Biomedical subjects
W I Rogers
Publications and source records attributed to W I Rogers.
The physiological disposition of 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia.
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Effect of allopurinol on the pharmacokinetics of 6-mercaptopurine (NSC 755) in cancer patients.
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Determination of labile trifluoromethyl compounds with a fluoride--ion electrode: differential analysis of 5-trifluoromethyluracil and 5-trifluoromethyl-2'-deoxyuridine.
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Enhancement of 6-thioinosine-5'-monophosphate synthesis in solid L1210 lymphocytic leukemia cells by prior exposure to 6-mercaptopurine.
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The fate of 5-trifluoromethyl-2'-deoxyuridine in monkeys, dogs, mice, and tumor-bearing mice.
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Physiologic disposition of 1,3-butanediol cyclic sulfite (NSC-60195) given orally to rats.
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Studies on the intracellular localization and effects of 2-chloro-4',+"-di(2-imidazolin-2-yl)terephthalanilide on mitochondria from P388 lymphocytic leukemia and rat liver.
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Equivalence of oligomycin and 2-chloro-4',4"-di(2-imidazolin-2-yl)terephthalanilide in their effects on mitochondrial swelling.
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Relationship of uptake and binding of an antileukemic phthalanilide to its biochemical and chemotherapeutic effects on P388 lymphocytic leukemia cells.
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Studies of the effects of 4'4"-bis-(1,4,5,6-tetrahydro-2-pyrimidinyl)-terephthalanilide dihydrochloride on oxidative phosphorylation in mitochondria of rat kidney and liver.
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Physiologic disposition of 4',4''-bis(1,4,5,6-tetrahydro-2-pyrimidinyl)terephthalanilide and 4-(1,4,5,6-tetrahydro-2-pyrimidinyl)-4'-[p-(1,4,5,6-tetrahydro-2-pyrimidinyl)phenyl]carbamoylbenzanilide in dogs, monkeys, rats and mice.
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Relationship of phthalanilide-lipid complexes to uptake and retention of 2-chloro-4',4"-di(2-imidazolin-2-yl)terephthalanilide (NSC 60339) by sensitive and resistant P388 leukemia cells.
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Purification and characterization of phthalanilide--lipid complexes from tissues.
What appears to be a new class of phospholipids has been isolated from dog brain in the form of complexes with a substituted phthalanilide. The complexes were extracted by chloroform-methanol and purified by countercurrent distribution in solvent systems containing water, chloroform, methanol, and Freon 113. The binding of the phthalanilide congener to lipids has some ionic character. Cations such as H(+) or Ca(++) displaced the phthalanilide from its lipid complex. The pH for 50% displacement acid was about 3.8 and was independent of the purity of the complex. Thin-layer chromatography of the lipid yielded four subfractions of lipid, three of which were ninhydrin-positive and all of which yielded a group of unidentified ninhydrin-positive components on hydrolysis. Each lipid subfraction contained nitrogen, phosphorus, fatty acids, and glycerol but in different ratios. Of the known phospholipids containing nitrogen, none matches the composition and behavior of the lipids isolated as phthalanilide complexes. We have therefore concluded that the phthalanilides bind to a new class of phospholipids characterized by a high content of unidentified ninhydrin-positive components.
Toxicology of anti-leukemic agents with special reference to phthalanilide derivatives.
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Studies on the formation of phthalanilide-deoxyribonucleic acid complexes and their relationship to chemotherapeutic activity.
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