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Biomedical subjects

W J Noble

Publications and source records attributed to W J Noble.

3 recordsLinked to original sources

Chiropractic management of spondylolisthesis with spondylolysis of the pars interarticularis: an example of the single-case study experimental design.

Case records permeating the chiropractic literature, although claiming success utilizing conservative therapies, often are founded on isolated circumstances rather than scientific data. A detailed examination of such reports reveals a void with respect to definitive and specific approaches for the diagnosis and clinical management of disorders synonymous with chiropractic clinical practice. At best, therefore, such reports are fraught with empiricism, illustrating only the experiences of individual clinicians. The underlying difficulty encountered in reporting information on purely didactic grounds is likely due to the absence of a mechanism by which improvement in biomechanical function may be precisely and adequately quantified. In direct contrast, controlled clinical trials, as in medical research, offer the luxury of statistical clarity as to the selection of one treatment regimen over another. Researchers have indicated that the single-case study experimental design may be of value in chiropractic clinical practice, allowing for the formulation of deductive conclusions derived from each case. To facilitate the process, implementation of both retrospective and prospective aspects are proposed modifications to the general scheme. It is the purpose of this article to employ the concept of the single-case study experimental design, illustrating a condition commonly encountered in chiropractic clinical practice, that of spondylolisthesis. In so doing, we attempt to adhere to the prescribed format, while outlining both the retrospective and prospective aspects, commensurate with such a problem within the clinical setting.

Adult↗

Anterior interosseous nerve paralysis: cubital tunnel (Kiloh-Nevin) syndrome.

Paralysis of the anterior interosseous nerve may occur for a variety of reasons. It has been suggested that such a malady presents clinically more often than is recognized. Some authors attribute this to a general misunderstanding or ignorance of the precise anatomical distribution and motor function of this branch of the median nerve. The neuropathy produces a clinical scenario with a characteristic disturbance of the "pinch grip." Spontaneous recovery has been reported, but is said to be delayed and incomplete. Surgical exploration of the nerve may reveal a biomechanical basis for irritation, and decompression maneuvers may result in rapid and complete recovery. It is important to recognize, however, the value of conservative measures, including mobilization and adjustive procedures, which may be specifically directed to the elbow joint and other regions of the upper extremity. Such techniques may assist in reducing restrictive influences comprising the nerve and associated tissues. The benefits of electrotherapy may prove invaluable and, perhaps, should be considered prior to more radical procedures. Therefore, the practitioner should be wary of the potential to approach such a condition from the chiropractic perspective of treatment and management, which may yield rewarding sequellae.

Chiropractic↗

Atrial transport function in coronary artery disease: relation to left ventricular function.

The atrial contribution to ventricular stroke volume was evaluated in 50 patients with coronary artery disease and found to be related to left ventricular function. All patients underwent complete hemodynamic and angiographic studies. Angiographic volume studies were utilized to determine atrial contribution to the stroke volume, end-systolic volume and ejection fraction. In 11 patients without heart disease, atrial contribution to stroke volume was (mean value +/- standard deviation) 9.3 +/- 6 ml/m2 compared with 13.5 +/- 6 ml/m2 in the patients with coronary disease (probability [p] less than 0.05). The percent of atrial contribution to stroke volume was 20 +/- 7 and 33 +/- 11%, respectively, in normal subjects and patients with coronary disease (p less than 0.05). The combination of congestive heart failure and cardiomegaly was the only clinical aspect associated with a significantly higher (p less than 0.05) atrial contribution to stroke volume than that in the remaining patients with coronary disease (46 versus 31%). Relating the atrial contribution to stroke volume to the left ventricular end-diastolic pressure, stroke volume, end-systolic volume and ejection fraction revealed correlation coefficients of 0.30, -0.44, 0.56 and -0.64, respectively. No patient with a normal ejection fraction (greater than 0.50) had an atrial contribution greater than 40% of stroke volume. The ratio of peak left ventricular systolic pressure/end-systolic volume (mm Hg/ml) was 2.7 +/- 1.5 in patients (n = 14) with an atrial contribution greater than 40% of stroke volume compared with 5.3 +/- 3.4 in patients having an atrial contribution of 40% or less (p less than 0.01). These findings indicate that atrial contribution to stroke volume is inversely related to left ventricular function.

Adult↗