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Biomedical subjects

W J MacLennan

Publications and source records attributed to W J MacLennan.

At least 19 recordsLinked to original sources

The accuracy of self and informant ratings of physical functional capacity in the elderly.

To compare the accuracy of self-ratings with informant-ratings of physical functional capacity in the elderly, 150 elderly patients attending a geriatric day hospital (GDH) and their formal and informal community carers were administered a questionnaire about their ability to perform activities of daily living (ADL). Direct observation of the patients' performance by therapists at the GDH was used as a standard, after the reliability and validity of this approach had been evaluated. Self-ratings were shown to be more accurate and less biased than informant-ratings, both for individual ADL and overall functional capacity. The accuracy of all ratings tended to be greater for less complex or physically demanding ADL, and informants tended to consistently underestimate functional capacity. The concurrent validity of the adapted Barthel Index in a self-report format was also demonstrated. Wherever possible, information concerning the physical functional capacity of an elderly subject should in the first instance be sought from the subject himself, as the quality of such information may be superior to that of his carers.

Activities of Daily Living

Prospective study of necropsy audit of geriatric inpatient deaths.

AIMS: To evaluate the accuracy of clinical diagnosis by specialists in geriatric medicine and to compare this with a previous study involving non-specialists. METHOD: Clinical and necropsy diagnoses from consecutive hospital inpatient deaths from the University Department of Geriatric Medicine were analysed for discrepancies at regular audit meetings. Three main categories of diagnosis were considered and any therapeutic implications discussed. RESULTS: Between 1987 and 1989 necropsies were performed on 100 patients (38 men, 62 women, aged 63 to 99 years) from a total of 207 deaths, a necropsy rate of 50%. There was complete agreement between necropsy and clinical diagnoses in 32% of cases. Disagreement involved the main diagnosis in 28%, contributory conditions in 32%, and cause of death in 34%. In 10% of cases the diagnostic discrepancy was considered therapeutically important. Specialist geriatricians correctly diagnosed the main diagnosis in 72% of cases; non-specialists in the previous study were correct in only 47% of cases. CONCLUSION: Specialist geriatricians diagnose elderly people more accurately than non-specialists. But rates of misdiagnosis are still significant and necropsies continue to be a useful form of audit.

Aged

The evaluation of dizziness in elderly patients.

Twenty-one elderly patients with dizziness underwent a comprehensive medical and otoneurological evaluation. The majority had vertigo, limited mobility and restricted neck movements. Poor visual acuity, postural hypotension and presbyacusis were also frequent findings. Electronystagmography revealed positional nystagmus in 12, disordered smooth pursuit in 18, and abnormal caloric responses in nine. Magnetic resonance imaging showed ischaemic changes in six out of eight patients. Although dizziness in the elderly is clearly multifactorial, the suggested importance of vertebrobasilar ischaemia warrants further consideration as vertigo has been shown to be a risk factor for stroke.

Aged

Clinical correlates of sway in elderly people living at home.

Postural sway has been noted to increase with advancing age and to correlate with a wide variety of clinical features. The relationships between sway and various clinical features were explored in a group of elderly subjects living at home and free from neurological illness and severe incapacity. Each subject underwent a thorough physical examination and sway was measured in the anteroposterior and lateral planes with eyes open and closed using a modified Wright's ataxiameter. Vibration sense was the only clinical feature to show a consistent relationship with all 4 measurements of sway in men. Age showed only a weak and inconsistent relationship to sway in both men and women. Weak but inconsistent relationships were noted between sway and mental function, tone, passive joint movement, antidepressant and tranquilliser therapy. This suggests that dorsal column function is of prime importance in the maintenance of balance and that the previously noted increase in postural sway with advancing age may have been exaggerated by the presence of disease processes.

Aged

Co-ordinating geriatric and general medical services; experience of a geriatric assessment ward in the Royal Infirmary of Edinburgh.

The paper describes the work of an assessment unit setup to provide a service for frail elderly patients admitted to general medical units at the Royal Infirmary of Edinburgh during the period of April 1989 to March 1990. Patients were selected on the basis of diagnosis, mental and physical function, age and social background and transferred to the assessment ward within 24 hours of admission to a medical ward. Most of the 376 patients admitted to the ward had a high level of multiple pathology and physical incapacity and a third had an acute confusional state. The mean length of stay was 19.4 days. There was a 13% mortality with 71% of survivors returning to their own homes. Review of mobility and self care capacity of the group revealed a striking increase in function during their stay in the ward. Factors increasing the likelihood of discharge included having a spouse, receiving support at home, having a low initial dependence rating. Adverse factors included having cerebrovascular disease, having dementia and initial maintenance of urine and faeces.

Activities of Daily Living

Evaluation of a comprehensive assessment battery for stroke patients.

The authors describe their experience of evaluating a battery of tests to assess function in patients with stroke and head injuries. They consisted of the Abbreviated Mental Test Score, Ravens Progressive Coloured Matrices, Hospital Anxiety and Depression Scale (HAD), Motricity Index, Shortened Rivermead Perceptual Assessment Battery (RPAB), Frenchay Aphasia Screening Test (FAST) and Barthel's Activities of Daily Living Index. These were applied to 50 patients, six of whom had had a head injury and 44 a stroke. Over 80% of subjects were able to complete the battery. Reasons for failure amongst the remainder were language problems, poor concentration and short term memory loss. Abnormalities in one aspect of cerebral function often compromised tests designed to assess another aspect of this. For example, upper limb incoordination interfered with RPAB, language difficulties affected the Abbreviated Mental Test, and HAD, and hemianopia compromised both RPAB and FAST tests. The battery can usually be completed within 1h, and could be performed by a wide range of professionals. It is likely to be particularly useful in screening for abnormalities requiring more detailed evaluation by particular professionals, and in monitoring the progress of patients during the course of treatment.

Activities of Daily Living

Stasis oedema in the elderly: are diuretics necessary?

Diuretic therapy was discontinued in 15 elderly patients. None of these patients had evidence of uncontrolled cardiac failure or hypertension, and they all had received diuretics long-term. Two patients required resumption of diuretics due to the development of cardiac failure or severe leg oedema. In the remaining 13 patients, mean leg volume increased by 8.2%. Discontinuation of diuretic therapy in elderly patients is associated with a small but significant worsening of lower limb oedema.

Aged

Plasma binding capacity for 25-hydroxy-vitamin D in the elderly.

Plasma 25-hydroxy-vitamin D (25-OHD) concentrations and 25-OHD binding capacities were measured in 14 elderly patients and in 14 young controls. Both 25-OHD concentrations and 25-OHD binding capacities were reduced in the elderly. In neither group, however, was there a significant correlation between 25-OHD binding capacities and 25-OHD concentrations. Thus, although 25-OHD binding capacities are reduced in sick old people this does not account for the low 25-OHD concentrations often found in this group.

Adult

Are potassium supplements for the elderly necessary?

Plasma and total-body potassium (TBK) were measured in 19 elderly patients receiving diuretics and potassium supplements for cardiac failure and in 13 elderly controls. The mean value for the ratio of TBK to fat-free mass (TBK:FFM) was significantly reduced in the patient group. TBK:FFM showed a negative correlation with age but no correlation with plasma potassium or dose of supplements. When controls and patients were matched for sex and age decade, the mean TBK:FFM was decreased significantly in the diuretic group, giving a mean potassium deficit of 13.3%. These results suggest that ageing influences potassium status, and that diuretics and cardiac failure have a greater effect on TBK in old age than in youth or middle age.

Age Factors

Ultra-violet irradiation and 25-hydroxy-vitamin D levels in sick old people.

Twelve elderly patients in a rehabilitation ward were given a four-week course of ultra-violet irradiation from a Vitalux lamp. They were compared with 12 controls selected from the same ward. Treatment produced a significant elevation in plasma 25-hydroxy-vitamin D (25OHD) by the end of the second week and concentrations continued to rise over the four-week period. Subject showing the greatest response were those starting with the lowest levels of plasma 25OHD. The findings suggest that ultra-violet irradiation is an effective means of treating vitamin D deficiency in old age and that patients with the greatest degree of deficiency show the greatest response.

Aged

25-hydroxy-vitamin D, diet and sunlight exposure in patients admitted to a geriatric unit.

Dietary intake, sunlight exposure and 25-hydroxy-vitamin D levels were estimated in 62 patients admitted to a geriatric assessment unit. There was a significant correlation between vitamin D intake and 25-hydroxy-vitamin D levels but none between sunlight exposure and these. This suggests that in old age dietary deficiency may be a more important cause of metabolic bone disease than limited sunlight exposure.

Adolescent

Adrenal function and ascorbic acid concentrations in elderly women.

Tetracosactrin (Synacthen) tests were performed on 19 elderly women who had leucocyte ascorbic acid (LAA) levels of less than 15 microgram/108 WBC. 9 were then given a daily dose of 200 mg ascorbic acid orally for 2 weeks while the other 10 were left untreated. Following this, tetracosactrin tests were repeated in both groups. All initial plasm cortisol responses to tetracosactrin were within normal limits. Treatment with ascorbic acid produced no changes in these. This suggests that the low LAA levels often found in old people do not result in adrenal insufficiency.

Adrenal Glands

Vitamin D supplements and 25-hydroxy vitamin D concentrations in the elderly.

Serial 25-hydroxy vitamin D (25-OHD) concentrations were measured in long-stay geriatric patients treated with vitamin D. Comparison between a treatment and a control group showed that a daily dose of 500 IU vitamin D produced a significant increase in 25-OHD levels by two months. The supplement had a striking effect when the initial 25-OHD level was low and very little effect when it was high. 25-OHD levels in subjects on 2000 IU vitamin D daily were only marginally higher than those in subjects on 500 IU. A dose of 500 IU vitamin D daily should therefore produce adequate blood 25-OHD concentrations in most old people, and probably prevent most cases of osteomalacia in the elderly--though a large-scale study is needed to confirm this.

Aged

The effect of acute illness on leucocyte and plasma ascorbic acid levels.

1. Serial estimations of plasma (PAA) and leucocyte (LAA) ascorbic acid concentrations were made in geriatric patients in a stable phase of their illness, and compared with a similar ('unstable') group suffering from acute illness. 2. In the 'unstable' group, though PAA levels were unchanged, LAA levels were reduced. 3. The 'follow-up' period of 7-8 d there was much greater variation in both PAA and LAA levels in the 'unstable' group. 4. Acute illness was often accompanied by an increase and then a decrease in LAA levels. Recovery was associated with an increase in LAA levels.

Acute Disease

The effect of potassium supplements on total-body-potassium levels in the elderly.

Weight, skinfold thickness, grip strength and the total-body-potassium content were measured in 13 healthy elderly subjects before and after a three-month course of potassium supplements given in a dose of 36 mmol per day. There were no significant changes in the total-body-potassium content or in the ratio of total body potassium to lean-body mass. An increase in the right-hand grip strength may well have been a placebo effect.

Aged

Protein intake and serum albumin levels in the elderly.

Protein intakes, energy intakes and serum albumin levels were measured in a long-stay geriatric unit. There was a significant positive correlation between albumin levels and protein intake in women, but not in men. A positive correlation was found between albumin levels and protein to calorie ratios in both men and women. This suggests that the protein intakes of long-stay geriatric patients may be suboptimal.

Age Factors