Biomedical subjects

W J van der Bijl

Publications and source records attributed to W J van der Bijl.

7 recordsLinked to original sources

PubMed1980

A double-blind comparison of oxatomide (R 35 443) and diphenhydramine in the treatment of hay fever.

Ninety-one hay fever patients received either 0.5 mg/kg oxatomide b.i.d. or 0.4 mg/kg diphenhydramine b.i.d. in a two-month double-blind study. If necessary this dose could be doubled. The results showed that fewer oxatomide patients needed to double this starting dose and to use a nasal spray. Oxatomide proved to be more effective than diphenhydramine in limiting the severity of the hay fever attacks, as evidenced by the findings that oxatomide patients had fewer complaint-days, and that more of these patients were rated by the investigators to have excellent or good results. Apart from daytime fatigue, transient in several patients, no oxatomide-induced side-effects were found.

Adolescent↗

PubMed1977

Report on a trial of SCG 2% nasal solution (metered dose) in hayfever.

An analysis has been performed on the results from 18 patients treated with SCG and 14 patients treated with placebo in a double-blind placebo-controlled group comparative trial of SCG 2% nasal solution (metered dose) in hayfever. The two treatment groups were found to be similar with respect to relevant characteristics and pre-trial symptomatology. Analysis of clinician's symptom scorings demonstrated statistically significant differences in favour of SCG for the symptoms Sneezing, Running and Itching. No significant differences between the treatments were found in the statistical analysis of patient diary card total scores. Five assessments of overall response made at the end of treatment gave results highly significantly in favour of SCG.

Administration, Intranasal↗

PubMed1971