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Biomedical subjects

W Hendry

Publications and source records attributed to W Hendry.

7 recordsLinked to original sources
PubMed1991

Morphometry of bladder carcinoma: morphometry and grading complement each other.

Subjective grading of bladder carcinoma is a good predictor of the clinical outcome in those patients whose tumours are grade 1 or grade 3. However, in grade 2 tumours, which account for 45% of cases, grading has little predictive value in an individual patient. We have complemented the use of subjective grading with measurement of nuclear area and used a calculation of the distribution of nuclear sizes as a predictor of the clinical course. When subjective grading was complemented by morphometry the outcome was correctly predicted in 55 of 58 cases and all cases with poor clinical outcome were identified.

Carcinoma, Transitional Cell↗
PubMed1986

Prognostic factors in stage I non-seminomatous germ-cell testicular tumors managed by orchiectomy and surveillance: implications for adjuvant chemotherapy.

Between February 1979 and March 1985, 126 patients with clinical stage I non-seminomatous germ-cell testicular tumors were entered into a surveillance study after orchiectomy. Of this group, 36 (28%) have relapsed. The prognostic significance of 13 clinical, histopathologic, and biochemical factors has been analyzed. Vascular invasion and lymphatic invasion (LI) within the primary tumor, histology, and involvement of the epididymis and rete testis were significantly associated with an increased risk of relapse. However, multiple regression analysis showed that only histology and LI were significant, independent prognostic factors. These findings provide the basis for the consideration of adjuvant chemotherapy for patients with apparent clinical stage I testicular non-seminoma who are at high risk of harboring occult metastases.

Adult↗
PubMed1986

Intracardiac metastases from malignant teratoma of the testis.

Cisplatin-based chemotherapeutic regimens are highly successful at controlling testicular teratomas, returning tumor markers to normal in 76% of patients. However, bulky residual disease persists in 24%, and surgical excision of these deposits is becoming increasingly common. This approach is justified, because the histologic characteristics of such deposits gives valuable prognostic information, allowing a decision to be made regarding additional therapy, and relapse of apparently stable disease may occur. Excision of residual bulky disease may be achieved safely. We have recently successfully excised an intracardiac metastasis in a patient with no demonstrable extrathoracic disease and normal serum marker levels.

Adult↗