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Biomedical subjects

W K Yeates

Publications and source records attributed to W K Yeates.

At least 19 recordsLinked to original sources

Ejaculation and its disorders.

Ejaculation is the final link of the male sexual function chain "Libido--Erection--Penetration--Achievement of Climax--Ejaculation". Each link is highly androgen-dependent. Although the initiation of a subsequent link is normally dependent on achievement of the previous link, each link has its own mechanisms, and can be made to occur in isolation. The basic requirements for ejaculation are the production of seminal fluid (mostly from the seminal vesicles) and its propulsion. The production of a normal volume of seminal fluid requires the presence of seminal vesicles and the maintenance of their secretion by androgens. The propulsion of seminal fluid is in 3 phases: I. Contraction of seminal vesicles; II. Closure of bladder neck (both due to T9-L2 sympathetic stimulation); III. Expulsion of semen from the bulb of the urethra (due to S2-S3 somatic stimulation). The coordination of these phases is probably at hypothalamic level. Failure of ejaculation may be classified into I. Deficiency of production of seminal fluid from (1) Absence of seminal vesicles or (2) Androgen deficiency from (a) Pituitary dysfunction or (b) Testicular interstitial-cell failure from a number of causes. Correction of androgen deficiency usually restores ejaculation.

Ejaculation↗

Pain in the scrotum.

The symptom of pain in the scrotum is one that can occupy a large amount of a doctor's time and compromise his credibility with the patient. This need not be if he understands the physiology of pain production in the scrotum, and follows simple management guidelines.

Autonomic Nervous System↗

Respiratory tract disease and obstructive azoospermia.

Male infertility may be linked to respiratory tract disease in conditions such as cystic fibrosis and Kartagener's syndrome. Young's syndrome constitutes another such link, in which bronchiectasis is found in association with obstructive azoospermia and normal testicular function. We have studied 34 infertile men with mechanical azoospermia and appropriate control subjects to assess the number of patients with respiratory tract disease and the type and frequency of such disorders. Nineteen patients (59%) had grossly abnormal sinus radiographs compared with six controls (18%) (p less than 0.01) and 19 (56%--NS) gave a history of sinusitis; of these, six (18%) had had sinus operations (p less than 0.01). Eleven patients (32%) had histories of repeated otitis media, of whom two had had mastoid operations. Twelve (35%) had chronic bronchitis, of whom three were non-smokers. Ten other patients had bronchiectasis (p less than 0.001) and three of these had had a lobectomy. The chest radiograph was abnormal in 18 patients (p less than 0.001), including all 10 with bronchiectasis. Two patients had severe airflow obstruction and 13 others had a mildly obstructive pattern. This controlled study confirms that a significant excess of sinorespiratory disease can be identified in young men with obstructive azoospermia. We have found no features in the history or in the results of examination or investigations to explain why some of these patients have respiratory tract disease while others do not.

Adult↗

British urology 1982.

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Education, Medical, Graduate↗

The clinical value of bladder capacity measurement at physiological pressure under anaesthesia.

Bladder capacity, when measured at physiological pressure under light anaesthesia, is a simple useful procedure of considerable practical value, in that it allows valid comparison with the functional capacity during consciousness. Similar volumes indicate structural changes in the bladder wall, whereas different volumes indicate the neurological element in the mechanism of the frequency.

Anesthesia, General↗

Mr J. D. Fergusson.

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History, 20th Century↗

Indications for bladder transection.

Over the last 8 years 64 cases of bladder hyperactivity have been subjected to bladder transection. The patients seleced have been mainly adult enuretics, but have also included some others with daytime bladder hyperactivity without nocturnal incontinence who had failed to respond to medical and simple surgical procedures. A bladder capacity greater than 400 ml under general anaesthesia was used as a major criterion in selecting the cases for operation. The operation was very successful in the enuretic syndrome where the daytime symptoms or urgency and urge incontinence were severe. Other patients who had frequency, urgency and urge incontinence without demonstrable neurological or urological abnormalities also responded well.

Adolescent↗

Male infertility.

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Cell Count↗

Bladder transection for adult enuresis.

45 patients with adult enuresis have been treated by bladder transection between 1969 and 1975 and followed-up from 6 months to 7 years. 24 patients are now asymptomatic. Bladder transection gave very worthwhile results in 53% of cases.

Adolescent↗