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Biomedical subjects

W Herrmann

Publications and source records attributed to W Herrmann.

At least 91 records · Page 5Linked to original sources
PubMed1986

[Postprandial hyperlipemia, circadian rhythm and the stress test in lipid metabolism].

Functional tests and daily profiles allow more exact insights for the diagnostics and management of the therapy in disturbances of fat metabolism than the momentary establishment of the fasting lipids. Circadian rhythms are reported particularly for lipoproteins rich in triglycerides, triglycerides, HDL fractions, lipolytic and lipogenic enzymes. The postalimentary hypertriglyceridaemia depends upon the distribution and the composition of food as well as upon individual differences (e.g. sex). The connection to the HDL metabolism is of particular importance. The interaction of the lipoprotein fractions in the circadian course has still many open questions. Results with an oil tolerance test are presented and discussed.

Adipose Tissue↗
PubMed1986

[Triglyceride profile following oil administration].

27 normolipaemic females (average age 33.5 years), 26 normolipaemic males (average age 40.2 years) and 29 male patients with cardiovascular diseases (average age 48.9 years) were examined. In all persons an oral tolerance test with 75% sunflower oil was performed. After 6 and 8 hours the control of the postprandial hypertriglyceridaemia was performed. The average fasting values and the postprandial deviations show a clear degradation--females, males, patients with cardiovascular diseases. Between the size of the triglyceride deviation after load with edible oil and the HDL-cholesterol concentration in the fasting serum there is a significant negative correlation in patients with cardiovascular diseases and in normolipaemic males, which is not to be recognized in the group of the normolipaemic females. The authors are of the opinion that HDL cholesterol is also an indicator for the speed of the destruction of triglyceride-rich lipoproteins. At the end of a 4-week swimming training of 20-30 minutes a day, 6 times a week, in the patients with cardiovascular diseases a significantly improved fat tolerance and thus a round increase of the lipolytic capacity could be proved.

Adult↗
PubMed1986

[Treatment of disorders of lipid metabolism with the new lipid regulator X50].

With the newly developed lipid regulant X 50 = 1-benzyl-3-(1-carboxyl-methylethoxy)-4-methylpyrazol 15 patient with primary hypercholesterolaemia and hypertriglyceridaemia were treated for 3 months. A significant decrease of the serum triglycerides by 47% in all patients and of the total cholesterol by 32% in half the patients (LDL cholesterol decrease 25%) was the result. Altogether an increase of the linoleic acid of 14% and a decrease of the uric acid of 16% were furthermore the result. There were practically no side effects.

Apolipoproteins↗
PubMed1986

[Lipids and apolipoproteins in relation to the degree of coronary sclerosis].

86 male patients with 0-, 1-, 2- or 3 vascular disease who underwent coronary angiography as well as a control group were examined with regard to their lipoprotein constellation: total (TC-), LDL-, HDL-, beta- and alpha-cholesterol (C); triglycerides; apolipoproteins A, AI and B. Significant differences between the mean values of the control group and the patients with coronary disease were found for the groups with 2- and 3-vascular disease for the following parameters: TC, HDLC, TC/HDLC, LDLC/HDLC, alpha-C, TC/alpha-C, beta-C, alpha-C. The quotients TC/HDLC and TC/alpha-C most closely correlate with the degree of the coronary sclerosis. In the apolipoproteins A, B and the index Apo B/A the patients with coronary disease of the groups 0-3 possess equally lowered or increased serum levels and number values, respectively, in comparison to the control group. The apolipoproteins do not show any relationship to the degree of severity of the coronary sclerosis. By means of the parameters combination (Apo A + TC/alpha-C) with a diagnostic sensitiveness of 0.83 and a specificity of 0.87 a coordination coronary disease--healthy could be performed. The classification according to risks should then be performed by means of a cholesterol quotient (TC/alpha-C or TC/HDLC).

Apolipoproteins↗
PubMed1986

Placental and circulating pregnancy-associated plasma protein A concentrates in normal and pathological term pregnancies.

The relationship between placental and peripheral concentrations of pregnancy-associated plasma protein A (PAPP-A) was investigated, using specific radioimmunoassay techniques. At term, placental concentrations of PAPP-A were significantly lower in diabetic pregnancies; 1.9 +/- 0.2 micrograms/mg (mean +/- SE) placental protein as compared with controls (3.2 +/- 0.3). Similar findings were noted when results were analyzed per total placental weight. Patients with classes C-R (1.2 +/- 0.3) had significantly lower PAPP-A levels than in classes A, B (2.4 +/- 0.3 micrograms/mg protein, P = .02). Peripheral PAPP-A levels were measured in patients with chronic hypertension, toxemia, diabetes mellitus, and healthy controls. Overall, the distribution of PAPP-A values in patients with diabetes mellitus were different from controls. In addition, concentrations of PAPP-A in patients with classes B-D were significantly lower than in class A (P less than .001). In patients with chronic hypertension, some values of PAPP-A were lower than the tenth percentile, while patients with toxemia had a distribution which was similar to that of controls.

Diabetes Mellitus↗
PubMed1985

[The lipoprotein profile of hypertensive patients and its modification by 4 weeks of physical training during spa treatment].

Investigations of the lipoprotein spectre on 47 male patients with hypertension (mean 49.6 years) achieved a higher proportion of vasoaggressive lipoproteins than in 26 male healthy controls. With the exception of the genetically determined and familial forms respectively, we class the hyperlipoproteinaemia and the dyslipoproteinaemia with the acquired metabolic influences for the manifestation and the further development of a hypertension. By general aerobic perseverance training the hypertension as well as the hyperlipoproteinaemia can be positively influenced.

Combined Modality Therapy↗
PubMed1985

[Specificity and sensitivity of lipoprotein lipids in normal persons and cardiovascular patients].

The amplitude of the determination of lipoprotein lipids and cholesterol quotients for the estimation of the atherogenic risk and the risk of myocardial infarction was investigated on 24 normal persons, 21 patients with overcome myocardial infarction, 47 hypertensives and 20 obese patients. Under the methodical conditions the quotient total cholesterol/HDL cholesterol showed the best separating power between normal and atherogenically endangered (increased risk greater than 6.0: specifity 92%, sensitivity 67% for patients with infarction, 57% for hypertensives, and 45% for obese persons). LDL-cholesterol, calculatorily established by means of Friedewald's formula, and the quotient LDL/HDL-cholesterol with circa the same specifity for the groups of patients had a clearly lower sensitivity (patients with infarction 38%, hypertensives 50%, obese 21%). The lower sensitivity of the quotient LDL-/HDL-cholesterol is traced back to methodical insufficiencies (calculation of the LDL-cholesterol from three lipid values). The determination of the quotient total cholesterol/HDL-cholesterol for the description of the atherogenic and coronary risk respectively, is recommended for practice.

Adult↗
PubMed1985

Matrix compartments in the growth plate of the proximal tibia of rats.

The cartilaginous matrix in the growth plate of the proximal tibia of rats is subdivided into various compartments according to criteria established by electron microscopic examination. In conventionally fixed specimens, the arrangement of collagen fibrils was analyzed by transmission and scanning electron microscopy. Distribution of proteoglycans and relations between matrix and cells were studied after fixation in media containing cationic dyes. Matrix compartments are best characterized by the density and arrangement of their collagen fibrils. On the other hand, proteoglycans are distributed almost homogenously all over the matrix. Each chondrocyte is surrounded by a thin envelope of proteoglycans, the pericellular matrix. Adjacent to this is a layer dominated by the content and order of its collagen fibrils, the territorial matrix. Its inner part covers the pericellular matrix with a thin net of intersecting fibrils. The outer part unites the cells of each column by a sheath of tightly packed longitudinal fibrils. This distinction is only possible in the longitudinal parts of the territorial matrix, whereas in the transverse septa both layers fuse into a common network. The interterritorial matrix is interposed between the columnar units and thus represents the central part of the longitudinal septa. Mineralization is restricted to the interterritorial matrix and matrix vesicles are coincidentally found in the same compartment. During growth, this structural organization undergoes a permanent and relatively fast remodeling, a process that is discussed in view of possible cell matrix interactions.

Animals↗
PubMed1984

[Is cholesterol lowering following UVA blood irradiation an effect of citrate?].

On 92 patients the effect of the UV irradiation of blood on the blood parameters is studied. In the blood picture a decrease of leucocytes and reticulocytes is observed, in which case the latter is in connection with the decrease of blood and not with the UVA irradiation. In test persons with increased cholesterol level after UVA therapy as well as after a mere citrate infusion (anticoagulancy) during four weeks highly significant decrease of the cholesterol level, above all of the LDL-cholesterol appears. HDL cholesterol and triglycerides are not influenced. The decrease of cholesterol by citrate infusion is discussed and it is referred to possible therapeutic consequences.

Angina Pectoris↗
PubMed1984

[Direct quantitative determination of LDL cholesterol and HDL cholesterol using agarose gel electrophoresis].

The direct and quantitative determination of the main classes of the serum lipoproteins by means of a simple and reliable method is an urgent necessity for answering the numerous clinical questions. By precipitation of polyanions of the lipoproteins after electrophoretic separation in the agarosegel it is possible to determine sufficiently exactly and reproducibly their concentration without ultracentrifugation. For HDL- and LDL-cholesterol (beta-und alpha-lipoprotein cholesterol) a serial precision of 3 and 4%, respectively, and day,/day of 4 and 6%, respectively, was found. The methodology is described in detail and the problems of the establishment of the reference curves are particularly entered. In addition to this the determination of LDL- and HDL-cholesterol and beta- and alpha-lipoprotein cholesterol, respectively, was performed in sera of patients according to 3 and 4 variants, respectively, and these results were correlated with the densitometer surfaces of the beta- and alpha-lipoproteins. The correlation coefficients were between 0.94 and 0.99.

Arteriosclerosis↗
PubMed1984

[Change in the concentration of lipoprotein parameters following swimming training in health resort patients].

On 197 patients who were admitted to a sanatorium for the purpose of a heart and circulation cure the influence of a daily swimming training, 20-30 minutes 6 times a week with intensities of about 50-60% VO2 max, on the lipid and lipoprotein spectre, respectively was investigated. In the whole group of patients HDL-cholesterol (HDL-C) did not change. In patients with increased risk n = 40 (initial HDL-C: lower than 0.91 mmol/l) HDL-C significantly increased in the course of the cure. In group I n = 157 (without increase of HDL-C) as well as in group II n = 40 (with increase of HDL-C) LDL-cholesterol significantly decreased. The lipid index after Klimov and the quotient LDL-C/HDL-C decreased at the end of the treatment and they showed the most distinct change in group II. The separation of the lipoproteins by disc electrophoresis and the establishment of their percental distribution resulted in a decrease of the beta-lipoproteins and an increase of the alpha-lipoproteins for the two groups (I and II). The quotient beta-lipoprotein/alpha-lipoprotein also significantly decreased in the two groups. For the apolipoproteins A and B in group II no statistically ascertained changes of concentration were established. At the end of the treatment in group I apolipoprotein B highly significantly decreased, while apolipoprotein A did not change. In accordance with the cholesterol index also the reduction of the apolipoprotein index apo B/A was significant.(ABSTRACT TRUNCATED AT 250 WORDS)

Apolipoproteins↗
PubMed1984

RU 486: a steroid with antiglucocorticosteroid activity that only disinhibits the human pituitary-adrenal system at a specific time of day.

RU 486 is a synthetic steroid hormone antagonist which acts at the receptor level. It has both intrinsic anti-progesterone and antiglucocorticosteroid properties in animals. We investigated the antiglucocorticosteroid activity in humans by evaluating the pituitary-adrenal response to RU 486 in men and in pregnant and nonpregnant women. In non-pregnant women, RU 486 (approximately equal to 1 mg/kg of body weight per day) produced an interruption of the luteal phase without affecting the pituitary-adrenal axis, thereby indicating a more potent anti-progesterone than antiglucorticosteroid effect. In the course of pregnancy interruption by RU 486 (approximately equal to 4 mg/kg per day), there was a significant increase in plasma corticotropin, beta-lipotropin, and cortisol concentrations. In normal men, RU 486 administration led to a dose-dependent stimulation of plasma corticotropin, beta-endorphin, and cortisol. This disinhibition of the pituitary-adrenal axis was only observed during the morning hours of the circadian rhythm. When administered concomitantly with 1 mg of dexamethasone at midnight, 6 mg of RU 486 per kg completely suppressed the dexamethasone inhibitory effect on the pituitary-adrenal axis. These results indicate that RU 486 is an antiglucocorticosteroid that disrupts the negative pituitary feedback of both the morning cortisol rise and administered dexamethasone. Furthermore, they demonstrate the possibility of optimizing the anti-progestational effect of the compound and its potential use for human fertility control by modifying the dose and the time of administration of the drug and thereby minimizing the antiglucocorticosteroid effect.

Abortifacient Agents, Steroidal↗
PubMed1984

Cartilage ultrastructure after high pressure freezing, freeze substitution, and low temperature embedding. I. Chondrocyte ultrastructure--implications for the theories of mineralization and vascular invasion.

Electron microscopic examination of epiphyseal cartilage tissue processed by high pressure freezing, freeze substitution, and low temperature embedding revealed a substantial improvement in the preservation quality of intracellular organelles by comparison with the results obtained under conventional chemical fixation conditions. Furthermore, all cells throughout the epiphyseal plate, including the terminal chondrocyte adjacent to the region of vascular invasion, were found to be structurally integral. A zone of degenerating cells consistently observed in cartilage tissue processed under conventional chemical fixation conditions was not apparent. Hence, it would appear that cell destruction in this region occurs during chemical processing and is not a feature of cartilage tissue in the native state. Since these cells are situated in a region where tissue calcification is taking place, the implication is that the onset and progression of cartilage calcification are, at least partially, controlled by the chondrocytes themselves. The observation that the terminal cell adjacent to the zone of vascular invasion is viable has important implications in relation to the theory of vascular invasion. This may now require reconceptualization to accommodate the possibility that active cell destruction may be a precondition for vascular invasion.

Animals↗