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Biomedical subjects

W Heinze

Publications and source records attributed to W Heinze.

At least 19 recordsLinked to original sources
PubMed1992

[Fatal pulmonary embolism after lysis therapy in post-traumatic renal vein thrombosis].

A 30-year-old man was hospitalized because of increasing dyspnoea for 4 weeks. Chest X-ray demonstrated an infiltrate in the right upper lobe and enlargement of the central pulmonary arteries. Lung perfusion scintigraphy revealed, typical of embolism, absent perfusion of the entire right upper lobe, as well as segmental embolism in the left upper and basal lobes. Phlebography of the legs and pelvis was unremarkable. Intravenous heparin treatment was begun (initially 1,250 IU/h, then dosage adjusted according to the partial thromboplastin time). Nonetheless the patient's condition deteriorated the next day and the respiratory failure increased (pO2 61 mm Hg despite oxygen supply). Streptokinase was then infused in ultra-high dosage, 9 million units over 6 hours. But the patient died of cardiocirculatory failure 4 hours after the streptokinase infusion had been finished. Autopsy revealed fulminant recurrent pulmonary embolism with occlusion of the right main pulmonary artery. The emboli had their origin in renal vein thrombosis extending into the inferior vena cava, which had probably been caused by slight trauma to the flank during a game of squash 6 weeks previously.

Adult↗
PubMed1988

[Familial hypertrophic obstructive cardiomyopathy].

The diagnosis of hypertrophic obstructive cardiomyopathy in a 50-year-old man was confirmed by left-heart catheterization and echocardiography, the diagnosis having first been made some years earlier. Both his brother and his children have the same disease. The patient had several cardioversions for recurrent atrial fibrillation with a rapid ventricular rate. Because conservative treatment failed to give a satisfactory result, transaortic myotomy and myectomy were performed. Clinical examination eight months postoperatively showed that the patient's general condition had markedly improved, there was sinus rhythm, and the signs of left ventricular hypertrophy had regressed.

Cardiomyopathy, Hypertrophic↗
PubMed1985

[Intramural pseudodiverticulosis of the esophagus. Clinical aspects, morphologic changes and functional disorders].

Oesophageal intramural pseudodiverticulosis, a rare benign disease with as yet unexplained aetiology, was observed in 4 patients during the course of 2 years. The main symptom is dysphagia. Radiographic and endoscopically detectable diverticula or diverticular orifices are pathognomonic. A prolongation in the duration of oesophageal contractions is the main manometric finding. At autopsy, a reduction in the number of oesophageal intramural ganglion cells was seen in one case. A prolonged pressure-effect on the oesophageal wall could be the cause of the wall pouches.

Adult↗
PubMed1982

[Subacute and subchronic percutaneous tolerance testing (28-day and 90-day test) of epicutaneously applied dis-infectants as demonstrated by the example of peroxyethanoic acid (author's transl)].

As compared to control animals, guinea-pigs to the shaved backs of which a dose of 0.16 ml of a 0.12% solution of PES/100g. of body mass had been applied twice daily for periods of 28 and 90 d, respectively (5 d of application being followed by 2 d without treatment), showed erythema, loss of hair, slower increase in mass, increased heart rate, smaller body mass/kidney mass and body mass/spleen mass ratios, increases in leucocytes, ASAT, ALAT, LDH I and LDH III. In the 28-d test, slight inflammatory symptoms of the liver, kidneys and heart were observed in the experimental animals. These symptoms were more marked in the 90-d test, granulomata in the livers being particularly striking. A pneumonia of moderate to very marked degree is suggestive of the activation of a clinically latent PES infect whereby the inflammatory alterations in the kidneys might be explained by the formation of metastases.

Acetates↗
PubMed1981

Lipomatosis of the pancreas. A morphometrical investigation.

The study was performed in 50 human autoptic pancreata. After postmortem ductography and formalin fixation the organs were cut in slices of 8 mm thickness. After paraffinembedding histological sections were made from these slices. In photographical magnification (20 X) of these sections the amount of adipose tissue and pancreatic parenchyma were measured by morphometric means. The length of the pancreatic duct was determined in the radiographs. The data were evaluated by statistical methods. The share of the adipose tissue and the total weight of the pancreata are positively correlated depending on age and body weight. In contrast the weight of the pancreatic parenchyma shows no correlation to age, body length and weight. The amount of lipomatosis is the same in the various parts of the dorsal pancreatic anlage. On the other hand, the amount is clearly diminished in the ventral anlage. In the lipomatous pancreata the main duct is longer than in the normal. The lipomatosis of the pancreas is not correlated with a loss of parenchyma, which means, that there is not a true lipomatous atrophy. Even if the parenchyma in the lipomatous pancreata is replaced by fat tissue, which includes the undestroyed pancreatic islets, the parenchymal weight of the pancreas remains unchanged. This and the lengthening of the pancreatic duct in lipomatous organs allow the conclusion that the loss of parenchyma may be compensated by new parenchymal growth.

Adipose Tissue↗
PubMed1980

[Pharmacokinetic model studies of sulfamerazine in domestic mammals. 3. Acetylation, protein binding, and minimal inhibitory concentration of sulfamerazine].

Acetylation and protein fixation were established for the purpose of elucidating the chemotherapeutically effective part of sulphamerazine when applied to cattle, swine, horse, sheep, dog, and cat. The highest degree of acetylation and lowest protein fixation in all species tested, were recorded from swine. A reciprocal correlation was found to exist between the two above parameters, and it was statistically secured, except for horse. A mathematical description of the functional relationship between sulphamerazine fixed to serum protein and free sulphamerazine was possible by means of the Freundlich isothermia which had been recommended by SCHOLTAN (1962) in the following form: cgeb = K+ . cfreim The problem of minimum inhibitory concentration is discussed and explained in greater detail by computational examples with Escherichia coli.

Acetylation↗
PubMed1980

[Pharmacokinetic model studies of sulfamerazine in domestic mammals. 2. Elimination of Mebacid 200 and Mebacid tablets following oral, subcutaneous and intramuscular administration].

The mathematical foundations underlying pharmacokinetic testing and acceptance of medicaments for domestic mammals are expounded and discussed, with reference being made to examples of intramuscular, subcutaneous, and oral application of Mebacid 200 and Mebacid tablets. Elimination of sulphamerazine may be mathematically described by means of the following bi-exponential function: c = B x e-k2 x t -- A x e-k1 x t The concepts of the mono-compartmental model "Extravasal Application" can be claimed as being of basic validity. Blood levels established after intramuscular and subcutaneous application of sulphamerazine-sodium (Mebacid 200) were lower than those recorded after oral application of Mebacid tablets. The half-lives of elimination, following oral application to big animals of Mebacid tablets, were longer than those following intravenous application of comparable injection solution.

Administration, Oral↗
PubMed1980

[Pharmacokinetic model studies of sulfamerazine in domestic mammals. 1. Elimination of Mebacid 200 following intravenous administration to large animals].

Pharmacokinetic data of sulphamerazine were recorded from eight heads each of calf, adult cattle, horse, and sheep, following intravenous application of Mebacid 200, and mathematical implications were discussed. Exponential excretion was recorded from all species, according to the following equation: c = B x e-k2 x t The most favourable pharmacokinetic parameters were recorded from calf.

Animals↗
PubMed1980

[Pharmacokinetic model studies of sulfamerazine in domestic mammals. 4. Mebacid tablet and Mebacid 200 dosage calculation problems].

The highly variegated complex of aspects relating to dosage calculation for veterinary drugs is explained and discussed by examples of Mebacid 200 and Mebacid tablets. For domestic mammals, a dosage interval of 24 hours is desirable for reasons of economy. Therefore, due allowance must be made, by means of unilateral confidence, of the most unfavourable case of high protein fixation, low half-life for elimination, and high coefficient of distribution. The following equation, proposed by DETTLI and SPRING (1966) was used for dosage calculation: AD = c . delta' . ek2 . t or ED = c . delta' . (ek2 . t -1) The dosage will now be in a twelve-hour rhythm, because of the low half-life for elimination of sulphamerazine-Na. A pharmacokinetically founded dosage interval of 24 hours will be feasible only by oral application of Mebacid tablets. The difference between the calculated initial and maintenance doses was found to be negligible.

Animals↗
PubMed1980

[Pharmacokinetic model studies of sulfamerazine in domestic mammals. 6. Absence of drug residues].

The problem of no residues is elucidated and discussed under pharmacokinetic aspects. An equation with due consideration confidence by which to calculate the absence of residues in drugs is given under the assumption that elimination of such residues should follow the concepts of the monocompartment model. The time is calculated by which all residues of sulphamerazine have disappeared, following application of Mebacid 200 and Mebacid tablets to farm animals.

Animals↗
PubMed1978

Long term treatment of Huntington disease with L-glutamate and pyridoxine.

Decreased levels of gamma aminobutyric acid (GABA) and its synthetic enzyme, glutamic acid decarboxylase, have been found in the brains of patients with Huntington disease. In an attempt to augment GABA-mediated neurotransmission, daily doses of 25 gm of L-glutamate (the substrate for glutamic acid decarboxylase) and 500 mg of pyridoxine, its cofactor, were given to five patients with Huntington disease. This regimen was continued for 2 years. Assessment of motor and behavioral function indicated no improvement on this regimen.

Adult↗
PubMed1977

Quantitative extraction of morphologic cell parameters from the diffraction pattern.

A new technique for the fast and quantitative extraction of cell parameters from diffraction patterns was applied to cervical gynecologic material. Based on radial scans through the diffraction pattern, this technique permits the simultaneous determination of the nuclear and cytoplasmic diameter by Fourier analysis of the radial scanning signals after compensation for the intensity falloff by an amplification which is proportional to the third power of the radial position in the diffraction plane. In addition, a correlation between the angle of the highest amplitude of the scanning signals and the coarseness of microstructures in the cell was observed. Illustrative examples of measurements on exfoliated cells of different type are presented.

Cell Nucleus↗
PubMed1976

[Comparative morphological studies on the vascular systems of testes in cattle, swine, horse and dog under functional conditions].

The metacrylate and latex corrosion techniques were used to establish that the vascular system of testes is based on one coherent principle in common domestic mammals. The cone-shaped Plexus pampiniformis consists of numerous venous rami, between 0.25 mm and 1.0 mm in thickness and forming a dense vascular network, which practically encase the spiral-shaped A. spermatica interna (cooling coil principle). The testicular veins and arteries in the Tunica albuginea constitute a somewhat voluminous layer of vessels for dissipation of heat, with rami branching off radially into the testicular parenchyma. Most of the artieral rami with radial penetration of the testicular parenchyma turn towards the surface in the mediastinum testis for three-shape ramification. The vascular rami are characterised by countless meanders, primarily for temperature control, pulse flattening for more regular and even blood flow, and blood reflex pumping.

Animals↗