Biomedical subjects

W Hills

Publications and source records attributed to W Hills.

2 recordsLinked to original sources

PubMed1982

Cooling: a new approach to bladder denervation.

Cooling tissues to temperatures close to zero preferentially destroys nerve. In vivo intracavity cooling of the urinary bladder of rabbits to temperatures between 0 degrees and 5 degrees C produced partial denervation of intramural nerves, assessed by silver staining techniques. All other tissues appeared normal histologically. Detrusor muscle function, assessed in vivo by cystometry and in vitro pharmacologically, was unaffected by this procedure, but 11 out of 18 rabbits showed long-term large increases in conscious bladder capacity following cooling.

Animals↗

PubMed1979

Intravesical lignocaine and detrusor instability.

The effect of intravesical lignocaine solution on detrusor instability of mixed aetiology was examined in 20 patients; 40 ml of 1% lignocaine solution with 40 ml of 8.4% sodium bicarbonate solution was instilled into the bladder. This produced increased bladder capacity in 19, altered bladder sensation in 9, changed the character of the cystometrogram in 9, and lowered the maximum detrusor pressure during bladder filling in 16. The symptomatic effect of lignocaine was short-lived in all but one patient in whom it lasted 24 h. The possible mechanism of this inhibitory effect on bladder function is discussed.

Adolescent↗