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Biomedical subjects

W J FRAJOLA

Publications and source records attributed to W J FRAJOLA.

At least 19 recordsLinked to original sources

Molecular changes in deoxyribonucleic acid induced by X-rays.

A chromatographic study of molecular changes in DNA after in vitro exposure to x-rays revealed little effect on the DNA macromolecule when either intact red cells of frog or DNA isolated from these cells was exposed to 1000 r. Increasing the dose to 10,000 r resulted in a significant shift from gradients of lower molecular weight to the higher gradients. These data suggest that cross-linking of DNA occurred at the higher radiation level.

DNA↗

Carbonic anhydrase and the precipitation of apatite.

On theoretical grounds it is unlikely that the catalytic action of the enzyme carbonic anhydrase would be required for the precipitation of apatite in vitro. The presence of carbonic anhydrase in either active or inactivate form did not initiate precipitation in a metastable calcifying solution. It is unlikely that carbonate (or bicarbonate) ions are essential for the precipitation of apatite in vitro or in vivo.

Apatites↗