[On the age-dependent activity of the plasms thromboplastin antecedent (PTA, factor XI)].
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Biomedical subjects
Publications and source records attributed to W Künzer.
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Between 1970 and 1980 there were 43 patients (28 boys, 15 girls) treated for an orbital cellulitis at the Freiburg University Children's Hospital. The most frequent underlying condition is maxillary or ethmoidal sinusitis. The most frequent causative agents are pneumococci and staphylococci. Vigorous antibiotic treatment with ampicillin, oxacillin, and - if necessary - with chloramphenicol is absolutely considered to be the therapy of choice as compared to any surgical procedure; this holds also true of the more advanced stages of orbital involvement, provided the cellulitis is primarily due to infection and not primarily due to a traumatic lesion of the orbital area.
5 patients 10 to 20 months old with severe normochromic, normocytic anemia and reticulocytopenia are reported. All patients recovered within 10 days to 5 weeks. No steroid therapy was given. Failure to recognize the clinical entity leads to unnecessary diagnostic and therapeutic procedures including the transfusion of blood.
A case of a newborn with osteomyelitis of the spinous processes 10 and 11 is presented. The first clinical sign was a dorsothoracal abscess. Radiologically a destruction of the 10th, later also the 11th spinous process could be demonstrated. Staphylococcus aureus was isolated. The clinical course was mild. The pathogenesis of the disease is discussed. Such a case of newborn osteomyelitis has apparently not been described in the literature.
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