia and conjunctivitis are presented. The results of serotyping and the frequency distribution of the detected serotypes were compared to the particular diagnoses established and the age at which the subjects involved had become ill. Questions of epidemiology and possibilities of immunoprophylaxis are discussed. Finally, the occurrence of pneumococci that are resistant to antibiotic agents are discussed since an isolated strain was found to show reduced susceptibility to penicillin G.

Adolescent↗