[Clinically primarily generalized grand mal seizures].
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Biomedical subjects
Publications and source records attributed to W Horyd.
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The purpose of this study was establishing the effect of moderate exercise on EEG tracings in young epileptics. The model of graded exercise was 15-minute work on a cycle ergometer. The effect of the exercise on the pattern of simultaneously recorded EEG was compared with the effect of 3-minute hyperventilation. After testing a control group of 20 young subjects without evidence of organic brain damage or with this damage causing no epilepsy another group of 43 epileptics was studied. In none of these patients the intensity of changes in EEG increased during the exercise but evident EEG differences could be detected during different stages of the exercise in 28 patients with significant generalized discharges. It was found that during the exercise in nearly all patients the number of discharges decreased while during hyperventilation it increased. In 10 patients in this group a repeated rise in the number of discharges was observed immediately after the exercise which was connected usually with greater fatigue after the exercise. In the light of these results the authors conclude that moderate exercise inhibits rather seizure activity in EEG contrary to hyperventilation which increases these changes.
In the years 1976-1979 all cases of first epileptic seizure of any type were analysed in the whole population of the Mokotów District. The total number of patients with the first seizure in life was 272. The mean annual incidence coefficients were: for the repeatedly occurring seizures (i.e.epilepsy)--21.2/100 thousand of the general population, including 25.3 for men and 17.5% for women; isolated seizures--8.0 and 10.1 and 6.1 respectively; febrile seizures (diagnosed in children aged up to 4 years)--12.9 and 15.6 and 10.4 respectively; in another 2.3 subjects per 100 thousand the reported seizures were suspected of being epilepsy. It may be stated, generally, that in each 100 thousand of the population 44 subjects require annually examination because of epileptic seizure of seizures (or a disease in which seizures were one of its signs). The incidence was higher in men than in women (54 and 36 respectively). Epilepsy incidence coefficients and similar coefficients of isolated seizures were low in the first two decades of life, rising then gradually to a maximal level at the age of 70 and more years (60,3/100 thousand). The aetiology of the disease was disclosed in 70% of cases: head trauma in 20%, chronic alcoholism in 16%, stroke in 12%, brain tumour in about 10%. These were the most frequent aetiological factors. During follow-up 31 patients died, mostly the cases of brain tumour (40%), stroke (29%) and intracranial haematomas (about 10%). EEG obtained shortly after the first seizure is of low prognostic value.
The authors studied 30 cases of subacute sclerosing panencephalitis in various stages of the disease. The group comprised 28 children with a mean age of 7.8 years and 2 adults ages 22.5 years on the average, who were in remission. Apart from characteristic EEG findings with rhythmic seizure activity typical of this disease, in several cases other patterns were observed connected with the phase of the disease: in phase II with changes resembling hypsarrhythmia, in phase III generalized slowing down of the rhythm without discharges. Gradual disappearance of discharges with progression of the disease was observed. The authors discuss the possible pathological mechanism of EEG changes and their evolution.
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The purpose of the study was to establish the frequency of EEG abnormalities in mother and child when one of them has epilepsy. The incidence and type of EEG abnormalities were analysed in 2 groups: 33 epileptic children and their 31 healthy mothers, and 28 epileptic mothers with their 46 clinically healthy children. For illustration of data distribution in EEG the examined subjects were divided in both groups into mother-child pairs comparing the features of the records as well as morphological similarity of the curves in mother and child. It was found that the probability of abnormalities in the bioelectric activity of the brain is the same in a healthy child of an epileptic mother (67.3%) as in a healthy mother of an epilepitic child (51.6%). The frequency of EEG pathology was greater in daughters than in sons of epileptic mothers. Similarities in morphological patterns of EEG occurred in only 3 cases in mothers of epileptic children and in 8 children of epileptic mothers.