Clear cell variant of mucoepidermoid carcinoma of the skin.
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Adult↗
Biomedical subjects
W J Reitmeyer
Publications and source records attributed to W J Reitmeyer.
Cutaneous vascular calcification with ulceration in hyperparathyroidism.
We report a histologically distinctive form of small blood vessel calcification that led to necrosis and ulceration of the skin. Microscopically, wedge-shaped ulcers of the skin and superficial subcutis were observed. Calcified deposits were identified in the walls of small blood vessels at the ulcer bases. Recanalized thrombi occluded the lumina of some of the calcified vessels. On the basis of these distinctive histologic findings, hyperparathyroidism was accurately predicted. These changes have previously been cited in the internal medicine and dermatology literature but, to our knowledge, not in the pathology literature. We believe that these lesions are not rare and are probably often overlooked by pathologists. The histologic and clinical findings in two cases are presented.
Adult↗
Marked digoxin-like immunoreactive factor interference with an enzyme immunoassay.
A case in which digoxin-like immunoreactive factors (DLIF) interfered with an enzyme immunoassay in a patient with renal insufficiency is reported. A 79-year-old woman was found to have a serum digoxin concentration (SDC) determined by enzyme immunoassay of 5.0 ng/ml. Although all subsequent SDC determined by the enzyme immunoassay system were elevated, identical samples run on a fluorescence polarization immunoassay revealed SDC within the therapeutic range. Marked DLIF-related assay interference has been reported to occur with some digoxin assays; however, the enzyme immunoassay methods have never been reported to cross-react to the magnitude seen in this case.
Aged↗
Oncocytic pleomorphic adenoma of the parotid gland.
A rare case of salivary gland pleomorphic adenoma, in which the majority of cells were oncocytic, is reported. The patient, a 53-year-old man, presented with a parotid gland mass that was otherwise asymptomatic. Surgical treatment consisted of a superficial parotid lobectomy. The specimen was prepared in standard fashion and studied by light and electron microscopy. The microscopic features were characteristic of salivary gland pleomorphic adenomas, however, both epithelial and "mesenchymal" elements were oncocytic. Such changes may occur focally in pleomorphic adenomas, but we were unable to find documentation of a wholly oncocytic variant in a review of the medical literature. From our clinical data and previous reports of pleomorphic adenomas with focal oncocytosis, it is concluded that such changes likely do not alter prognosis in affected patients. The possible significance of this lesion in regard to the histogenesis of salivary gland pleomorphic adenomas is discussed.
Adenoma, Pleomorphic↗