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Biomedical subjects

W Jawień

Publications and source records attributed to W Jawień.

5 recordsLinked to original sources

[Use of different drug form identification systems].

Since the foundation of the Department of Clinical Toxicology one of the unsolved problems is the identification of drugs which are often brought by the emergency service together with the patient. This problem is known to the personnel of Poison Centers and all first-contact physicians who deal with the patient at home or at the place of accident. Many years of observations and experiences allowed for creating Polish system of drugs identification based mainly on the catalogue containing data to be used in identification of an unknown form of a drug. The next step was to create a computer database system allowing for fast and accurate identification of drug forms. Created catalogue contains drug forms categorized by color and shape. The solution is constructed in a way that adding new and extending existing data is possible. The catalogue can be used in drug stores, by emergency services, family doctors and specifically in pediatrics since children are often exposed to the danger of unknown drug intake. The useful option is the color printout which can be obtained from the system. Search procedures enable setting range of criteria and, after initial list is produced, detailed search is possible with the color images on screen. The system was created using MS Access database. Department of Toxicology is the owner of the copyrights.

Databases, Factual↗

Variability of the model-independent AUC: the one sample per individual case.

A theory is developed for estimation of a population value of AUC along with its standard deviation, in the case, when only one concentration-time (C-t) sample is available for each individual. This theory is based on model-independent pharmacokinetics. Integration methods are classified due to their applicability to the presented approach. The main goal of this work is to establish a statistical hypothesis-testing procedure which would make single C-t samples usable for bioequivalence studies. An application of the theory to a number of integration methods currently in use is analyzed in detail. A real data illustration is included.

Area Under Curve↗

On continuity of integration methods for AUC. A note.

A lack of monotonicity and discontinuity of some integration methods for AUC, as a function of measured concentration, is demonstrated. Hybrid methods consisting of either parabolas-through-the-origin or the alpha-function method followed by the log-trapezoidal method were found to be discontinuous at the switching point. The stable piecewise third-order polynomial method appeared to be nonmonotonic as well as discontinuous.

Algorithms↗