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Biomedical subjects

W Kalbfleisch

Publications and source records attributed to W Kalbfleisch.

4 recordsLinked to original sources

[Morphologic findings in the placenta in intrauterine fetal growth retardation].

The placentas of 105 small-for-dates infants and 190 newborns of normal birth weight were investigated morphologically. Each of these two groups consists of premature newborns and mature newborns. Macroscopic and microscopic data were evaluated by means of a so called data bank. --The weight and the area of attachment were determined. The histologic findings were classified in two groups: 1. Disturbances of placental maturation, 2. Morphologic changes in consequence of reduced uteroplacental blood flow. A marked increase of hypoplastic placentas was found among immature and mature small-for-dates infants. Retarded placental maturity was found more frequently among mature small-for-dates infants then among prematures. Among these, placentas with signs of a reduced uteroplacental perfusion were found more frequently. --It is assumed that the pathogenetic course is different in placentas of premature and mature small-for-dates infants.

Female↗

CBF--computer handling of chemical and biological facts.

CBF is an EDP-supported documentation and retrieval system for structural formulas of defined organic compounds and their biological activities. It fits the needs of a firm concerned with drug research for prevailing unpublished internal data, which the scientists can use for reflections on structure-activity relationships and to search for lead compounds with specific activity profiles.

Biology↗

A new easily accessible steric parameter for structure-activity relationships.

A simple steric parameter Sb is formulated on the basis of substituent branching. This parameter can be calculated for every conceivable substituent and gives an estimate of steric effects which is sufficient for most purposes in practical drug design. Sb may also be applied to quantitative structure-activity relationships.

Models, Chemical↗