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W K Fung

Publications and source records attributed to W K Fung.

4 recordsLinked to original sources
PubMed1997

Comparison of Hae-III-generated VNTR profiles of Chinese in Hong Kong and Singapore.

Some statistical analysis and experiments have been carried out on the single-locus VNTR reference databases collected separately from the Chinese in Hong Kong and Singapore to assess the issues of sample size and representativeness in the context of forensic science. We employed the bootstrap method and the Pearson chi-squared test for independence, and found that the different reference databases have very little effect in assessing the frequencies of occurrence of variable number of tandem repeats (VNTR) profiles. The results of random match probability assessment also indicate that the sample sizes studied appeared adequate to provide representative data. It has been found that a battery of four loci was enough to distinguish the 458 individuals under study.

Asian People↗
PubMed1997

Testing linkage equilibrium on allelic data between VNTR loci.

We extend Geisser and Johnson's methods and propose simple tests for linkage equilibrium of fragment lengths between VNTR loci. The tests are shown to have asymptomatically normal or chi-square null distributions. They are applied to the reference databases of Asian populations, including the Hong Kong Chinese, Singapore Chinese, Singapore Malays, and Singapore Indians. It seems that there is little linkage disequilibrium in the data.

Alleles↗
PubMed1996

Are convenience DNA samples significantly different?

In this paper, the issue of whether DNA databases collected by different convenience sampling methods are significantly different statistically is investigated. Testing the null hypothesis that the population probability or frequency distributions of DNA profiles under different sampling methods are the same is of interest in this investigation. Some statistical analyses are conducted on the single-locus VNTR databases collected from different sources by the Hong Kong Government Laboratory. The bootstrap, Monte Carlo simulation and significance tests including the Pearson's chi-squared, likelihood ratio, and Kolmogorov-Smirnov two-sample statistics are employed for testing the hypothesis. The results are promising that no probability values of the tests are smaller than 5%. In other words, there is not enough evidence to reject the null hypothesis at the 5% level, which provides more confidence for using the VNTR reference databases commonly collected by convenience sampling.

DNA↗