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W I Cottel

Publications and source records attributed to W I Cottel.

17 recordsLinked to original sources
PubMed1994

Squamous cell carcinoma of skin with perineural invasion.

BACKGROUND: Perineural invasion of squamous cell carcinoma of the skin causes increased mortality. OBJECTIVE: We compared survival rates for treatment with Mohs surgery with previous studies of conventional surgery and postoperative radiotherapy. METHODS: With a computerized tumor registry we identified 44 cases of squamous cell carcinoma with perineural invasion recurrence, and hazard rates were calculated. RESULTS: Of 44 patients treated with Mohs surgery, three had recurrences. On this basis a survival probability of 88.7% was calculated. Calculation of hazard rate showed highest probability of recurrence 3 to 6 years after Mohs surgery. The clinical characteristics associated with perineural tumor invasion were male sex, size of tumor (> 2 cm), forehead location, and previous therapy. CONCLUSION: When compared with conventional surgical excision and postoperative radiotherapy, early detection and treatment by Mohs surgery of squamous cell carcinoma with perineural invasion result in a much improved survival probability.

Aged↗
PubMed1988

Treatment of extensive extramammary Paget disease of male genitalia with Mohs micrographic surgery.

It is often difficult to accurately judge the clinical tumor margins for extramammary Paget disease. Mohs micrographic surgery was used to extirpate a tumor which clinically measured 159.5 cm2. Following Mohs micrographic surgery, it was found that the actual dimensions of the tumor had been underestimated by 97 per cent. Since the Mohs micrographic surgeon microscopically examines the entire subcutaneous margin of the resected tumor, this technique provides an accurate method of determining the depth of tumor penetration. Mohs micrographic surgery allows for maximal conservation of normal tissue and yields higher cure rates than other conventional methods of treatment. When approaching tumors of the genitalia which may display poorly defined clinical margins, Mohs micrographic surgery should be considered the technique of choice.

Aged↗
PubMed1987

Multifocal recurrent basal cell carcinoma following primary tumor treatment by electrodesiccation and curettage.

Eight recurrent basal cell carcinomas and their adjacent scars, which were previously treated with electrodesiccation and curettage, were completely excised by Mohs micrographic surgery and then studied by serial vertical sections. Through the study of an average of 291 serial sections of each recurrent tumor, it was found that four of eight recurrent basal cell carcinomas contained multiple foci of unconnected tumor. It is concluded that iatrogenic multifocality of recurrent basal cell carcinoma previously treated with electrodesiccation and curettage is common. Complete excision of the recurrent basal cell carcinoma and its adjacent scar is supported in view of the high risk of multiple unconnected tumor foci.

Adult↗
PubMed1982

Mohs' surgery, fresh-tissue technique. Our technique with a review.

A modified method of the fresh-tissue technique of Mohs' surgery is presented with a discussion of its developmental background and advantages. The refinements obviate the need for the chemical fixative. We therefore advocate acceptance of this technique in all cases of cutaneous carcinomas requiring Mohs' surgery.

Basal Cell Carcinoma↗
PubMed1982

Perineural invasion by squamous-cell carcinoma.

Perineural invasion by squamous-cell carcinoma is an ominous sign when discovered by either the pathologist or the chemosurgeon. This report details our experience with seventeen cases of perineural invasion and their successful outcome, using a multidisciplinary approach, including Mohs' surgery.

Aged↗
PubMed1982

Metastatic basal-cell carcinoma.

Three cases of metastatic basal-cell carcinoma are reported. All of the cases were relatively small when compared with other lesions reported in the literature. With early chemosurgical treatment of small recurrent carcinomas, metastasizing basal-cell carcinoma will be a condition of the past.

Aged↗