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Biomedical subjects

W Heidenreich

Publications and source records attributed to W Heidenreich.

At least 19 recordsLinked to original sources
PubMed1992

[Malaria tropica and pregnancy].

The authors report on a female patient of 26 years of age suffering from malaria tropica infection in her 36th week of pregnancy with fatal outcome. The newborn (after performance of Caesarean section) was infected connatally. Although infections with malaria are rare in Europe today--especially during pregnancy--there is a probability of rising incidence on account of increasing international tourism. Therapeutic problems are expected to multiply due to the resistance of Plasmodia to antiparasitary medication. Additionally pregnancy involves the risk of a more severe course of the disease in the mother. Pregnant women should be discouraged from travelling to countries with malarial risk because of the likelihood of a high rate of abortion, danger of intrauterine retardation, increased incidence of premature deliveries and risk of connatal infection of the newborn. If such warnings cannot be heeded, the persons concerned must be given all relevant information on conventional preventive measures in accordance with WHO recommendations and drug prophylaxis as recommended by a hospital or institution dealing with tropical diseases according to updated standards. The measures to be taken must be adapted to the individual risk of exposure of the patient.

Adult↗
PubMed1991

[Improvement of the mesh-graft method with use of a fibrin glue. Contribution to the surgical correction of vaginal aplasia].

Congenital absence of the vagina can be corrected by covering the walls of the neo-vagina with skin mesh grafts. We performed this operation in 6 patients, of whom 3 had been operated before without success, and used fibrin sealing for hemostasis and fixation of the grafts. The results were very satisfying. In each case the length of the neo-vagina has completely been maintained until now, without any shrinking or shortening.

Adult↗
PubMed1979

Immunological characterization of mononuclear cells in peripheral blood and regional lymph nodes of breast cancer patients.

Mononuclear cells from peripheral blood and draining lymph nodes of 40 patients with invasive locoregional breast cancer were examined for immunological cell surface markers (E, EAhuman, EAox, EAC, SIg pos.). Concomitantly, blood lymphocytes from 36 healthy women and axillary and mesenteric lymph-nodes from patients without malignant diseases were tested as controls. In peripheral blood of tumor patients E rosette-forming cells were slightly diminished as compared to the control group, whereas EAox and EAC rosette-forming cells were increased. These differences may be age-dependent rather than tumor-related. In the draining lymph nodes of breast cancer patients as well as in the control lymph nodes, the percentages of EAC rosette-forming cells and SIg positive lymphocytes were significantly increased compared to peripheral blood, whereas E and EAhuman rosette values remained unchanged. Percentages of EAox rosettes on the other hand were strongly diminished in the draining lymph nodes, suggesting that the EAhuman and EAox rosetting techniques detect 2 types of Fc-receptor bearing cells. No significant differences were found between the cell surface marker analysis of tumor-free and metastatic lymph nodes of breast cancer patients and the control lymph nodes.

Adult↗
PubMed1979

Immunological characterization of mononuclear cells and morphological findings in patients with mammary carcinoma.

Mononuclear cells from peripheral blood and draining lymph nodes of 40 patients with invasive mammary carcinoma were examined for various immunological cell surface markers including surface membrane immunoglobulins and rosetting properties (E, EA, EAC). No significant relationship could be established to anyone of the following criteria for which the literature reports varying prognostic values: Clinical staging of the disease , histological tumor type, grading, nuclear differentiation, round cell infiltration, perivenous infiltration, sinus histiocytosis, and lymph node reaction patterns (lymphocyte predominance, germinal center predominance, lymphocyte depletion, unstimulated nodes). From the reported results it is concluded that the analysis of lymphocyte cell surface markers in mammary carcinoma is not a suitable parameter for supporting the existence of specific or unspecific anti-tumor immune reactions which may be suspected from certain histological reaction patterns.

Breast Neoplasms↗
PubMed1979

[Effect of therapy on the lymphoid cell distribution in the venous blood of breast cancer patients].

Rosetting properties (E, EAh, EAox, EAC rosettes) and presence of surface immunoglobulins (SIg) were examined on peripheral blood lymphocytes from 30 breast cancer patients immediately prior to therapy and 4 weeks thereafter. Therapy consisted of limited radical surgery followed by combined X-ray and telecobalt radiotherapy. The results were compared to patients who had received the same treatment 1 year ago (n = 13), 2 years ago (n = 13) and 3 to 10 years ago (n = 20). All irradiated patients exhibited a considerable leuko- and lymphopenia with a particular decrease of E and EAh rosettes, and a concommittant relative increase of EAox and EAC rosettes. SIg positive cells showed no significantly different percentages before and after therapy although in absolute counts they were similarly reduced as the other subpopulations after radiotherapy. The possible prognostic influence of radiation induced lymphopenia is discussed without coming to clear conclusions.

B-Lymphocytes↗
PubMed1979

[Breast biopsies which failed to show cancer (author's transl)].

A review is presented on 520 patients who had biopsies of the breast which did not show cancer between 1972-1974. These patients are compared to 304 patients whose biopsies definitely showed cancer of the breast and 520 patients who came to the hospital because of well defined gynaecological disease such as uterine fibroids or uterine prolapse. Comparison of these groups regarding age, past history, indications for the biopsy showed that patients with a biopsy without proof of cancer are difficult to follow for diagnosis. Follow-up on these patients is difficult, however, it is important since up to 4% of these patients with previous negative biopsies later have cancer of the breast. A decrease of biopsies in favor of non-surgical diagnosis of breast lesions can only be recommended under optimal conditions. Under other circumstances the risk of cancer of the breast is high enough to justify a liberal indication for breast biopsies.

Adult↗
PubMed1978

[Imprint cytology of axillary lymph nodes in breast neoplasms for intraoperative rapid diagnosis].

A total of 385 lymph nodes of patients suffering from breast cancer were examined intraoperatively for the presence of metastases. We applied imprint cytology and stained using the "Diff-Quick" set (3 times 30 seconds). The percentage of correct identifications following instant cytological examination amounted to 94.5 if compared with subsequent paraffin histology. The 21 diagnostic failures were composed of 3 false negative and 18 false positive results. These data make the advantages for routine clinical application quite obvious.

Axilla↗
PubMed1977

[The hidden intrauterine device].

The hidden intrauterine device (IUD) may result because of disapperance of the tails into the uterus, unobserved loss of the device and perforation. The localization can be estimated by sonography, x-ray and probing of the uterine cavity. In most of the cases the device can be removed without hospitalization, surgical procedures are rarely neccessary. If pregnancy did occur the hidden intrauterine device cannot be removed without termination of the pregnancy in most cases.

Female↗
PubMed1977

[Germ cell tumours in gonadal dysgenesis (author's transl)].

In a 17-year-old patient gonadal dysgenesis with a XY-karyotype was diagnosed by laparoscopy and chromosomal analysis. Two years later, the patient came again to the hospital because of a large tumour which proved to be a dysgerminoma. Except dysgerminomas, other germ cell tumours are also found in gonadal dysgenesis, for example gonadoblastomas, which consist of germinal cells, Sertoli-granulosa-cells and interstitial cells. In most cases of gonadal dysgenesis with a germ cell tumour a Y-chromosome is present. The risk of a gonadal tumour in such cases is estimated to be 25%. In gonadal dysgenesis with a Y-chromosome a prophylactic extirpation of the gonads is necessary, which should be combined with a hysterectomy.

Adolescent↗
PubMed1977

[Disordant monozygotic twins with Mayer Rokitansky Kütser syndrome (author's transl)].

Two patients with vaginal agenesis are reported. Each had a normal twin. In one case, a Mayer Rokitansky Küster syndrome could be diagnosed by laparoscopy. In the other case it was probably the same syndrome. Monozygocy of the two pairs of twins was shown by examination of features of serum proteins, serum enzymes and erythrocytes with a probability of 99,8% and 99,1%. Only three other cases of discordant twins with MRK syndrome were reported in the literature, at least two of them monozygotic. Extremely rare cases of familial MRK syndrome were also found. Discordance of monozygotic twins makes a genetic etiology unlikely.

Adolescent↗
PubMed1977

[Increasing individualization of the treatment of carcinoma of the endometrium (author's transl)].

Metrium seen from 1969 to 1973 are reported. These results were compared to the results of treatment of carcinoma of the endometrium at the same institution between 1944 and 1960. There was a considerable increase of the mean age of the patients. Consequently the operability was reduced to 74.3%. The necessity to resort to primary radiotherapy rose to 25.7%. Diseases of old age were contra-indications to operative treatment. In cases generally fit for operation the contra-indications to vaginal surgery increased. Vaginal hysterectomy was therefore only employed in 78.5% of the operations. An individualization of the treatment of carcinoma of the endometrium is recommended. Continually good or improved results of the treatment are expected by individualization in the group of patients which already showed impaired health by age or concomittant diseases.

Age Factors↗
PubMed1977

[The optimal treatment of carcinoma in situ of the uterine cervix (author's transl)].

The results of treatment of carcinoma in situ of the uterine cervix in 380 patients seen between January 1, 1966 and December 31, 1973 are reported. There were 134 women age 40 or less. There were 246 patients age 40 or older. In 334 patients a total hysterectomy with removal of a vaginal cuff was carried out (87.9%). A large therapeutic cone biopsy was done in 46 patients (12.1%). In the 334 patients treated by hysterectomy, 2 recurrent carcinomas in situ of the vaginal vault were observed (0.6%). In 16 of the cases treated by conization later suspicious colposcopic and/or cytologic findings made hysterectomy necessary. In 5 of these cases a recurrent carcinoma in situ was likely. The postoperative morbidity after total hysterectomy was low. There was no postoperative death. The total vaginal hysterectomy with removal of a vaginal cuff is recommended as treatment for carcinoma in situ of the uterine cervix in order to avoid the diagnostic difficulties in the follow-up after treatment by conization and because of the low recurrence rate after hysterectomy. Conservative treatment should only be employed in patients who desire later child bearing. tthe psychological stresses of the continually required follow-up examinations after conization should not be underestimated.

Adult↗
PubMed1976

[Diagnosis of breast carcinoma. Value of x-ray findings for the diagnosis of carcinoma in situ of the breast from the clinical point of view].

The x-rays-results of 35 mammae with a carcinoma in situ are presented and compared with those of 2 groups without carcinoma. In contradiction to invasive malignancies the carcinoma in situ do not show pathognomonic signs on x-ray examination. However, suspicion is raised by the appearance of microcalcifications and by striped differences in tissue density. These findings should compell to perform a biopsy, even though the clinical and roentgenologic findings may otherwise suggest a fibrocystic disease. Therefore, provided the discrete signs described in this paper are carefully considered, the technique of mammography may contribute to the pre-operative presumptive diagnosis of carcinoma in situ.

Adult↗
PubMed1976

[Psychosocial problems of young patients with aplasia vaginae (author's transl)].

10 patients with aplasia vaginae et uteri (Mayer-Rokitansky-Küster-syndrome) were interviewed by 2 psychologically trained persons. Vaginoplasty had already been performed in 8 patients. For these patients, the time between their first consultation of a doctor and vaginoplasty had been rather difficult. During this time, they had the strong feeling of being different from other girls. This feeling was favoured by the lack of information about the kind of their anomaly and the operation. The preoperative well informed patients possibly tolerated the painful application of vaginal prosthesis better than others. All patients with aplasia vaginae et uteri had many questions concerning their exspected sexual relations. Their knowledge on sexual function was very poor. We think, that cooperation between gynecologist and psychologist or psychiatrist is necessary for good results in treatment of patients with the Mayer-Rokitansky-Küster-syndrome.

Adolescent↗
PubMed1976

[Clinical problems of the breast carcinoma in situ].

A report of carcinoma in situ of the breast, including problems of diagnosis and treatment. Over a 6-year period cut of a total of 743 carcinomas of the breast, 77 carcinomas in situ were observed. The difficulties of diagnosis are reviewed. Treatment consisted of simple mastectomy. In view of the inadequate therapeutic results it is recommended that a modified radical mastectomy should also be done in all cases of carcinoma in situ of the breast. The pros and cons of postoperative radiation are discussed.

Adolescent↗