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Biomedical subjects

W J Boonk

Publications and source records attributed to W J Boonk.

9 recordsLinked to original sources
PubMed1986

Pathogenetic studies in chronic urticaria. Failure to demonstrate vasculitis, complement activation and fibrinolysis.

To analyze the role of immune complexes, complement activation and fibrinolysis in chronic urticaria (CU), we performed serological, immunohistochemical and histopathological studies in 20 patients. In addition, the relationship to urticarial vasculitis was investigated. The results indicate that common CU is not associated with vasculitis. Neither circulating immune complexes nor immunoglobulin-complement complexes were found in the vessel walls. Lowered blood levels of complement and fibrinogen were found only in 1 and 3 patients, respectively. Alpha-2-antiplasmin and fibrin degradation products were within normal limits. Our study indicates that CU and urticarial vasculitis are separate entities. Complement activation and fibrinolysis do not appear to play an important role in CU.

Adolescent↗
PubMed1982

The role of penicillin in the pathogenesis of chronic urticaria.

Intracutaneous tests with penicilloyl-polylysine (PPL) and benzyl-penicillin G (PG) were performed in 245 patients suffering form chronic recurrent urticaria, including physical urticaria. Positive results were observed in fifty-nine patients (24%). Sera from fifty-seven of these fifty-nine patients were investigated for circulating anti-penicilloyl antibodies by an enzyme-linked immunosorbent assay (ELISA) and a passive haemagglutination test (HA). The results were compared to those form the ELISA and HA in a control group of thirty-five patients who had shown clinical allergic reactions to penicillin and had positive skin tests to PPL and/or PG. The in vitro tests revealed positive results in 12.3% and 37.1% respectively. In forty-three patients the course of the positive intracutaneous tests to penicillin, together with the duration of chronic urticaria, was followed over a period of time up to 3.5 years. In twenty-two out of forty-two patients with positive intracutaneous tests to penicillin, a diet free of dairy products proved to have a curative effect, compared to two out of forty control subjects with chronic urticaria and negative skin tests to penicillin. These studies indicate that penicillin has an important role in the aetiology and maintenance of chronic urticaria.

Animals↗
PubMed1982

Oral psoralen photochemotherapy of allergic contact dermatitis of the hands.

6 out of 9 patients with allergic contact dermatitis of the hands were successfully treated with oral methoxsalenultraviolet-A (PUVA) photochemotherapy. Clearing the dermatitis symptoms of the hands was achieved with an average of 23 treatments (150 J/cm2). To maintain the initial results a rather frequent maintenance treatment--usually once a week--was necessary. Longer treatment intervals resulted in a relapse of the dermatitis. This made continuous treatment necessary. In one patient treatment was stopped, and he remained clear for 17 weeks. The influence of PUVA on the allergic status of the patients is supposed to be a local effect. PUVA proves to be a valuable addition in the treatment of occupational hand dermatitis.

Adult↗
PubMed1981

Skin testing in chronic urticaria.

In 164 patients with chronic recurrent urticaria, the value of skin tests was investigated, Patch tests carried out with the standard series of the International Contact Dermatitis Research Group and with a series of penicillins revealed positive reactions in 22 (35/162) and 6.9% (11/158), respectively. IN 21.5% (33/152) positive intracutaneous tests to cilligen and/or penicillin G were observed. 35% (51!147) of the patients had one or more positive intracutaneous tests with inhalants. Scratch tests with food allergens showed positive reactions in 12.5% (12/95). There was no difference in results between patients with idiopathic urticaria or angio-oedema and those with physical urticaria. The value of these findings is discussed. Most of the patients with penicillin allergy, were recommended to be on a diet free from milk and milk products. In 50% this was successful.

Animals↗
PubMed1981

Dermatologic hazards from hidden contacts with penicillin.

The unbridled use of penicillin after its discovery by Fleming has resulted in possible hazards to human health due to traces of the drug being present in food and other hidden sources. These hazards may include toxic effects, hypersensitivity reactions and possibly a raising of the frequency and duration of allergy to penicillin.

Air Pollutants↗