PubMed Health⌕ Search

Biomedical subjects

W Hartig

Publications and source records attributed to W Hartig.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Methodological aspects of the determination of nitrogen metabolism parameters from 15N-tracer experiments on swine based on nitrogen metabolism models. 2. Calculation of N metabolism parameters from the time of urinary excretion of 15N].

After a 45-hour infusion of 15N-lysine and 15N-glycine resp. with pigs of 25 kg live weight, the infusion of the tracer was disrupted and a 3-day reduction phase was made part of the experiment. The N-metabolism parameters such as protein synthesis and decomposition quotas were calculated on the basis of the temporal development of 15N-amounts excreted in urine. The labelling and reduction phases were evaluated simultaneously. By means of including the total N-amount of the animal body the balance calculation becomes more stable. The possible influence of the tracer amino acid in connection with the 3-pool-model is discussed on the basis of the ascertained parameters.

Animals↗
PubMed1985

[Our surgical heritage. Max Bürger and surgical pathophysiology. On the 100th birthday of Max Bürger (16 November 1885-5 February 1966].

Max Bürger, born in 1885 in Hamburg, was an outstanding physician in the first half of this century. He markedly influenced many fields in internal medicine. Even in 1922 he investigated the postoperative changes in protein metabolism on the basis of clinical experiments made together with the surgeon M. Grauhan. The discovery of the postoperative loss of nitrogen must be attributed to M. Bürger, not to D. P. Cuthbertson. In 1937 he was appointed to the vacant chair of internal medicine in the University of Leipzig. His work and his great achievements in the medical field were duly appreciated during his life and even after his death in 1966.

General Surgery↗
PubMed1984

[The thyrotropic function of the hypophysis and peripheral thyroid hormones after removal of bland and autonomous nodular goiters].

Bilateral subtotal resection or enucleation or unilateral resection was performed in 60 patients (36 with bland nodular goitre, 24 with autonomic adenoma). The thyrotropic pituitary activity and the peripheral thyroid function were examined in all patients preoperatively and followed up for 12 months postoperatively. The results show that all patients with bilaterally resected bland nodular goitre require postoperative administration of thyroid hormone, since enhanced thyrotropic activity is seen not later than three months after surgery. Since thyrotropic function remains normal in unilaterally operated nodular goitre, thyroid hormone administration does not appear generally necessary. In patients with autonomic adenoma there is postoperatively variability of function, independent of the surgical method employed. In view of possible functional recompensation, final decision on the administration of thyroid hormones should not be made before the end of the sixth postoperative month. These results can be considered as guidelines for a differentiated postoperative management.

Goiter, Nodular↗
PubMed1984

[Small intestinal absorption in cancer patients--basis for enteral feeding therapy in oncology].

A deteriorating nutritional condition combined with the loss of body mass is one of the most noticeable symptoms of cancer. In order to answer the question to what extent absorption disorders in the small intestine are responsible for the malnutrition which develops, we studied 54 oncologic patients using modified D-xylose absorption tests. After the oral and intravenous administration of 10 g D-xylose at different times, the degree of absorption dependent on time was determined on the basis of a biophysical model. When accompanied by general nonspecific tumor symptoms, the frequency of absorption restrictions was increased. An established relation was found between the extent of small intestinal absorption, on the one hand, and the degree of spreading (staging) and the degree of histological differentiation of the carcinoma, on the other hand. Enteral absorption disorders represent a partial cause for the development of malnutrition in cancer patients and must be viewed as a result of a metabolic situation which is distinctly catabolic.

Adult↗
PubMed1984

A modified D-xylose absorption test.

A modified D-xylose-test is described which enables intestinal absorption to be assessed independently of renal and hepatic function. The speed of appearance of the peak of D-xylose-concentration in plasma after an oral administrated dose and the extent of absorption in the small intestine as a time-function, were analysed by graphic-mathematical evaluation of the kinetics of plasma D-xylose concentration after oral and intravenous administration. Small intestinal functional integrity was assessed in 172 normal individuals (aged from 3 to 96 years), also in 9 patients with coeliac disease. The speed and the extent of D-xylose absorption were significantly reduced in all cases of untreated coeliac disease and during relapse. There were no differences between normal individuals and treated patients. Experience over many years indicates that the modified D-xylose-test is a simple, reliable and inexpensive standard method for detecting changes in intestinal absorption.

Adolescent↗
PubMed1984

[Current aspects of the diagnosis of the nutritional status in surgery].

An exact nutritional assessment is a prerequisite for parenteral, enteral or parenteral-enteral nutrition, especially after extended operations or during conservative therapy. By using biochemical methods (visceral proteins), anthropometric measurement (body mass, triceps skinfold, arm muscle circumference, creatinine-index) and immunological procedures (total lymphocyte count and skin testing with recall-antigens) it is possible to determine exactly the nutritional status, severity and type of malnutrition. Furthermore the patients immunocompetence can be evaluated. Determining the digestion and resorption capacity enables the route of application to be chosen.

Adult↗
PubMed1984

[Basis of early enteral feeding in the postoperative period].

Since the conception of a postoperative generalised inhibition of motility of stomach and gut has been disproved, there is a growing support for early enteral nutrition at present. The stomach should be evacuated from increased secretion by tube drainage. This should be combined with intraduodenal tube feeding. Immediately after surgery a sufficient absorption capacity of the small gut also makes early enteral nutrition possible.

Drainage↗
PubMed1984

[Amino acid metabolism in post-stress metabolism].

During the first four days after cholecystectomy 5 patients were nourished totally parenterally with the amino acid solution INFESOL 40 and carbohydrates. The utilization of the applied amino acids were observed by nitrogen balances, amino acid pattern in plasma and urine and other data. It was achieved a positive nitrogen balance at the 3rd postoperative day. The utilization of the amino acids typically was influenced by postaggression metabolism. For the application of INFESOL 40 in the postoperative period (posttraumatic period) some modifications of the amino acid pattern were recommended.

Adult↗
PubMed1984

[Postoperative energy requirements and its fulfillment].

After surgical procedures there are complex and typical changes of the homeostasis, which are summarized as postaggression syndrome. Energy demands in the immediate postoperative period are lower than presumed until recently. After elective surgery the basal energy requirement will increase to about 10 per cent above the preoperative level. Artificial nutrition is used in clinical practice to overcome this. Enteral and/or parenteral nutrition is necessary to meet the energy and nutritional demands in the postoperative period.

Amino Acids↗
PubMed1984

[Modern aspects of enteral and parenteral feeding of newly operated patients].

In a decisive degree the modern trophotherapy further the decrease of the lethality from operation and of the rate of postoperative complications. In the differential indication between parenteral and enteral nutrition at present an international change takes place. The early enteral nutrition after operative interventions of medium severity is a real alternative to the parenteral nutrition. Therapy concepts for the balanced nutrition of newly operated patients are presented. The intake of nutrition via small intestine is less dangerous than via veins and is clearly more economical.

Amino Acids↗
PubMed1984

[Protein turnover in liver failure--determination using the stable isotope 15N].

The 15N-tracer technique gives new opportunities to medical research for investigation of normal and pathological nitrogen metabolism. Analysis of 15N kinetic data derived from total nitrogen excretion in the urine allows to calculate quantitatively certain parameters of protein synthesis and protein metabolism. At the same time analysis of serum samples will allow measurement of 15N-nitrogen incorporation into particular protein or non-protein fractions of the plasma. In the study reported here patients with different liver parenchyme lesions (acute hepatitis, chronic active hepatitis, biliary obstruction, cirrhosis of the liver, hepatic coma) were investigated with a standardized 15N-tracer method developed by us. It could be shown, that protein turnover in patients with liver insufficiency is significantly decreased as compared to healthy persons. Decrease of protein synthesis is associated with a still more pronounced decrease of protein catabolism. There are significant differences in dynamics of 15N in patients with hepatic coma as compared to other patients with liver parenchyme disease without portal encephalopathy. Nevertheless, even in hepatic coma 15N incorporation into plasma proteins can be shown. Differences in the 15N elimination kinetics of the non-protein pool between patients with chronic active hepatitis, biliary obstruction and hepatic coma could be found.

Adolescent↗
PubMed1984

[Functional diagnosis of intestinal absorption in gastroenterology surgery].

Clinical tests for measuring the intestinal absorption in abdominal surgery, especially surgery of the GI-tract, are of great importance. The absorption of the proximal small intestine can be investigated via a modified D-xylose-test. The distal small intestine may be studied by using the vitamin-B12 urinary excretion test. The bacterial overgrowth syndrome and the absorption of bile salts can be diagnosed on the basis of a 14C-glykocholate test.

Biopsy↗
PubMed1983

[Importance of the modern hospital diet in medical practice].

Hospital diet is an essential part of modern therapy in all medical departments. It comprises both the so-called normal diets which are prepared according to modern nutritional knowledge, dietetic foods and the various forms of artificial nutrition (nutrient-defined and chemically defined diets, parenteral and combined nutrition, i.e. enteral and parenteral nutrition). The integration of nutritional therapeutic problems into the treatment of patients requires optimal scientific and practical forms of organisation of nutrition in the clinic. For that purpose, cooperation of clinical, technical, economic and pedagogic divisions is of prime importance. The organisation of patient nutrition in the St. Georg District Hospital in Leipzig is described as a feasible model.

Deficiency Diseases↗
PubMed1983

[Use of tube feeding in surgery].

Tube feeding is a simple and safe method for nutritional support. The efficiency of this procedure depends on the digestion and absorption of the small intestine, optimal choice and nutrients, effective technique and exact supervision. Correct tube feeding can be considered to be an alternative to parenteral nutrition.

Enteral Nutrition↗
PubMed1983

[Standardized 15N-tracer method for the assessment of protein metabolism in clinical practice].

A standardized 15N tracer method is described for the assessment of the nitrogen and protein metabolism in healthy and pathological changed organism. The method represents an isotope technical procedure for the application in the clinical research and practice. The single parts of this routine method are: --the clinical preparation of the patient/proband by means of a standardized nutritional regime, --the tracer administration (single dose) and the sampling (urine, blood), --the 15N-tracer technique (sample chemistry, emissions-spectrometric isotope analysis), --the mathematical evaluation of 15N tracer data.

Blood Proteins↗