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Biomedical subjects

W J Garrett

Publications and source records attributed to W J Garrett.

At least 19 recordsLinked to original sources

Thickness of tissues intervening between the transducer and fetus and models for fetal exposure calculations in transvaginal sonography.

In transvaginal scanning the tissues intervening between the fetus and transducer are relatively thin. The average thickness in the first trimester is 25 mm and reduces to 15 mm by the third trimester; the minimum thicknesses are 14 and 8 mm, respectively. Two models are proposed for calculating exposure in transvaginal scanning. The models are considered in terms of the overlying tissues and the target tissues. A fixed path, constant attenuation of 0.3 dB/MHz describes the properties of the overlying tissues throughout pregnancy. In the model used in first-trimester scanning, the target tissues of the embryo/fetus are considered to have properties similar to those of soft tissues, and they attenuate the energy at the same rate as the overlying tissues. In the model used in second- and third-trimester scanning, the bony structures of the fetus are the target tissues. These reflect 30% of the incident energy and attenuate all of the transmitted energy at their surface.

Extraembryonic Membranes↗

Early growth retardation in the first trimester: is it characteristic of the chromosomally abnormal fetus?

There have been recent reports on a small number of cases which suggest that the detection of early growth retardation might allow recognition of the chromosomally abnormal fetus in the first trimester of pregnancy. To amplify these observations, the crown-rump length (CRL) measurements between the 64th and 86th day of menstrual age were determined in (a) 500 control high risk patients in whom a normal karyotype was subsequently demonstrated by chorionic villus sampling (CVS) and (b) 25 chromosomally abnormal fetuses. The data indicate that early growth retardation, as expressed by a small CRL measurement, is not a special characteristic of the chromosomally abnormal fetus in the first trimester of pregnancy. The CRL measurement is therefore not a useful marker or screening test at that time, except perhaps for triploidy. The well documented growth retardation with trisomy 21 and trisomy 18 which has been observed in the second trimester does not begin until after the 12th week of menstrual age.

Adult↗

Chorionic villus sampling. Clinical experience in 50 diagnostic cases.

The results of 50 diagnostic chorionic villus samplings (CVS) are presented. In all but 2, the fetus was at risk of a chromosomal abnormality. Sampling was successful in 48 cases. One patient aborted 4 days after the procedure. Two patients had missed abortions diagnosed on ultrasound 44 and 56 days after CVS. Seven patients elected to have their pregnancies terminated. All samplings were undertaken with a specially designed cannula using realtime ultrasound guidance between 9 and 11 weeks of amenorrhoea. Endocervical swabs and blood for maternal serum alpha fetoprotein estimations before and after the procedure were routinely taken. All patients were notified of the results in 8 days or less except in 3 where long-term cultures were necessary. Six patients have delivered and 34 pregnancies are continuing satisfactorily.

Abortion, Missed↗

Fetal treatment 1982.

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Congenital Abnormalities↗

Fetal umbilical venous flow measured in utero by pulsed Doppler and B-mode ultrasound. I. Normal pregnancies.

Umbilical venous blood flow was measured with a pulsed Doppler unit, which was used in combination with a B-mode ultrasonic imaging system to permit location of the umbilical vein and measurement of its cross-sectional area. The accuracy and limitations of the method are discussed. Forty-seven normal fetuses with gestational ages ranging from 22 weeks to term were studied on a total of 61 occasions. Flow increased with gestational age until 36 weeks, was maximal between 37 and 38 weeks, then decreased during the last 2 weeks of pregnancy. Flow per unit of fetal weight was constant during pregnancy until 36 to 37 weeks, when a reduction occurred.

Blood Flow Velocity↗

Cerebral ventricular size in children: a two-dimensional ultrasonic study.

The width of the bodies of both lateral ventricles was studied in 833 children using B-mode echography. It could be accurately measured in 99.9% of those under the age of 2, 94% of these 2 to 5, and 65% of those 6 to 12. The normal lateral ventricular ratio or LVR (width of body of LV/0.5 X internal skull diameter) was 0.24-0.36, but there was a borderline area and the upper part of this range (0.34-0.36) included some cases of early hydrocephalus. In 72% of the children with a head circumference greater than the 98th percentile, the LVR was 0.24-0.36. The greatest transverse diameter of the atrium of the normal lateral ventricle in children appears to be 10 mm, that of the normal third ventricle 5 mm. A water-delay system is described as being superior to a contact system for B-mode echoencephalography.

Cerebral Ventricles↗

Cross sectional visualization of the normal heart by the UI Octoson.

The UI Octoson can provide accurate compound and simple scan cross sectional views of the heart. Sections taken in the transverse, sagittal, and other planes normal and parallel to the long axis of the heart are useful for providing full information that may be obtained by the examination. The views allow the visualization and measurement of most major structures of the heart, giving a more complete description of the geometry of the heart.

Echocardiography↗

The liquid-filled stomach--an ultrasonic window to the upper abdomen.

An ultrasonic window to the upper abdomen is creasted by (a) filling the fasting stomach with methylcellulose suspension, (b) administering glucagon intravenously, and (c) examining the patient prone. Glucagon relaxes the gastric musculature and the prone position allows the stomach gas to rise to the fundus. This enables assessment of the relationships of the stomach to adjacent structures and permits display of structures forming the stomach bed. The equipment used was a commercially available water-delay system with wide-aperture focused transducers. The system gives good resolution and allows the gastric musculature to be distinguished from the mucosa and its overlying mucus.

Abdomen↗

Ultrasonic echography in the diagnosis of abdominal disease.

The place of two-dimensional ultrasonic echography in the diagnosis of surgical diseases of the abdomen is outlined, and illustrative cases are described. The method is safe and can be repeated as often as required. It does not replace radiological or radionuclide examinations, but complements those techniques.

Abdominal Neoplasms↗