Biomedical subjects
Publications and source records attributed to W Hesse.
In the knee joints of 195 animals autologous, stored and fresh homologous osteochondral grafts were implanted. Even after 2 years the ultrastructural examination indicates that autologous and fresh homologous grafts survive. The stored grafts are absorbed. The clinical results after transplantation of 38 patients as well as the technique of transplantation are demonstrated.
Our experimental work was concerned with the healing process of fresh homologous osteochondral grafts in the knee joints of 45 sheep. The ultrastructural investigations pointed clearly to the fact that the cells of fresh homografts completely survive under optimal conditions. Neither transformation nor metaplasia were evident.
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The authors' experimental work is concerned with the structure of articular cartilage after transplantation. In the medial condylus of the femur of the rabbit, bone-cartilage defects were produced and filled with bone-cartilage autografts and homografts preserved by different methods. At 2, 4, 6, 12, and 24 months after operation animals were sacrificed. The first phase of the healing process shows regressive processes. The second phase is marked by reactions of repair. The results of the experiment indicate that transplantation of cartilage can be regarded as a possibility of therapy in order to heal bone-cartilage lesions.
First experience with xerography of the cruciate ligaments and their lesions in compared with the usual radiographic techniques. Both cruciate ligaments can be shown more often and with sharper contours by using double contrast-arthrography in xeroradiograms. The specific pictorial characteristics of xeroradiography are discussed.
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Morphologic alterations in liver cells after bile duct ligation are well known and documented in numerous reports. Biochemical studies concerning metabolic changes in cholestatic liver are rare. Therefore, in this study, liver cell metabolites and the capacity of the perfused cholestatic rat liver to produce glucose, urea and ketone bodies were measured. In addition the influence of dihydroxy bile acids on normal and bile duct ligated rat livers was studied. Concentrations of adenine nucleotides, lactate, pyruvate, 3-hydroxybutyrate, acetoacetate, glucose and UDP-glucose were found to be identical in cholestatic and normal livers. Glycogen content, however, was significantly lowered in cholestatic livers. Gluconeogenesis from lactate and urea production from ammonium chloride were only slightly reduced in bile duct obstructed rat livers. Dihydroxy bile acids did not affect the metabolism of normal or cholestatic livers. Ketone body production from oleate was reduced to 66% in bile duct obstructed livers, taurochenodeoxycholate further reduced this value to the normal value. In contrast to earlier reports (Fisher and co-workers, 1971 Lab. Invest. 21; 88-91; Gastroenterology 60: 742) chenodeoxycholate induced neither cholestasis nor a marked fall in ATP content or rat liver in our experiments with female Wistar rats. In conclusion, dihydroxy bile salts did exert toxic short term effects on rat livers.
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