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Biomedical subjects

W Jenkins

Publications and source records attributed to W Jenkins.

12 recordsLinked to original sources
PubMed1996

The relationship between static posture and ACL injury in female athletes.

Female participation in athletics has increased dramatically over the last decade. Accompanying the increase in participation in sports is the increase incidence of anterior cruciate ligament (ACL) injury. The purpose of this study was to examine the correlation between static postural faults in female athletes and the prevalence of noncontact ACL injury. Twenty ACL-injured females and 20 age-matched controls were evaluated. Seven variables were measured: standing pelvic position, hip position, standing sagittal knee position, standing frontal knee position, hamstring length, prone subtalar joint position, and navicular drop test. A conditional step-wise logistic regression analysis revealed the factors of knee recurvatum, an excessive navicular drop, and excessive subtalar joint pronation to be significant discriminators between the ACL-injured and noninjured groups. These findings may have implications regarding rehabilitation techniques in physical therapy.

Adolescent↗
PubMed1995

Epidemiology of minority health.

Collecting epidemiologic data by ethnicity and race is a highly useful undertaking; but "bench mark" comparisons relative to majority Americans should not take priority over defining the determinants of health status within a minority group. Thus, it is necessary to identify factors contributing to the measured health status and to modify the environment, lifestyles, and behaviors to diminish the likelihood of undesirable health outcomes. This article presents an overview of the health status of African Americans, Asians and Pacific Islanders, and Hispanics. The goals are to provide a framework for the rational interpretation of both health status data and its determinants both within and between minority groups. This approach recognizes the heterogeneity of health status that exists within a minority group and encourages investigators to place more emphasis on the within-group health status differentials as they search for modifiable factors that underlie the risk for undesirable health outcomes.

Adolescent↗
PubMed1981

Hepatic organelle pathology in primary biliary cirrhosis and the response to low-dose D-penicillamine therapy.

1. Analytical subcellular fractionation in combination with enzymic microanalysis has been used to investigate the hepatic organelle pathology of primary biliary cirrhosis. Activities of plasma membrane and lysosomal enzymes in hepatic needle biopsies were increased, but marker enzymes for other organelles were normal. 2. Seven patients were treated with a low dose of penicillamine, 250 mg daily, over a 3--6 month period. The initially raised serum alkaline phosphatase and IgM levels were significantly reduced. In four patients with markedly elevated hepatic copper there was a small decrease, but urinary copper excretion was unaltered. Hepatic organelle pathology was significantly improved. 3. No serious side-effects were noted and it is suggested that a controlled trial of low-dose D-penicillamine therapy is indicated in patients with primary biliary cirrhosis.

Adult↗
PubMed1980

Subcellular fractionation studies on hepatic tissue from a patient with Pompe's disease (type II glycogen-storage disease).

1. An homogenate of liver biopsy taken from a patient with Pompe's disease (type II glycogen-storage disease) was analysed by enzyme microassay and subcellular fractionation by sucrose-density-gradient centrifugation. 2. A strikingly low activity of lysosomal acid alpha-D-glucosidase was noted but there was also increased activity of neutral alpha-D-glucosidase (found in endoplasmic reticulum). 3. Activities of the acid hydrolases, acid phosphatase and beta-N-acetyl-D-glucosaminidase, were elevated compared with those of controls. Measurement of latent beta-N-acetyl-D-glucosaminidase activity and results of subcellular fractionation experiments, indicated a marked fragility of certain populations of lysosomes. Lysosomes containing predominantly acid phosphatase and beta-D-glucuronidase activities appeared to have normal integrity. 4. Assessment of organelle pathology by enzyme microassay indicated low mitochondrial and peroxisomal enzyme activities. In addition there was evidence of mitochondrial damage as reflected by increased sucrose permeability and by ultrastructural studies.

Acetylglucosaminidase↗
PubMedDate not supplied

Chronic active hepatitis in a patient presenting with clinical and serological evidence of SLE.

A patient with clinical and serological manifestations of systemic lupus erythematosus (SLE) without renal or neurological manifestations was managed conservatively for 4 1/2 years. At this time she developed ascites and abnormal liver function tests, and was found to have severe chronic active hepatitis (CAH) with cirrhosis and portal hypertension. No clinical or biochemical evidence of liver disease was documented over the first 3 1/2 years of her illness, though no tests were performed in the 12 months before diagnosis. This case emphasizes the value of monitoring liver function tests over extended periods in such patients, since appropriate immunosuppressive therapy may benefit CAH, and as in this case, systemic manifestations of CAH may simulate SLE and precede clinical liver disease.

Adult↗