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W J Bashe

Publications and source records attributed to W J Bashe.

4 recordsLinked to original sources
PubMed2000

Comparative methodology in the determination of alpha-oxocarboxylates in aqueous solution ion chromatography versus gas chromatography after oximation, extraction and esterification.

The alpha-oxocarboxylates (alpha-ketocarboxylates) and the corresponding alpha-oxoacids (alpha-ketoacids) have been reported as byproducts of ozonation of potable water supplies. Some of these species also occur in biophysiological systems. Five analytes were investigated in this study: oxoethanoate (glyoxylate), 2-oxopropanoate (pyruvate), 2-oxobutanoate (2-ketobutyrate), 2-oxopentanoate (2-ketovalerate) and oxopropanedioate (ketomalonate, mesoxalate). Ion chromatography (IC) and gas chromatography (GC) were evaluated for the quantitation of these analytes at concentrations < or =200 ng ml(-1). For the IC method, the samples are run directly with minimal to no pre-treatment. For the GC method, the analytes must be derivatized with O-(2,3,4,5,6-pentafluorobenzyl)oxylamine to form oximes. The oximes are extracted into tert-butyl methyl ether and the carboxylic acid is esterified (methylated) with diazomethane. It was concluded that the ion chromatographic determination is significantly superior to the gas chromatographic method for these analytes.

Carboxylic Acids↗
PubMed1975

Pathology of atherosclerotic heart disease in sudden death. I. Organizing thrombosis and acute coronary vessel lesions.

The significance of organizing thrombosis was investigated in 121 cases of sudden death with atherosclerotic heart disease. Organizing thrombosis was observed in one-third of the cases, and sites at which it was present showed a higher prevalence of acute lesions -- thrombus, plaque rupture, and hemorrhage -- than sites at which it was not present. Acute and subacute coronary lesions were almost entirely restricted to vessels with 75% or greater obstruction. Evidence was presented suggesting that the organization of thrombosis in the coronary arteries was a more extended process than that observed in peripheral arteries.

Autopsy↗
PubMed1975

Pathology of atherosclerotic heart disease in sudden death. II. The significance of myocardial infarction.

The role of myocardial infarction was investigated in 121 cases of sudden death with atherosclerotic heart disease. In addition to supporting other reports which have demonstrated the importance of chronic occlusion of the coronary vessels in relation to the high rate of infarctions found in such cases, the authors presented evidence which showed differences in occurrence in the sites of remote and recent infarctions, a lack of concordance between the sites of recent infarctions, and acute thrombosis in coronary vessels proximal to these lesions. No relationship between patient age or prior symptoms could be associated with the occurrence of infarction. Evidence was also presented which discounted the possible role of transmural infarction in the formation of acute thrombosis. These pathological observations support the concept that sudden cardiac deaths are results of functional instability of the myocardium produced by advanced coronary atherosclerosis.

Adolescent↗