Influence of ventricular activation on ventricular compliance.
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Animals↗
Biomedical subjects
W J Powell
Publications and source records attributed to W J Powell.
Laryngeal sarcoidosis with airway obstruction.
Sarcoidosis is a chronic systemic granulomatous disease that occasionally affects the larynx. When the degree of involvement is marked, significant airway obstruction can occur. We present four cases of laryngeal sarcoidosis that resulted in airway obstruction. The clinical features of sarcoidosis of the larynx are discussed, and current methods of treatment are summarized. The laryngologist should include laryngeal sarcoidosis in the differential diagnosis of patients with airway obstruction, and should play a major role in its management.
Adult↗
The role of the liver in the adrenergic regulation of blood flow from the splanchnic to the central circulation.
Cardiac output is determined, in large part, by the venous return of blood to the heart. Various adrenergic and pharmacologic influences affect venous return. In the dog it appears that the liver may play an important role in the control of blood flow from the splanchnic to the central circulation and, hence, in the control of venous return.
Animals↗
Cytotoxicity of ribo-and arabinoside boron nucleosides in tissue culture cells.
Ribose and arabinoside boron nucleoside derivatives were shown to be potent cytotoxic agents in murine and human suspended and solid tumor cell lines. The arabinoside derivative inhibited DNA and RNA synthesis with the protein synthesis requiring a higher concentration of drug for inhibition within 60 min. The purine pathway appeared to be the major target of the arabinoside 1 with inhibition of PRPP amido transferase and IMP dehydrogenase activities. Blockage of this pathway afforded reductions of deoxyadenosine and deoxyguanosine nucleotide pools. The DNA template did not appear to be target of the arabinoside 1, in that there was no change in DNA viscosity, thermal denaturation or absorption of nucleosides of DNA. However, compound 1 when incubated with L-1210 cells for 24 hr. showed a slight shift of the DNA in the gradient and moderate inhibition of ct-DNA topoisomerase II was demonstrated by 1 in vitro.
Animals↗
Substituted carboranes and polyhedral hydroborate salts as anti-neoplastics.
Substituted carboranes and polyhedral hydroborate salts were observed to be potent anti-neoplastic/cytotoxic agents inhibiting the growth of mouse and human leukemias, human uterine, colon adenocarcinoma, lung bronchogenic and gliomas. Amino-o-carborane-hydrochloride 7, one of the more potent compounds, preferentially inhibited Tmolt3 DNA synthesis. The target of the agent appears to be de novo purine synthesis with significant inhibition of the activities of both regulatory enzymes, PRPP-amido transferase and inosine monophosphate dehydrogenase as well as dihydrofolate reductase. The agent also inhibited nucleoside kinase activities leading to reductions in deoxyribonucleotide pools. The DNA molecule itself was not a target of the agent.
Adenocarcinoma↗