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Biomedical subjects

W Heinrich

Publications and source records attributed to W Heinrich.

13 recordsLinked to original sources
PubMed1991

Clinical relevance of biological incompatibility and role of a central register.

Different aspects relevant for the assessment and characterization of biomaterials are presented. Quite a number of basic concepts that play an important role when detecting unwanted adverse effects of drugs have to be taken into consideration when registering and evaluating unwanted effects of biomaterials. The institutionalization of the Central Bioregister at the University of Saarland is described. This Bioregister is a so-called "spontaneous" ad hoc recording system whose efficiency depends largely on the collaboration of physicians. Thus, the efficiency and rationality of the use of biomaterials can certainly be improved. The possibility of registering even rarely occurring unwanted effects as well as new indications will result in and allow a more general and/or a more specific therapy, depending on the biomaterial.

Adverse Drug Reaction Reporting Systems↗
PubMed1991

[Disease and injury in the late middle ages in Eggenburg, lower Austria].

From the skeletal remains of about 5800 individuals from the charnel house of Eggenburg there were 2200 individuals of late medieval date. These were checked for injuries and pathologies. Of the skulls 410 showed various injuries and 430 pathologies. These pathologies could be differentiated into 20 groups. The frequencies of injuries (18.7%) and pathologies (19.5%) were very similar in the skulls, which contrasted with those in the 11600 long bones of 0.5% injuries and 3.8% pathologies. On the whole the degree of expression of the traumatic lesions and of the pathologies was slight to medium.

Austria↗
PubMed1990

[Inductive stimulation].

Electrical stimulation, which has long been known, has recently been complemented by electromagnetic stimulation. This method is based on the law of induction and employs coils in place of electrodes. The effect of this process is deduced from both the relationship between magnetic and electrical fields and the stimulating effect. A new type of stimulator has been developed from a resonant circuit, thus allowing nerves to be excited with low-frequency pulses up to fusion frequency.

Animals↗
PubMed1989

LET spectra of cosmic-ray nuclei for near earth orbits.

Measurements of cosmic-ray LET spectra were part of the radiobiological space research programs during the Spacelab 1 (SL-1) and the D1 missions. We analyzed CR-39 plastic nuclear track detectors of the Advanced Biostack experiment of SL-1 and of the Dosimetric Mapping and Carausius morosus experiments in the BIORACK on D1. The particle tracks in the CR-39 were detected and measured by an automatic scanning and measuring system. An in-flight calibration was derived from track measurements of minimum ionizing oxygen and iron nuclei and of stopping nuclei as a function of the residual range. LET spectra measured at different locations in the space shuttle are presented and discussed for both missions. A model describing the effects of the geomagnetic field of the earth on charged cosmic-ray particles and the shielding by matter is used to calculate LET spectra for the two missions and for typical space station orbits at low inclinations. A comparison of measured LET spectra and LET spectra calculated for different flight parameters shows that besides geomagnetic shielding the shielding by matter is most important in comparison to solar modulation and to variation of particle flux with flight altitude. Model calculations must be improved and must consider more detailed sectored shielding by matter and the influence of trapped radiation. The last item is of importance in the case of low-inclination orbits.

Cosmic Radiation↗
PubMed1986

COMAP: a comigrating analysis program for estimating the relationship of adenoviruses on the genome level.

The computer program COMAP is described that enables one to evaluate the relationship among adenovirus 6 strains by comigration analysis with regard to the genome. The required data were obtained by restriction analysis with several enzymes. The program is also important for identifying further adenovirus strains by DNA restriction analysis and to compare new restriction fragment patterns with stored data of known adenovirus strains. We believe that in this manner the DNA restriction analysis will become a valuable diagnostic procedure.

Adenoviridae↗
PubMed1975

[Pharmacokinetics and action of digitoxin and ouabain in the isolated hearts of guinea pigs and rats].

Isolated guinea pig and rat hearts were perfused with 3H-digitoxin and 3H-ouabain. After varying perfusion periods (3-90 min) the glycoside content in the tissue was determined. With digitoxin the tissue/medium-ratio at equilibrium was found to be 14 in guinea pigs and 8 in rats, with ouabain the corresponding values were 2 and 1. In further experiments the efflux of radioactivity from isolated perfused hearts preloaded with 3H-glycosides was measured in 3 min intervals. A compartmental analysis was carried out. The efflux could be described by the sum of two exponentials indicating the existence of two compartments. The half lives of compartment 1 (2.1-4.0 min) and those of compartment 2 (16.8-20.6 min) were similar with both glycosides and both species. The development and decline of the positive inotropic effect in guinea pig hearts exhibited a time course similar to that of the glycoside content in compartment 1: the time for reaching the half maximum effect was 3-4 min with ouabain and 5-6 min with digitoxin. It is suggested that compartment 1 represents the site of the positive inotropic action of cardiac glycosides.

Animals↗