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Biomedical subjects

W J Tuddenham

Publications and source records attributed to W J Tuddenham.

At least 19 recordsLinked to original sources
PubMed1989

Enterococci highly resistant to penicillin and ampicillin: an emerging clinical problem?

Sixteen clinical isolates of ampicillin-resistant enterococci (ARE) were recovered from the microbiology laboratory of a 450-bed rehabilitation medical center from January 1981 to September 1987. These isolates were detected when a disk diffusion test using 10 micrograms of ampicillin on a blood agar plate revealed no zones of inhibition. Tube macrodilution tests yielded an MIC of greater than or equal to 16 micrograms of ampicillin per ml. None of the isolates were penicillinase producers by the chromogenic cephalosporin disk test. Ten isolates were Enterococcus faecium, four isolates were E. raffinosus, one isolate was E. gallinarum, and one isolate was not identified (lost). There were 6 male and 10 female patients. The sources of isolates were urine (n = 7), wound (n = 5), ascitic fluid (n = 2), blood (n = 2), peritoneal catheter tip (n = 1), Bartholin's cyst abscess (n = 1), rectal swab (n = 2), and pancreatic abscess (n = 1). The organism was isolated from multiple sites in 4 patients, was a pure culture isolate in 5 patients, and was part of a polymicrobial flora in 11 patients. Six patients were diabetic, and four had liver cirrhosis. All but four patients had received at least one antibiotic within 3 weeks of ARE isolation. The MICs (micrograms per milliliter) for 50 and 90% of isolates tested, respectively, were as follows: ampicillin, 64 and 64; penicillin, 128 and greater than 128; vancomycin, 1 and 2; gentamicin, 4 and 16; ciprofloxacin, 1.6 and 3.2; imipenem, 128 and greater than 128; and daptomycin (LY146032), 1.6 and 6.4. ARE may be an emerging pathogen in the hospitalized patient population.

Adolescent↗
PubMed1982

Primary lymphoma of the spinal cord.

Lymphomas may occur in the central nervous system either as primary lesions or secondary to lymphomas in other sites. While lymphomas secondary to generalized lymphoproliferation may occur in either the brain or the spinal cord, primary lymphomas are found almost exclusively in the brain. Only three primary lymphomas of the cord have been reported. We recently had the opportunity to study a fourth case. Spinal cord lymphoma was not the diagnosis considered in any of these cases. Since the lesion is radiosensitive, inclusion of primary lymphoma in the differential diagnosis of obscure spinal cord tumors could result in a histological diagnosis and effective therapy.

Diagnosis, Differential↗
PubMed1982

Failure of rifampin to eradicate methicillin-resistant Staphylococcus aureus colonization.

Four patients with methicillin-resistant Staphylococcus aureus (MRSA) carriage in one body site each (urine, anterior nares, throat, or wound) received 300 mg of oral rifampin twice daily for ten days. Treatment did not eradicate MRSA carriage in any patient, and three of the posttherapy isolates were highly resistant to the drug. Rifampin by itself does not appear to be an effective drug for the eradication of MRSA carriage.

Adult↗
PubMed1980

Pseudomonas urinary tract infection in mice.

When Pseudomonas aeruginosa was injected through a catheter into the bladder. Hemorrhage, edema, and vessel engorgement were seen 1 h after challenge. At 3 hours we observed microulceration of the bladder, which rapidly healed and was rarely present after 24 h. Pseudomonas was cultured from 50% of the kidneys at 1 week, and the number of kidneys infected decreased over 4 weeks.

Animals↗
PubMed1979

Quality Assurance in diagnostic radiology: an irreverent view of a sacred cow: annual oration in honor of Albert Soiland, M.D.

The problem of federal regulation of radiologic practice is examined via an in-depth analysis of the Proposed Recommendations for Diagnostic Radiology Facility Quality Assurance Programs as published in the Federal Register by the Commissioner of Food and Drugs. It is shown that the need for such recommendations is not established, that the program proposed by the Commissioner is potentially burdensome for the radiologist, that it does not address the most significant causes of unnecessary patient irradiation, and that the benefits expected to derive from it are, in fact, negligible. This is not to denigrate the value of well-conceived quality assurance efforts, and measures are suggested that might more reasonably be expected to reduce the radiation exposure of the public. The radiologist is urged to 1) conduct his practice in as faultless a manner as possible; and 2) exercise his right to respond to proposals of the federal regulatory agencies.

Cost-Benefit Analysis↗