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Biomedical subjects

W Helbing

Publications and source records attributed to W Helbing.

14 recordsLinked to original sources
PubMed1998

Autologous pericardium for ventricular septal defect closure.

BACKGROUND AND AIMS OF THE STUDY: The use of living, untreated autologous pericardium for patch repair in the left ventricular outflow tract was considered attractive in children. METHODS: Ventricular septal defect (VSD) closure with an untreated autologous pericardial patch was performed in 102 children of mean age 13.4 months (range: 1 to 73 months). Postoperative transthoracic Doppler echocardiography was performed in all children at a mean of nine weeks (range: one day to 50 weeks) after surgery. One pericardial patch, which was explanted at autopsy two months after surgery, was studied microscopically. RESULTS: At short-term follow up, no or only minor residual VSD was found in 97 patients, moderate VSD in two and severe VSD in one patient. One patient was reoperated for residual VSD and an aneurysmic patch first diagnosed seven days after surgery. Two more patients showed ballooning of the patch without VSD after five and seven days respectively. All aneurysmic patches were attributed to intraoperative patch oversizing. Patch integrity was confirmed in all other patients. No inflammatory or degenerative changes were observed at microscopy, rather a remodeling response had caused the patch to thicken, indicating an adaptation of the living tissue. CONCLUSIONS: The untreated autologous pericardial patch has shown to be a safe alternative for VSD closure, provided that the patch is properly sized.

Echocardiography, Doppler↗
PubMed1983

[Control of follicle maturation by estrogen determination in the serum and urine during treatment with gonadotropins].

Determinations of estrogen concentration in urine or serum for estimation of follicle maturity is a precondition for treatment with gonadotropines. -- Both methods determination are retrospectively compared in 22 cases. Only the RIA-method of 17 beta-estradiol determination is capable to recognize an overstimulation with a high rate of reliability, because the evidence of total estrogens in urine lags behind. Clinical tests such as Insler-score don't indicate chemical overstimulation.

Adult↗
PubMed1983

[Changes in the automatically analyzed features of fetal heart rate patterns and fetal movements as influenced by atropine sulfate].

The influence of atropine sulphate (0.01 mg/kg body weight of pregnant women i.v.) on several parameters of fetal heart rate was investigated with automatic analysis of FHR. Fetal movements were counted, too. After administration of atropine, there was a first period with an "inverse" effect of atropine in all fetuses: decrease in baseline FHR (5.1%, minimum after 4.5 min) and increase in the amplitude of FHR fluctuation (44.6%). Thereafter, in a second period the "true" atropine effect appeared: increase in baseline FHR (15.5% above the level before atropine maximum after 25.1 min) and decrease in the amplitude of fluctuation (64.5%). In the third period baseline FHR returned to normal values but the amplitude of FHR fluctuation as well as the beat-to-beat irregularity remained small in 12 from 14 fetuses. Fetal movements registered by the mothers decreased significantly in this time. The results demonstrate a dualistic effect of atropine in the fetus. Moreover, the amplitude of FHR fluctuation (amplitude of macrofluctuation) and the beat-to-beat irregularity (microfluctuation) changed in an equal manner and appear to be influenced by similar regulatory processes. The divergence in the reaction of the baseline FHR and the amplitude of fluctuation together with a decrease in fetal movements might be caused by a central nervous effect with a change in the behaviour of the fetus.

Atropine↗
PubMed1975

[Radical surgery in unseccessfully irradiated cervix carcinoma?].

When radiological treatment in carcinoma of the cervix has failed radical operation may still be technically feasible in certain cases. They are, however, always prone to complications resulting from tissue damage due both to radiation and surgery. Among the 6 cases described there was one double-sided necrotic fistula of the ureters and two vesical-colonic-vaginal fistulae. In two patients we observed extended necroses of the pelvic tissue 5 and 7 weeks respectively after the operation with preceding telecobalt therapy; in one case this resulted in bleeding to death. There was only one case without any complications. This had been treated before by contact therapy only without additional percutaneous radition. From this we would like to draw the conclusion that one should refrain from secondary radical operation after telecobalt therapy. The question remaine to be discussed whether in these cases ultra-radical exenteration can be successful.

Adult↗