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Biomedical subjects

W Iwaszko-Krawczuk

Publications and source records attributed to W Iwaszko-Krawczuk.

At least 19 recordsLinked to original sources

Acoustic rhinometry assessment of the nasal cycle in neonates.

In this study the nasal cycle in newborns was assessed using acoustic rhinometry with miniprobe (RHIN 2100). Enrolled in the study were 67 newborns aged 2 to 4 days. Each subject was assessed for 3 h, examinations taking place every 30 min. At least six measurements, three from each nostril, were taken at each examination. The miniprobe RHIN 2100 (SR Electronics ApS) was used for evaluation of nasal geometry. The minimal cross-sectional area (MCA) and the total volume of the anterior 45 mm (VOL45) were calculated and used for statistical analysis. The mean volume of MCA and VOL45 in the examined group of children was 0.08 cm3 and 1.19 cm3 respectively. Nasal cycle was assessed by constructing the plots of acoustic rhinometry parameters MCA or VOL45 for time and statistically using Pearson's correlation coefficients. Most of the examined infants (70-85%) showed no significant fluctuations in nasal patency.

Airway Obstruction↗

[Evoked otoacoustic emissions in the neonatal hearing screening].

Early identification of hearing impairment in children is a major problem for clinical research and development. Transient click evoked otoacoustic emissions (TEOAE) have been shown to be a useful test of hearing impairment, especially when used for infant screening. The purpose of this study was evaluation of transiently evoked otoacoustic emissions (TEOAE) for the two-stage screening of infant hearing. The first stage was measurement of otoacoustic emissions. TEOAE were performed in 200 infants. 17.5% of the children exhibited risk factors for hearing impairment. Those failing the second stage proceeded to auditory brain-stem response (ABR). The absence of TEOAE in both ears in 2 children was detected by ABR. The data obtained show that two stage newborn hearing screening is practicable, effective, low-cost and safe.

Acoustic Stimulation↗

[Acid-base balance in hypotrophic neonates in the first hours of life].

Our purpose was to present parameters of acid-base status at 30, 90 and 150 minutes after delivery in cases of hypotrophic infants. Significantly lowered values of pH, HCO3 and BE were found as compared to results of normal term infants. Parameters are consistent with metabolic acidosis. Such conditions require appropriate treatment.

Acid-Base Equilibrium↗

[Concentration of C3 in sera of small for gestational age newborns in relation to sex and degree of hypotrophy].

36 small-for-date newborns both sexes with body weight below 10 percentiles were included to our studies. To control group we have enrolled 33 newborns in the same fetal age. We conducted the present study to address whether fetal hypotrophy induce or not decrease of the concentration of C3 in sera of these newborns. Despite of our expectations we have found there is increase C3 in sera in relation to the degree of hypotrophy. We have noted the concentration of C3 is not related to the sex both small-for-date newborns and newborns.

Complement C3↗

Bactericidal capacity of plasma and granulocytes against Escherichia coli in the small-for-dates newborn.

Infections due to Gram-negative bacteria in newborns and especially small-for-dates newborns sometimes run a dramatic course and have a high mortality rate. The bactericidal effect of plasma and granulocytes was determined by the method of Balch et al [1] in 27 small-for-dates term newborns and 19 normal term newborns. The number of killed bacteria was practically the same in th mixture of granulocytes and plasma in both groups. On the other hand, a threefold decrease of the bactericidal effect of plasma was observed when it was applied alone, without granulocytes. This may indicate that the defect is more in the plasma than in the granulocytes, and is probably due to the failure of class IgM antibodies to cross the placental barrier.

Blood Bactericidal Activity↗

[Comparison between haemostatic parameters of full - term and premature newborns (author's transl)].

Twenty-five full-term newborns were compared to 20 premature newborns for several haemostatic parameters. The latter group exhibited no clinical symptoms of respiratory distress syndrome, except for two cases. The coagulative system was activated in either group. Differences were clearly recordable from the fibrinolytic system and indicated activation of fibrinolysis in full-term newborns and relative insufficiency of the same system in premature newborns. The need for assessment of both the coagulative system and fibrinolysis in any case of premature delivery is suggested by the authors and considered necessary for diagnosis, prophylaxis, and possible therapy of respiratory distress syndrome. Activation of fibrinolysis is interpreted as a mechanism of defence against concomitant intravascular coagulation, while the absence of compensation in the fibrinolytic system of the newborn is considered to be a mechanism which might lead to hyaline membrane syndrome.

Blood Coagulation↗

Nitroblue tetrazolium test in the term small-for-dates newborn.

The value of the nitroblue tetrazolium reduction test was studied using granulocytes obtained from 41 small-for-dates and 23 normal term newborns. The unstimulated test did not show any differences between the two groups, while after latex stimulation a statistically significant decrease was noted in the reduction by granulocytes obtained from small-for-dates newborns in comparison to those obtained from normal newborn infants. The results showed a wide scattering especially in the small-for-dates newborns. This may indicate that in some of these babies the granulocytic enzymes are defective to reduce the nitroblue tetrazolium to purple formazan.

Blood Bactericidal Activity↗