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Biomedical subjects

W K Bottomley

Publications and source records attributed to W K Bottomley.

At least 19 recordsLinked to original sources
PubMed1993

A retrospective evaluation of 193 patients with oral lichen planus.

One hundred and ninety-three patients with oral lichen planus were evaluated retrospectively. Women outnumbered men by more than two to one. The mean age at lesion discovery was in the sixth decade. The buccal mucosa was the most common site of occurrence. There were concomitant systemic diseases in many of the patients. The ulcerative form was the most prevalent referred form. Therapies included observation and treatment with topical and systemic corticosteroids with and without anti-fungals and immunosuppressants. Areas of discussion include lesion location, chronicity, therapeutic modalities, malignant transformation, age, gender, symptomatology and systemic disease.

Adult↗
PubMed1991

The administration of folic acid to institutionalized epileptic adults with phenytoin-induced gingival hyperplasia. A double-blind, randomized, placebo-controlled, parallel study.

Twenty severely retarded institutionalized epileptic adults with phenytoin-induced gingival hyperplasia were divided into two groups and received a daily 3 mg capsule of either folic acid or lactose for 16 weeks in a randomized, double-blind, parallel study. Serum folate and phenytoin levels were recorded at baseline and on completion of the study. Twelve areas of the gingiva on each patient were graded at 4-week intervals for 16 weeks with respect to the three indexes: hyperplasia, gingival health, and plaque index. There were no significant differences between treatment groups for any of the three indexes over time. The poststudy serum folate levels were three times baseline levels for the active drug group (p less than 0.001) but unchanged in the placebo group. Phenytoin blood levels that began within the therapeutic window (10 to 20 micrograms/ml) tended to remain within the therapeutic window for both groups, with no reported seizure activity. A single daily oral 3 mg capsule of folic acid did not show efficacy as the sole therapeutic agent in the reduction of phenytoin-induced gingival hyperplasia.

Adult↗
PubMed1991

On the mechanism of drug-induced gingival hyperplasia.

Proposed mechanisms of the side effect of drug-induced gingival hyperplasia are reviewed. Hypotheses with regard to inflammation from bacterial plaque, increased sulfated glycosaminoglycans, immunoglobulins, gingival fibroblast phenotype population differences, epithelial growth factor, pharmacokinetics and tissuebinding, collagenase activation, disruption of fibroblast cellular sodium/calcium flux, folic acid and a combination hypothesis are evaluated.

Dental Plaque↗
PubMed1990

Nitrendipine-induced gingival hyperplasia. First case report.

Drug-induced gingival hyperplasia is well documented within the literature. It has been associated with phenytoin, cyclosporine, and calcium channel blocking agents. Nitrendipine is an experimental calcium channel blocking agent that also appears to cause the side effect of drug-induced gingival hyperplasia. The clinical and histologic presentation of this side effect and possible biochemical mechanisms of pathogenesis are discussed.

Aged↗
PubMed1990

A retrospective oral/dental evaluation of 92 head and neck oncology patients, before, during and after irradiation therapy.

Ninety-two head and neck radiation/oncology patients were referred for a pre-irradiation dental examination. Of these patients, 48 required at least one extraction, and 51 required at least one restoration. Only 19 patients did not require extractions, restorations or endodontic therapy. All but one patient required a dental prophylaxis. The oral complications of head and neck irradiation therapy were evaluated and discussed. The importance of adjuvant oral/dental care for the head and neck radiation/oncology patient is addressed. The distribution of patients requiring treatment (extractions, restorations and/or endodontic therapy) versus no treatment (a dental prophylaxis only) showed that a significantly higher number of patients (chi-square = 37.5; p less than 0.01) required treatment over no treatment.

Adolescent↗
PubMed1987

Histiocytosis X: report of an oral soft tissue lesion without bony involvement.

The case of a 65-year-old white man with painful oral soft tissue granulomatous lesions of histiocytosis X is reported. The clinical course and diagnostic and therapeutic measures are described. The manifestation of symptomatic oral soft lesions with no definable lesions of bone and the age of the patient are not consistent with the usual presentation of this disease, and thus emphasize its clinical variability. The rationale for the therapeutic regimen and the prognosis are reviewed.

Aged↗
PubMed1986

Radiographic and clinical laboratory procedures.

Diseases of the oral cavity and related structures, either local or systemic, may have profound physical and emotional effects on a patient. In order to effectively manage these conditions, it is necessary that dentists have a basic understanding of diseases throughout the body. Such an obligation is tempered only by the extent to which diseases relate to the dental profession's anatomic field of responsibility or have clinical implications for office personnel, and the extent to which diseases require modification of dental therapy or alter the prognosis. A primary organic abnormality is typically reflected in the findings of radiographic, laboratory, and tissue studies. From the analysis of a large number of such profiles, certain patterns emerge that are sufficiently characteristic to suggest a specific diagnosis or groups of differential diagnoses for abnormalities that may prompt a request for urgent dental care.

Biopsy↗