SERUM ENZYME CHANGES WITH OBSTRUCTIVE JAUNDICE AND HYPOTENSION.
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Biomedical subjects
Publications and source records attributed to W J FRAJOLA.
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A chromatographic study of molecular changes in DNA after in vitro exposure to x-rays revealed little effect on the DNA macromolecule when either intact red cells of frog or DNA isolated from these cells was exposed to 1000 r. Increasing the dose to 10,000 r resulted in a significant shift from gradients of lower molecular weight to the higher gradients. These data suggest that cross-linking of DNA occurred at the higher radiation level.
On theoretical grounds it is unlikely that the catalytic action of the enzyme carbonic anhydrase would be required for the precipitation of apatite in vitro. The presence of carbonic anhydrase in either active or inactivate form did not initiate precipitation in a metastable calcifying solution. It is unlikely that carbonate (or bicarbonate) ions are essential for the precipitation of apatite in vitro or in vivo.
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