Biomedical subjects

W J Iliff

Publications and source records attributed to W J Iliff.

4 recordsLinked to original sources

PubMed1979

Orbital lymphangiomas.

The exact nature of lymphangiomas of the orbit is controversial. Nineteen cases with typical clinical, surgical, and histopathologic findings are presented. These tumors are diffuse, slowly progressive, difficult to remove, and relatively insensitive to irradiation. They frequently hemorrhage, causing rapid increase in proptosis, which may require emergency surgery, and they fluctuate in size with upper respiratory tract infections. Optic disc edema and amblyopia secondary to astigmatism are occasionally noted.

Adolescent↗

PubMed1976

X-linked ocular albinism. An oculocutaneous macromelanosomal disorder.

Three unrelated kindreds with the Nettleship-Falls type of X-linked ocular albinism were studied. Postmortem examination of the eyes of an affected man revealed the presence of macromelanosomes in the pigment epithelia. Skin biopsy specimens of this patient, seven other affected male, and nine carrier female kindred members revealed the presence of Fontana-positive and dopa oxidase-positive macromelanosomes within the epidermis and dermis. Although clinically this disorder has been considered to be a form of albinism confined to the eyes, these findings indicate that an unusual disturbance in melanosome production characterized by macromelanosome formation affects the skin and the eyes. Histopathologic study of the skin is a useful adjunct in the diagnosis of X-linked ocular albinism, both in the affected and the carrier states. Linkage studies confirmed the close association of the Xg blood group with this disorder.

Adult↗

PubMed1975

Invasive squamous cell carcinoma of the conjunctiva.

In cases of invasive conjunctival squamous cell carcinoma, three cases of deep corneal invasion and two cases of intraocular extension were found. Four cases showed orbital invasion, and one patient died of generalized metastases 18 months after diagnosis. The relatively low-grade nature of these lesions and their potential for local treatment is noted, but it is emphasized that careful clinical examination and close cooperation with the pathologist to ensure adequate evaluation of excised tissue are essential.

Adolescent↗

PubMed1975

Visual loss as the initial symptom in Hodgkin disease.

Involvement of the visual system in Hodgkin Disease generally occurs late in the course of the illness. A 43-year-old man was seen at the Johns Hopkins Hospital complaining of monocular visual loss. Clinical observations and neuroradiologic examinations suggested a chiasmal mass lesion, and the patient underwent a frontal craniotomy with biopsy of the chiasm. The biopsy specimen was diagnosed as a spongioblastoma of the optic chiasm, and the patient underwent a course of radiotherapy. Shortly after craniotomy, the patient developed evidence of a systemic illness and died eight months after onset of visual symptoms. Autopsy revealed extensive systemic involvement by Hodgkin sarcoma. Microscopical examination of the optic chiasm revealed no evidence of optic glioma but revealed diffuse infiltration by Hodgkin sarcoma. Reexamination of the original biopsy specimen confirmed that initial visual symptomatologic findings were secondary to intracranial Hodgkin disease.

Adult↗