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Biomedical subjects

W Heinkelmann

Publications and source records attributed to W Heinkelmann.

15 recordsLinked to original sources
PubMed1979

Experimental studies on the use of microwaves for the localized heat treatment of the prostate.

High frequency tumor therapy requests heating of a well defined area, whereas the surroundings should be unaffected. This sort of therapy should be more tolerable than a whole body heating. For this purpose a new developed microwave applicator (433.9 MHz) for local heat application was tested in animals. Using this rectally insertable applicator the prostate of dogs were irradiated. The temperature of the rectum, the urethra and the prostate were measured and recorded using specially developed thermistor probes. The effect of hyperthermia on the prostate and the surrounding tissue was analyzed macroscopically and micromorphologically. It was shown that local heating of the prostate of dogs is possible. The induced damages of the prostate and surrounding tissue is not severe enough to be untolerable.

Animals↗
PubMed1976

[The effect of proteinase inhibitors in the early stage after experimental myocardial infarction (author's transl)].

Our experiments have shown that in cats in the early phase after experimental myocardial infarction, the volume of extravascular fluid increases in the lungs while the intravascular volume decreases. A hemoconcentration developed with increased hematocrit and a fall in plasma volume. The thrombocyte count fell continuously during the first 4 hours after the infarction. The CPK activity in the region of the myocardial infarct was reduced in comparison to uninfarcted tissues. Intravenous injection of 50,000 KIU/kg Trasylol within 20 minutes after the infaction caused a significant reduction of the extravascular fluid in the lungs. All the other parameters were not changed by Trasylol administration, with the possible exception of the fall in thrombocytes which seemed to be slowed after Trasylol.

Animals↗
PubMed1975

[Contractility of the surviving myocardium following experimental infarct].

The contractile function of the non-infarcted myocardium was examined in adult cats following myocardial infarction produced by ligation of several branches of the LAD and circumflex coronary artery. Two and seven days following infarction, after determination of intracardiac pressures, papillary muscles were excised from the non-infarcted portion of the right ventricle and transferred into a myograph for analysis of contractile function. One week following infarction, force-velocity relations of the surviving myocardium showed a shift downward and to the left in comparison to sham-operated controls. At the same time, there was a decline in actively developed force at Lmax to be deserved, which appeared to be caused by a decrease in the rate of force development. Two days following infarction, similar changes were to be observed, although to a lesser extent. There appears to be a distinct loss of contractility in the remaining viable myocardium following experimental infarction.

Animals↗