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Biomedical subjects

W Hunter

Publications and source records attributed to W Hunter.

At least 19 recordsLinked to original sources
PubMed1996

Expression of p53 in conjunctival melanocytic nevi. An immunohistochemical study.

The objective of this study was to evaluate conjunctival nevi for p53 gene mutations. We studied 11 conjunctival nevi by immunohistochemistry with the DO7 monoclonal p53 antibody as well as the cell proliferation marker, MIB1. Of the 11 cases, 2 were negative, 2 had less than 1%, and 7 had more than 2% p53 immunopositive nuclei with no direct correlation with MIB1 positivity. Our results suggest altered expression of p53 in conjunctival nevi.

Antibodies, Monoclonal↗
PubMed1993

Malignant acanthosis nigricans. A case report.

PURPOSE: The authors present a case of malignant acanthosis nigricans that has two unusual aspects. The first is involvement of the lid margins with confluent papillomata, causing severe visual impairment, and the second is the association with lung malignancy. METHODS: A 65-year-old Portuguese man presented with decreased vision, papillomatous lid lesions, pruritus, and progressive thickening of the skin of his face, neck, axillae, and inguinal creases. A diagnosis of acanthosis nigricans was made after skin biopsy. Systemic investigations showed a suprahilar mass, and biopsy was positive for squamous cell carcinoma of the lung. RESULTS: The patient underwent excision of papillomata from all four lid margins, and this was repeated 1 year later. He also completed a course of palliative radiotherapy. CONCLUSION: Malignant acanthosis nigricans is rarely associated with lung neoplasms, being more commonly a manifestation of intra-abdominal malignancies. Of note in this case is the extensive ocular involvement and visual impairment.

Acanthosis Nigricans↗
PubMed1991

The effect of self-administered faecal occult blood tests on compliance with screening for colorectal cancer: results of a survey of those invited.

To determine the relative importance of health beliefs and the characteristics of different methods of faecal occult blood screening in predicting acceptance of the test a self completed questionnaire was offered to 590 patients registered with a practice in an Oxfordshire market town. The patients were an age-sex stratified random sample of those who had been offered screening as part of a trial in which one of three different faecal occult blood screening tests, two of which were self-reported, had been offered. The overall adjusted response rate was 70.1%. Those who complied with the test had more positive attitudes to the implications of a positive test, to treatment and to the value of screening in general. The experience of a close relative or friend with bowel cancer was associated with an increased likelihood of compliance [odds ratio = 15.2 (9.4-24.3)]. Three were marked differences between the tests in the proportions of patients finding them 'messy' or 'disgusting' (Haemoccult 72.0%, Coloscreen 48.0%, Early Detector 55.4% chi 2 Haemoccult vs. self-reported = 5.05 P less than 0.05), and the odds of finding the procedure disgusting were significantly higher among patients who did not complete the test [odds ratio 6.9 (3.1-15.5)].

Attitude to Health↗
PubMed1989

The effect of halothane, enflurane, and isoflurane on the dynamic stiffness of rabbit papillary muscle.

The authors examined the effect of halothane, enflurane, and isoflurane on the dynamic stiffness of rabbit papillary muscles in Ba2+ contracture. Ca2+ was replaced by Ba2+ in order to constantly activate myofibrils. The dynamic stiffness of the contractured muscle was examined by exposing the muscle to sinusoidal length perturbations at frequencies of 0.05-30 Hz under two concentrations of anesthetic, approximately 0.5, and 1.5-2 mM, and at two Ba2+ concentrations, 0.5 and 1.5-2 mM. The anesthetics had no effect on the frequency (fmin) at which minimum stiffness occurred, but markedly decreased the stiffness modulus at high frequencies (Khi). The decrease in Khi was significant for all anesthetics at the P less than 0.05 level. Increasing the Ba2+ concentration from 0.5 to 1.5-2 mM in the presence of 0.5 mM of anesthetic resulted in a return of Khi to control levels. The authors conclude that halothane, enflurane, and isoflurane did not alter actin-myosin ATPase kinetics, because fmin was unchanged, but decreased the number of crossbridge interactions, because Khi was significantly decreased by all three anesthetics.

Animals↗
PubMed1989

Some determinants of fear about AIDS among Australian college students.

An 18-item questionnaire assessing attitudes toward AIDS and homosexuality was administered to 420 Australian tertiary students. The predictive power of attitudes toward homosexuality, empathy toward AIDS sufferers, knowledge about AIDS, church attendance, age, and sex was tested using independent and stepwise multiple-regression analyses. In the stepwise analysis attitudes toward homosexuality and empathy toward AIDS sufferers were the major contributors to fear about AIDS. Church attendance and age improved the over-all prediction significantly, but only slightly. In the independent analysis all variables, except church attendance, were significant predictors. Educational programmes on AIDS should address the relationship between homosexuality and fear of AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1989

Infectious crystalline keratopathy.

Infectious crystalline keratopathy was first described in 1983. affected corneal grafts generally show progressive scarring and often require penetrating keratoplasty. We present a patient in whom infectious crystalline keratopathy developed 3 months after surgery. The infection was successfully treated with antibiotic therapy.

Aged↗
PubMed1988

From inquiry to judgment: age and sex differences in patterns of adult moral thinking and information-seeking.

This research examined age and sex variations in moral judgment processes across the life-span, primarily using objective questionnaire techniques. Both stage level of judgment and patterns of requests for further information following dilemma presentation were studied in 242 respondents, ages fourteen to ninety-two, in order to measure individual differences in judgment orientations hypothesized by Gilligan and suggested by theorists of aging. There were few indications of sex differences in either stage or patterns of information-seeking, except for a generally greater preference for additional information in decision-making by women. With respect to age trends, participants over age seventy-five scored at significantly lower stage levels than younger adult groups. However, elderly adults' judgments did not appear simply "regressed" to earlier developmental levels. On both objective and open-ended measures, older participants seemed more likely than younger groups to assimilate moral dilemma information to their own general cognitive frameworks, consistent with an hypothesis of greater synthesis in judgment among the elderly.

Adolescent↗
PubMed1983

Private medical insurance in New Zealand: issues of membership and growth.

Questions concerning ownership of private medical insurance were included in a recent Department of Statistics' survey of a random sample of almost 7000 New Zealanders. The results indicated that 35% of those surveyed owned private medical insurance and such ownership was significantly related to various social, demographic and health related variables. The findings are discussed in terms of the possibilities for growth of private medical insurance and the implications of such growth for both the public and the private health care sectors.

Adolescent↗
PubMed1979

Two cases of trisomy 12p due to rcpt (12;21)(p11;p11) inherited through three generations.

Two cases of trisomy 12p due to a familial translocation t(12;21) (p11;p11) inherited through three generations are presented. The clinical features of both affected individuals are consistent with those previously reported. Study of the NORs by silver staining showed translocation of the NOR from chromosome 21 onto the der(12) and suggested that the activity of this site has been suppressed in some carriers.

Adolescent↗
PubMed1976

Can impedance characterize the heart?

When considering the use of Fourier series in hemodynamics, the question is whether one can relate the frequency components of the flow oscillations to the corresponding ones of pressure using impedance concepts. For the arteries, this method provided the basis for great advances in understanding. However, it is precisely because the arterial tree acts almost linearly while its properties do not change markedly within one beat that frequency analysis achieved such success. For the ventricle, in which the mechanical properties vary widely over the course of one heart cycle, Fourier analysis loses its usefulness. Consequently, we must return to the time domain for formulating a description of the heart as a pump. A time-domain method, the impulse response, is suggested as a possible alternative to impedance.

Compliance↗