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Biomedical subjects

W Horton

Publications and source records attributed to W Horton.

32 records · Page 2Linked to original sources
PubMed1985

A procedure for the investigation of anesthetic/surgical deaths.

A procedure for the investigation of surgical/anesthetic deaths is presented which allows for clearly defined jurisdictional assessment and correlates the autopsy and toxicological findings with the pathophysiology of the anesthetic/surgical event. This procedure facilitates an accurate certification of the cause of death in patients who die during surgery and anesthesia.

Anesthesia, General↗
PubMed1981

Diastrophic dysplasia: the death of a variant.

Diastrophic dysplasia is a distinct autosomal recessive disorder originally described in 1960. Since that time, a number of patients with similar but less severe involvement have been diagnosed as having a "diastrophic variant" disorder. This study reviews the radiological features of classic diastrophic dysplasia and compares them with the radiological findings in 26 patients with the diastrophic variant disorder. It is concluded that there is a wide variability in the phenotypic expression of diastrophic dysplasia even within sibships, and that cases of diastrophic variant disorder are actually mild forms of diastrophic dysplasia.

Adolescent↗
PubMed1981

The variable manifestations of extraarticular synovial chondromatosis.

Clinically, patients with extraarticular synovial chondromatosis are seen with a juxtaarticular mass due to metaplasia of synovial cells and subsequent formation of cartilaginous nodules. Three patients are described to illustrate the varied clinical and radiographic features of this disease. One patient had involvement of the knee and wrist while another had involvement of the knee along with presumed intraarticular synovial chondromatosis of the elbow. The third patient had a solitary finger lesion. Routine radiographs in extraarticular synovial chondromatosis demonstrate either solitary or multiple calcified juxtaarticular masses with chondroid matrix. Bone scintigraphy reveals intense radionuclide uptake within the calcified masses. Computed tomography clearly defines the extent of the lesion. Arthrography can evaluate for intraarticular extension.

Adolescent↗
PubMed1979

Developmental trends in eating rates of normal and overweight preschool children.

Eating rates (bites per interval) and other meal behaviors (number of chews, sips, talks with a neighbor, and chews per bite) were observed for 30 normal and 30 overweight white preschool children in their school cafeterias. Children were classified according to weight (overweight or normal), age (1 1/2--2 years, 3--4 years, or 5--6 years) and sex. Analysis of variance revealed that overweight preschool children demonstrated a somewhat higher rate of distinctly fewer chews per bite. Boys showed increasing chew rates with increasing age. Talk rates also increased with age but were unrelated to sex or weight status. Sip rates were not significantly associated with age, sex, or weight status. These results support the hypothesis that overweight persons are characterized by an increased eating rate and show that it is apparent even around the time of first self-feeding.

Age Factors↗
PubMed1975

Indwelling pulmonary artery catheters. Their relationship to aspetic thrombotic endocardial vegetations.

To assess the incidence of aseptic thrombotic endocardial vegetations (TEV) after pulmonary artery catheterization with Swan-Ganz catheters we reviewed all autopsy reports for a two-year period in our hospital. In 413 autopsies there were five instances of aseptic TEV: 3 in 88 patients with Swan-Ganz catheters, 1 in 120 patients with central venous catheters, and 1 in the 205 patients without central vascular catheters. The incidence of TEV is significantly greater in patients with Swan-Ganz catheters than in other patients.

Adult↗
PubMedDate not supplied

Expression and structure of cartilage proteins.

Cartilage has unique physical characteristics attributable to the presence of an unusually high content of proteoglycan embedded in the network of collagen fibrils. Advances in understanding the structure of these components and how their synthesis is regulated have been greatly assisted by the application of molecular biology. For example, an immortalized rat chondrocyte cell line was obtained by infection with a recombinant retrovirus encoding the myc gene product. Several positive and negative DNA regulatory elements of the collagen II gene have been identified that appear to be important in the regulation of this gene in chondrocytes. The complete primary structure of the cartilage proteoglycan (aggrecan) core protein deduced from cDNA sequence displays a complex multidomain structure including numerous repeats of Ser-Gly sequences and sequence homologies with link protein and animal lectins. Such studies advance our understanding of normal morphogenetic events and lay the groundwork for determining the basis of molecular and genetic defects.

Animals↗