Biomedical subjects
Publications and source records attributed to W K Hill.
Variations in the dose-response curve were graphically and arithmetically represented for the serum agglutination test in brucellosis, instances being given of the use in field conditions of a method of standardizing antigens and testing reference sera compared with standard preparations.
Report on the results of serological studies on the species Leptospira interrogans in cattle (19,607), swine (6,348), dogs (182) and horses (88) from the Netherlands during the period from 1969 to 1974. Living cultures of the serotypes of pomona, icterohaemorrhagiae, canicola, guidae (Tarassovi serological group), grippotyphosa and sejroe were used as antigen in the micro-agglutination test. The numerical findings showed that antibodies to serotypes of the species Leptospira interrogans were present in 7.67 per cent of the cattle, 22.21 per cent of the pigs, 36.81 per cent of the dogs and 92.05 per cent of the horses studied. Infection with the serotypes of icterohaemorrhagiae and grippotyphosa was most common in cattle and horses, icterohaemorrhagiae and tarassovi were most common in swine and icterohaemorrhagiae and canicola were most common in dogs. The presence of pomona is not a factor in the Netherlands. In view of statistical findings, grippotyphosa infections in cattle may be assumed to result in abortion.
The preparation of a number of E. coli vaccines designed to prevent enterotoxicosis due to E. coli in young piglets is discussed. The results of laboratory experiments concerned with the production of haemagglutinating antibodies in pigs following inoculation of this vaccine are reported. This oil-adjuvant vaccine (OAV) was used in the field in thirty-one herds in which enterotoxicosis due to E. coli was a recurrent problem. It is concluded from serological and clinical observations that the use of this vaccine is advisable on farms on which enterotoxicosis due to E. coli occurs in young piglets.
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